6,180 research outputs found
Fatty-acid uptake in prostate cancer cells using dynamic microfluidic raman technology
It is known that intake of dietary fatty acid (FA) is strongly correlated with prostate cancer progression but is highly dependent on the type of FAs. High levels of palmitic acid (PA) or arachidonic acid (AA) can stimulate the progression of cancer. In this study, a unique experimental set-up consisting of a Raman microscope, coupled with a commercial shear-flow microfluidic system is used to monitor fatty acid uptake by prostate cancer (PC-3) cells in real-time at the single cell level. Uptake of deuterated PA, deuterated AA, and the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were monitored using this new system, while complementary flow cytometry experiments using Nile red staining, were also conducted for the validation of the cellular lipid uptake. Using this novel experimental system, we show that DHA and EPA have inhibitory effects on the uptake of PA and AA by PC-3 cells
Numerical Modelling of Instantaneous Plate Tectonics
Assuming lithospheric plates to be rigid, we systematically invert 68 spreading rates, 62 fracture zones trends and 10^6 earthquake slip vectors simultaneously to obtain a self-consistent model of instantaneous relative motions for eleven major plates. The inverse problem is linearized and solved iteratively by a maximum likelihood procedure. Because the uncertainties in the data are small, Gaussian statistics are shown to be adequate. The use of a linear theory permits (1) the calculation of the uncertainties in the various angular velocity vectors caused by uncertainties in the data, and (2) quantitative examination of the distribution of information within the data set.
The existence of a self-consistent model satisfying all the data is strong justification of the rigid plate assumption. Slow movement between North and South America is shown to be resolvable.
We then invert the trends of 20 linear island chains and aseismic ridges under the assumptions that they represent the directions of plate motions over a set of hot spots fixed with respect to each other. We conclude that these hot spots have had no significant relative motions in the last 10 My
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Serving GODAE Data and Products to the Ocean Community
The Global Ocean Data Assimilation Experiment (GODAE [http://
www.godae.org]) has spanned a decade of rapid technological development. The ever-increasing volume and diversity of oceanographic data produced by in situ instruments, remote-sensing platforms, and computer simulations have driven
the development of a number of innovative technologies that are essential for connecting scientists with the data that they need. This paper gives an overview of the technologies that have been developed and applied in the course of GODAE, which now provide users of oceanographic data with the capability to discover, evaluate, visualize, download, and analyze data from all over the world. The key to this
capability is the ability to reduce the inherent complexity of oceanographic data by providing a consistent, harmonized view of the various data products. The challenges of data serving have been addressed over the last 10 years through the cooperative skills and energies of many individuals
Knot homology via derived categories of coherent sheaves II, sl(m) case
Using derived categories of equivariant coherent sheaves we construct a knot
homology theory which categorifies the quantum sl(m) knot polynomial. Our knot
homology naturally satisfies the categorified MOY relations and is
conjecturally isomorphic to Khovanov-Rozansky homology. Our construction is
motivated by the geometric Satake correspondence and is related to Manolescu's
by homological mirror symmetry.Comment: 51 pages, 9 figure
LoCuSS: The steady decline and slow quenching of star formation in cluster galaxies over the last four billion years
We present an analysis of the levels and evolution of star formation activity
in a representative sample of 30 massive galaxy clusters at 0.15<z<0.30 from
the Local Cluster Substructure Survey (LoCuSS), combining wide-field Spitzer
24um data with extensive spectroscopy of cluster members. The specific-SFRs of
massive (M>10^10 M_sun) star-forming cluster galaxies within r200 are found to
be systematically 28% lower than their counterparts in the field at fixed
stellar mass and redshift, a difference significant at the 8.7-sigma level.
This is the unambiguous signature of star formation in most (and possibly all)
massive star-forming galaxies being slowly quenched upon accretion into massive
clusters, their SFRs declining exponentially on quenching time-scales in the
range 0.7-2.0 Gyr. We measure the mid-infrared Butcher-Oemler effect over the
redshift range 0.0-0.4, finding rapid evolution in the fraction (f_SF) of
massive (M_K3M_sun/yr, of the
form f_SF (1+z)^7.6. We dissect the origins of the Butcher-Oemler effect,
revealing it to be due to the combination of a ~3x decline in the mean
specific-SFRs of star-forming cluster galaxies since z~0.3 with a ~1.5x
decrease in number density. Two-thirds of this reduction in the specific-SFRs
of star-forming cluster galaxies is due to the steady cosmic decline in the
specific-SFRs among those field galaxies accreted into the clusters. The
remaining one-third reflects an accelerated decline in the star formation
activity of galaxies within clusters. The slow quenching of star-formation in
cluster galaxies is consistent with a gradual shut down of star formation in
infalling spiral galaxies as they interact with the intra-cluster medium via
ram-pressure stripping or starvation mechanisms. We find no evidence for the
build-up of cluster S0 bulges via major nuclear star-burst episodes.Comment: 24 pages, 12 figures. Accepted for publication in Ap
Star formation in the massive cluster merger Abell 2744
We present a comprehensive study of star-forming (SF) galaxies in the HST
Frontier Field recent cluster merger A2744 (z=0.308). Wide-field,
ultraviolet-infrared (UV-IR) imaging enables a direct constraint of the total
star formation rate (SFR) for 53 cluster galaxies, with SFR{UV+IR}=343+/-10
Msun/yr. Within the central 4 arcmin (1.1 Mpc) radius, the integrated SFR is
complete, yielding a total SFR{UV+IR}=201+/-9 Msun/yr. Focussing on obscured
star formation, this core region exhibits a total SFR{IR}=138+/-8 Msun/yr, a
mass-normalised SFR{IR} of Sigma{SFR}=11.2+/-0.7 Msun/yr per 10^14 Msun and a
fraction of IR-detected SF galaxies f{SF}=0.080(+0.010,-0.037). Overall, the
cluster population at z~0.3 exhibits significant intrinsic scatter in IR
properties (total SFR{IR}, Tdust distribution) apparently unrelated to the
dynamical state: A2744 is noticeably different to the merging Bullet cluster,
but similar to several relaxed clusters. However, in A2744 we identify a trail
of SF sources including jellyfish galaxies with substantial unobscured SF due
to extreme stripping (SFR{UV}/SFR{IR} up to 3.3). The orientation of the trail,
and of material stripped from constituent galaxies, indicates that the passing
shock front of the cluster merger was the trigger. Constraints on star
formation from both IR and UV are crucial for understanding galaxy evolution
within the densest environments.Comment: Accepted by MNRAS. 12 pages, 7 figures (high resolution versions of
Figs. 1 & 2 are available in the published PDF
Cosmic dance in the Shapley Concentration Core - I. A study of the radio emission of the BCGs and tailed radio galaxies
The Shapley Concentration () covers several degrees in the
Southern Hemisphere, and includes galaxy clusters in advanced evolutionary
stage, groups of clusters in the early stages of merger, fairly massive
clusters with ongoing accretion activity, and smaller groups located in
filaments in the regions between the main clusters. With the goal to
investigate the role of cluster mergers and accretion on the radio galaxy
population, we performed a multi-wavelength study of the BCGs and of the
galaxies showing extended radio emission in the cluster complexes of Abell 3528
and Abell 3558. Our study is based on a sample of 12 galaxies. We observed the
clusters with the GMRT at 235, 325 and 610 MHz, and with the VLA at 8.46 GHz.
We complemented our study with the TGSS at 150 MHz, the SUMSS at 843 MHz and
ATCA at 1380, 1400, 2380, and 4790 MHz data. Optical imaging with ESO-VST and
mid-IR coverage with WISE are also available for the host galaxies. We found
deep differences in the properties of the radio emission of the BCGs in the two
cluster complexes. The BCGs in the A3528 complex and in A3556, which are
relaxed cool-core objects, are powerful active radio galaxies. They also
present hints of restarted activity. On the contrary, the BCGs in A3558 and
A3562, which are well known merging systems, are very faint, or quiet, in the
radio band. The optical and IR properties of the galaxies are fairly similar in
the two complexes, showing all passive red galaxies. Our study shows remarkable
differences in the radio properties of the BGCs, which we relate to the
different dynamical state of the host cluster. On the contrary, the lack of
changes between such different environments in the optical band suggests that
the dynamical state of galaxy clusters does not affect the optical counterparts
of the radio galaxies, at least over the life-time of the radio emission.Comment: 24 pages, 11 figures, accepted for publication in Astronomy &
Astrophysic
Tests of Statistical Significance and Background Estimation in Gamma Ray Air Shower Experiments
In this paper we discuss several methods of significance calculation and
point out the limits of their applicability. We then introduce a self
consistent scheme for source detection and discuss some of its properties. The
method allows incorporating background anisotropies by vetoing existing small
scale regions on the sky and compensating for known large scale anisotropies.
By giving an example using Milagro gamma ray observatory we demonstrate how the
method can be employed to relax the detector stability assumption. Two
practical implementations of the method are discussed. The method is universal
and can be used with any large field-of-view detector, where the object of
investigation, steady or transient, point or extended, traverses its field of
view.Comment: 12 pages, 7 figures. Submitted to ApJ, submission number: 5833
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