You think this is funny?!: Analyzing the emotional response of the audience on insult humor in noontime shows

Previous research on Philippine humor failed to address specifically the insult humor so prevalent in local context. This study seeks to bridge a knowledge gap on the taste of the local audience for insult humor. Focus group discussions were conducted with audiences of a local noontime show known for a liberal employment of insult humor on the participants of the show. Subsequent examinations of the focus group discussions show certain themes dominant in the collected transcripts, namely, Techniques, Acceptance, and Source of Relief under Internal Processes. Insult Humor as Source of Amusement, Perceptions of Superiority and Bluntness in Delivering Jokes under Perception of the Audience on Insult Humor, and Culture and Accustomed to Humor Style under Insult Humor Dominant in Philippine Media. The results indicated that contrary to previous studies, insult humor elicits a positive emotional response from the audience, instead of having a negative effect on them. Numerous possible explanations as to why such results came about are discussed

MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters

Using an experimental model of NASH induced by a methionine-choline-deficient (MCD) diet, we investigated whether changes occur in serum and tissue levels of asymmetric dimethylarginine (ADMA). Male Wistar rats underwent NASH induced by 8-week feeding with an MCD diet. Serum and hepatic biopsies at 2, 4 and 8 weeks were taken, and serum enzymes, ADMA and nitrate/nitrite (NOx), were evaluated. Hepatic biopsies were used for mRNA and protein expression analysis of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) and protein methyltransferases (PRMT-1), enzymes involved in ADMA metabolism and synthesis, respectively, and ADMA transporters (CAT-1, CAT-2A and CAT-2B). Lipid peroxides (TBARS), glutathione, ATP/ADP and DDAH activity were quantified. An increase in serum AST and ALT was detected in MCD animals. A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet. An increase in serum NOx and no changes in protein expression in DDAH-1 and CAT-1 and higher content in CAT-2 and PRMT-1 were found at 8 weeks. Hepatic DDAH activity decreased with a concomitant increase in oxidative stress, as demonstrated by high TBARS levels and low glutathione content. In conclusion, a decrease in serum and tissue ADMA levels in the MCD rats was found associated with a reduction in DDAH activity due to the marked oxidative stress observed. Changes in ADMA levels and its transporters are innovative factors in the onset and progression of hepatic alterations correlated with MCD diet-induced NASH

Critical barriers to environmental management system implementation in the Nigerian construction industry

This is an accepted manuscript of an article published by Springer in Environmental Management, available online: https://doi.org/10.1007/s00267-021-01473-y The accepted version of the publication may differ from the final published version.The impact of different hazardous substances of the construction industry being released to the environment is alarming. This constitutes an adverse effect on the quality of life of construction workers and the populace at large. To reduce this menace, Environmental Management System (EMS) was put in place. Meanwhile, the implementation of EMS in the Nigerian construction industry (NCI) is not certain. This study, therefore, investigated the barriers to EMS implementation in the NCI to group them into a smaller form, i.e., fewer numbers. A questionnaire survey was developed and administered to construction professionals in Nigeria using a purposive sampling technique. The retrieved 106 copies of the questionnaires were subjected to both descriptive and inferential statistics such as mean score, standard deviation, analysis of variance test, post hoc test and exploratory factor analysis. An exploratory factor analysis was conducted three times to identify the critical barriers to EMS implementation in the NCI. The study findings reveal three main categories of barriers affecting EMS implementation, namely; (1) knowledge barrier; (2) process barrier; and (3) culture and management barrier. The study concluded that the three factors indicate the major cardinal barriers that could describe the impediment of EMS in the NCI. It was recommended that the training of construction professionals is important to enhance improvement culture in the NCI