Interdigital Resonators in Wideband Ridged-Waveguide Filters

An interdigital resonator approach for wideband filter applications in ridged-waveguide technology is presented. The interdigital arrangement of the ridged-waveguide resonators ensures stronger coupling between the resonators. As the coupling sections are consequently enlarged by the interdigital arrangement of the resonators, more feasible filter structures are possible at increasing frequencies. The approach itself can be easily implemented with conventional filter synthesis formulas, which is demonstrated by two 20 GHz examples with a bandwidth of 2 GHz and 100 MHz, respectively. The designed filters are subsequently compared to the standard implementation of ridged-waveguide filters.</p

In vitro Efficacy of a Novel Guanosine-Analog Phosphonate

Actinic keratosis, a frequent carcinoma in situ of non-melanoma skin cancer (NMSC), can transform into life-threatening cutaneous squamous cell carcinoma. Current treatment is limited due to low complete clearance rates and asks for novel therapeutic concepts; the novel purine nucleotide analogue OxBu may be an option. In order to enhance skin penetration, solid lipid nanoparticles (SLN, 136-156 nm) were produced with an OxBu entrapment efficiency of 96.5 ± 0.1%. For improved preclinical evaluation, we combined tissue engineering with clinically used keratin-18 quantification. Three doses of 10-3 mol/l OxBu, dissolved in phosphate-buffered saline as well as loaded to SLN, were effective on reconstructed NMSC. Tumour response and apoptosis induction were evaluated by an increase in caspase-cleaved fragment of keratin-18, caspase-7 activation as well as by reduced expression of matrix metallopeptidase-2 and Ki-67. OxBu efficacy was superior to equimolar 5-fluorouracil solution, and thus the drug should be subjected to the next step in preclinical evaluation

On noise treatment in radio measurements of cosmic ray air showers

Precise measurements of the radio emission by cosmic ray air showers require an adequate treatment of noise. Unlike to usual experiments in particle physics, where noise always adds to the signal, radio noise can in principle decrease or increase the signal if it interferes by chance destructively or constructively. Consequently, noise cannot simply be subtracted from the signal, and its influence on amplitude and time measurement of radio pulses must be studied with care. First, noise has to be determined consistently with the definition of the radio signal which typically is the maximum field strength of the radio pulse. Second, the average impact of noise on radio pulse measurements at individual antennas is studied for LOPES. It is shown that a correct treatment of noise is especially important at low signal-to-noise ratios: noise can be the dominant source of uncertainty for pulse height and time measurements, and it can systematically flatten the slope of lateral distributions. The presented method can also be transfered to other experiments in radio and acoustic detection of cosmic rays and neutrinos.Comment: 4 pages, 6 figures, submitted to NIM A, Proceedings of ARENA 2010, Nantes, Franc

2008-2009 President\u27s Report

The Linfield College President\u27s Annual Report is a collection of information about the year in review, including academics, student life and athletics, enrollment, finances, philanthropy, and leadership

Large scale cosmic-ray anisotropy with KASCADE

The results of an analysis of the large scale anisotropy of cosmic rays in the PeV range are presented. The Rayleigh formalism is applied to the right ascension distribution of extensive air showers measured by the KASCADE experiment.The data set contains about 10^8 extensive air showers in the energy range from 0.7 to 6 PeV. No hints for anisotropy are visible in the right ascension distributions in this energy range. This accounts for all showers as well as for subsets containing showers induced by predominantly light respectively heavy primary particles. Upper flux limits for Rayleigh amplitudes are determined to be between 10^-3 at 0.7 PeV and 10^-2 at 6 PeV primary energy.Comment: accepted by The Astrophysical Journa

Primary Proton Spectrum of Cosmic Rays measured with Single Hadrons

The flux of cosmic-ray induced single hadrons near sea level has been measured with the large hadron calorimeter of the KASCADE experiment. The measurement corroborates former results obtained with detectors of smaller size if the enlarged veto of the 304 m^2 calorimeter surface is encounted for. The program CORSIKA/QGSJET is used to compute the cosmic-ray flux above the atmosphere. Between E_0=300 GeV and 1 PeV the primary proton spectrum can be described with a power law parametrized as dJ/dE_0=(0.15+-0.03)*E_0^{-2.78+-0.03} m^-2 s^-1 sr^-1 TeV^-1. In the TeV region the proton flux compares well with the results from recent measurements of direct experiments.Comment: 13 pages, accepted by Astrophysical Journa

KASCADE: Astrophysical results and tests of hadronic interaction models

KASCADE is a multi-detector setup to get redundant information on single air shower basis. The information is used to perform multiparameter analyses to solve the threefold problem of the reconstruction of (i)the unknown primary energy, (ii) the primary mass, and (iii) to quantify the characteristics of the hadronic interactions in the air-shower development. In this talk recent results of the KASCADE data analyses are summarized concerning cosmic ray anisotropy studies, determination of flux spectra for different primary mass groups, and approaches to test hadronic interaction models. Neither large scale anisotropies nor point sources were found in the KASCADE data set. The energy spectra of the light element groups result in a knee-like bending and a steepening above the knee. The topology of the individual knee positions shows a dependency on the primary particle. Though no hadronic interaction model is fully able to describe the multi-parameter data of KASCADE consistently, the more recent models or improved versions of older models reproduce the data better than few years ago.Comment: to appear in Nucl. Phys. B (Proc. Suppl.), Proc. of the XIII ISVHECRI, Pylos 2004 - with a better quality of the figure

KASCADE-Grande Limits on the Isotropic Diffuse Gamma-Ray Flux between 100 TeV and 1 EeV

KASCADE and KASCADE-Grande were multi-detector installations to measure individual air showers of cosmic rays at ultra-high energy. Based on data sets measured by KASCADE and KASCADE-Grande, 90% C.L. upper limits to the flux of gamma-rays in the primary cosmic ray flux are determined in an energy range of ${10}^{14} - {10}^{18}$ eV. The analysis is performed by selecting air showers with a low muon content as expected for gamma-ray-induced showers compared to air showers induced by energetic nuclei. The best upper limit of the fraction of gamma-rays to the total cosmic ray flux is obtained at $3.7 \times {10}^{15}$ eV with $1.1 \times {10}^{-5}$. Translated to an absolute gamma-ray flux this sets constraints on some fundamental astrophysical models, such as the distance of sources for at least one of the IceCube neutrino excess models.Comment: Published in The Astrophysical Journal, Volume 848, Number 1. Posted on: October 5, 201