Rural Land Use Mapping by Satellite: A Case Study of Region D COG, North Carolina

One of the most important pieces of data necessary to develop an adequate analytical base for most land use and other natural resource planning is an existing land use map. The U.S. Department of Housing and Urban Development (HUD), through its "701" comprehensive planning regulations, mandated that all applicants for HUD "701" funds have a substantially completed land use element prior to August 22, 1977. HUD "701" was one of the major sources of planning funds for the Region D Council of Governments. To comply with these regulations and continue to receive funds. Region D developed a regional land use plan for the 1,615,000 acres in its seven-county area in northwestern North Carolina. Because planning is a relatively new concept in western North Carolina, staff personnel were preoccupied with grantsmanship for local governments and land use and natural resource education programs. It was not feasible to employ additional staff on a short term basis because Region D received only $31,000 of HUD "701" funds. Yet, to comply with the federal regulations, an accurate existing land use map had to be acquired within the budgetary and time constraints

Patent Litigation in Europe

We compare patent litigation cases across four European jurisdictions—Germany, the UK (England and Wales), France, The Netherlands—using case-level data gathered from cases filed in the four jurisdictions during the period 2000–2008. Overall, we find substantial differences across jurisdictions in terms of caseloads—notably, courts in Germany hear by far the largest number of cases, not only in absolute terms, but also when taking macro-economic indicators into account—and we further find important cross-country variances in terms of case outcomes. Moreover, we show empirically that a considerable number of patents are litigated across multiple European jurisdictions; and further, that in the majority of these cases divergent case outcomes are reached across the different jurisdictions, suggesting that the long-suspected problem of inconsistency of decision-making in European patent litigation is in fact real. Finally, we note that the coming into force of the Unified Patent Court in Europe may, in the long term, help to alleviate this inconsistency problem

Ekternalitas PT. AMP Plantation terhadap masyarakat Nagari Bawan Kecamatan Ampek Nagari Kabupaten Agam

PT. AMP Plantation merupakan perusahaan yang bergerak dibidang produksi minyak goreng bersumber dari kelapa sawit berdiri ditahun 1994. Tujuan dari penelitian ini untuk mengidentifikasi eksternalitas setelah adanya Perusahaan tersebut. Jenis penelitian ini dengan data primer yang dikumpulkan dengan dokumentasi dan wawancara pada seratus responden. Metode yang digunakan dalam penelitian ini metode cross tab. Hasil penelitian ini menunjukkan bahwa terdapat eksternalitas terhadap pendapatan, eksternalitas terhadap kesehatan, eksternalitas terhadap pendidikan, eksternalitas terhadap sarana. Kata kunci: ekstrenalitas, pendapatan, kesehatan, pendidikan, saran

Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis

© 2020 The Author(s). The choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms the blood-CSF barrier (BCSFB) and separates the blood from the cerebrospinal fluid (CSF). In addition to its role as a physical barrier, the CP functions in CSF secretion, transport of nutrients into the central nervous system (CNS) and a gated point of entry of circulating immune cells into the CNS. Aging and neurodegeneration have been reported to affect CP morphology and function and increase protein leakage from blood to the CSF. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with both upper and lower motor neuron loss, as well as altered proteomic and metabolomic signatures in the CSF. The role of the BCSFB and the CP in ALS is unknown. Here we describe a transcriptomic and ultrastructural analysis of BCSFB and CP alterations in human postmortem tissues from ALS and non-neurologic disease controls. ALS-CP exhibited widespread disruptions in tight junctional components of the CP epithelial layer and vascular integrity. In addition, we detected loss of pericytes around ALS blood vessels, accompanied by activation of platelet aggregation markers vWF and Fibrinogen, reminiscent of vascular injury. To investigate the immune component of ALS-CP, we conducted a comprehensive analysis of cytokines and chemokine panels in CP lysates and found a significant down-regulation of M-CSF and V-CAM1 in ALS, as well as up-regulation of VEGF-A protein. This phenotype was accompanied by an infiltration of MERTK positive macrophages into the parenchyma of the ALS-CP when compared to controls. Taken together, we demonstrate widespread structural and functional disruptions of the BCSFB in human ALS increasing our understanding of the disease pathology and identifying potential new targets for ALS therapeutic development

Darboux Coordinates and Liouville-Arnold Integration in Loop Algebras

Darboux coordinates are constructed on rational coadjoint orbits of the positive frequency part \wt{\frak{g}}^+ of loop algebras. These are given by the values of the spectral parameters at the divisors corresponding to eigenvector line bundles over the associated spectral curves, defined within a given matrix representation. A Liouville generating function is obtained in completely separated form and shown, through the Liouville-Arnold integration method, to lead to the Abel map linearization of all Hamiltonian flows induced by the spectral invariants. Serre duality is used to define a natural symplectic structure on the space of line bundles of suitable degree over a permissible class of spectral curves, and this is shown to be equivalent to the Kostant-Kirillov symplectic structure on rational coadjoint orbits. The general construction is given for $\frak{g}=\frak{gl}(r)$ or $\frak{sl}(r)$, with reductions to orbits of subalgebras determined as invariant fixed point sets under involutive automorphisms. The case $\frak{g=sl}(2)$ is shown to reproduce the classical integration methods for finite dimensional systems defined on quadrics, as well as the quasi-periodic solutions of the cubically nonlinear Schr\"odinger equation. For $\frak{g=sl}(3)$, the method is applied to the computation of quasi-periodic solutions of the two component coupled nonlinear Schr\"odinger equation.Comment: 61 pg

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer's disease

Singularities of bi-Hamiltonian systems

We study the relationship between singularities of bi-Hamiltonian systems and algebraic properties of compatible Poisson brackets. As the main tool, we introduce the notion of linearization of a Poisson pencil. From the algebraic viewpoint, a linearized Poisson pencil can be understood as a Lie algebra with a fixed 2-cocycle. In terms of such linearizations, we give a criterion for non-degeneracy of singular points of bi-Hamiltonian systems and describe their types

A multilevel neo-institutional analysis of infection prevention and control in English hospitals: coerced safety culture change?

Despite committed policy, regulative and professional efforts on healthcare safety, little is known about how such macro-interventions permeate organisations and shape culture over time. Informed by neo-institutional theory, we examined how inter-organisational influences shaped safety practices and inter-subjective meanings following efforts for coerced culture change. We traced macro-influences from 2000 to 2015 in infection prevention and control (IPC). Safety perceptions and meanings were inductively analysed from 130 in-depth qualitative interviews with senior- and middle-level managers from 30 English hospitals. A total of 869 institutional interventions were identified; 69% had a regulative component. In this context of forced implementation of safety practices, staff experienced inherent tensions concerning the scope of safety, their ability to be open and prioritisation of external mandates over local need. These tensions stemmed from conflicts among three co-existing institutional logics prevalent in the NHS. In response to requests for change, staff flexibly drew from a repertoire of cognitive, material and symbolic resources within and outside their organisations. They crafted 'strategies of action', guided by a situated assessment of first-hand practice experiences complementing collective evaluations of interventions such as 'pragmatic', 'sensible' and also 'legitimate'. Macro-institutional forces exerted influence either directly on individuals or indirectly by enriching the organisational cultural repertoire

Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease: A Retrospective Cohort Study

Data from an autosomal dominant Alzheimer disease (ADAD) kindred were used to track the longitudinal trajectory of cognitive decline associated with preclinical ADAD and explore factors that may modify the rate of cognitive decline