90 research outputs found
Ontogenetic study of a myelin-derived fraction with 2′:3′-cyclic nucleotide 3′-phosphodydrolase activity higher than that of myelin
A Neuron-Glial Perspective for Computational Neuroscience
International audienceThere is growing excitement around glial cells, as compelling evidence point to new, previously unimaginable roles for these cells in information processing of the brain, with the potential to affect behavior and higher cognitive functions. Among their many possible functions, glial cells could be involved in practically every aspect of the brain physiology in health and disease. As a result, many investigators in the field welcome the notion of a Neuron-Glial paradigm of brain function, as opposed to Ramon y Cayal's more classical neuronal doctrine which identifies neurons as the prominent, if not the only, cells capable of a signaling role in the brain. The demonstration of a brain-wide Neuron-Glial paradigm however remains elusive and so does the notion of what neuron-glial interactions could be functionally relevant for the brain computational tasks. In this perspective, we present a selection of arguments inspired by available experimental and modeling studies with the aim to provide a biophysical and conceptual platform to computational neuroscience no longer as a mere prerogative of neuronal signaling but rather as the outcome of a complex interaction between neurons and glial cells
Protein and enzyme distribution in microsomal and myelin fractions from rat and jimpy mouse brain.
Myelin basic proteins in myelin subfractions from normal and quaking mice.
The relative proportions of four myelin basic proteins (preL, L, preS,S) were determined in myelin subfractions prepared from the forebrains of quaking and littermate control mice. The distribution pattern of each protein was similar in both mutant and control fractions. The S component was the only basic protein present in low amounts in myelin from the mutant
Membrane Proteins of the Nervous System : Demonstration of Different Protein Profiles in Whole Brain and its Subcellular Particles
Immunological evidence for the presence of myelin-related integral proteins in the CNS of hagfish and lamprey
Distribution of lipid synthesizing enzymes, 2?,3?-cyclic nucleotide 3?-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development
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