Acoustically driven ferromagnetic resonance

Surface acoustic waves (SAW) in the GHz frequency range are exploited for the all-elastic excitation and detection of ferromagnetic resonance (FMR) in a ferromagnetic/ferroelectric (nickel/lithium niobate) hybrid device. We measure the SAW magneto-transmission at room temperature as a function of frequency, external magnetic field magnitude, and orientation. Our data are well described by a modified Landau-Lifshitz-Gilbert approach, in which a virtual, strain-induced tickle field drives the magnetization precession. This causes a distinct magnetic field orientation dependence of elastically driven FMR that we observe in both model and experiment.Comment: 4 page

The galactic magnetic field in the quasar 3C216

Multifrequency polarimetric observations made with the Very Long Baseline Array of the quasar 3C216 reveal the presence of Faraday rotation measures (RMs) in excess of 2000 rad/m**2 in the source rest frame, in the arc of emission located at ~ 140 mas from the core. Rotation measures in the range -300 - +300 rad/m**2 are detected in the inner 5 mas (~30 parsecs). while the rotation measures near the core can be explained as due to a magnetic field in the narrow line region, we favor the interpretation for the high RM in the arc as due to a ``local'' Faraday screen, produced in a shock where the jet is deflected by the interstellar medium of the host galaxy. Our results indicate that a galacit magnetic field of the order of 50 microGauss on a scale greater than 100 pc must be present in the galactic medium.Comment: 23 pages, 3 tables, 11 figures. To appear on The Astronomical Journal, November 1999 Issu

Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS)

.Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements. Covariation studies and phylogenetic analysis exploring the potential structure of RNA11 of rotaviruses suggested that, besides the previously predicted "modified panhandle" structure, the 5' and 3' termini of one of the isoforms of the bovine rotavirus UKtc strain may interact to form a tRNA-like structure (TRLS). Such TRLSs have been identified in RNAs of plant viruses, where they are important for enhancing replication and packaging. However, using tRNA mimicry assays (in vitro aminoacylation and 3'- adenylation), we found no biochemical evidence for tRNA-like functions of RNA11. Capping, synthetic 3' adenylation and manipulation of divalent cation concentrations did not change this finding. NMR studies on a 5'- and 3'-deletion construct of RNA11 containing the putative intra-strand complementary sequences supported a predominant panhandle structure and did not conform to a cloverleaf fold despite the strong evidence for a predicted structure in this conserved region of the viral RNA. Additional viral or cellular factors may be needed to stabilise it into a form with tRNA-like properties

The determinants of election to the United Nations Security Council

This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s11127-013-0096-4.The United Nations Security Council (UNSC) is the foremost international body responsible for the maintenance of international peace and security. Members vote on issues of global importance and consequently receive perks—election to the UNSC predicts, for instance, World Bank and IMF loans. But who gets elected to the UNSC? Addressing this question empirically is not straightforward as it requires a model that allows for discrete choices at the regional and international levels; the former nominates candidates while the latter ratifies them. Using an original multiple discrete choice model to analyze a dataset of 180 elections from 1970 to 2005, we find that UNSC election appears to derive from a compromise between the demands of populous countries to win election more frequently and a norm of giving each country its turn. We also find evidence that richer countries from the developing world win election more often, while involvement in warfare lowers election probability. By contrast, development aid does not predict election

Final report on accomplishments of a Task Force on Campus Bridging sponsored workshop: Campus Leadership Engagement in Building a Coherent Campus Cyberinfrastructure

In 2010, the National Science Foundation (NSF) awarded a grant of $49,840 to the University of North Carolina Chapel Hill to organize a workshop on the topic of campus cyberinfrastructure with the title “Campus Bridging Taskforce Sponsored Workshop: Campus Leadership Engagement in Building a Coherent Campus Cyberinfrastructure.” This report discusses the contents of the full workshop report to the NSF as well as the accomplishments and outcomes reported via the NSF’s online reporting system.This material is based upon work supported by the National Science Foundation (NSF) under Grant No. 1059812 to the University of North Carolina at Chapel Hill, with Patrick Dreher as principal investigator and Craig Stewart, James Pepin, Guy Almes, and Michael Mundrane as co-principal investigators. Stewart’s involvement was supported by the Indiana University Pervasive Technology Institute, which is supported in part by the Lilly Endowment, Inc. (a private charitable trust). Any opinions, findings and conclusions, or recommendations expressed in this material are those of the author(s), and do not necessarily reflect the views of the NSF or the Lilly Endowment

A search for linear polarization in the active galactic nucleus 3C 84 at 239 and 348 GHz

We report a search for linear polarization in the active galactic nucleus (AGN) 3C 84 (NGC 1275) at observed frequencies of 239 GHz and 348 GHz, corresponding to rest-frame frequencies of 243 GHz and 354 GHz. We collected polarization data with the IRAM Plateau de Bure Interferometer via Earth rotation polarimetry. We do not detect linear polarization. Our analysis finds 3-sigma upper limits on the degree of polarization of 0.5% and 1.9% at 239 GHz and 348 GHz, respectively. We regard the influence of Faraday conversion as marginal, leading to expected circular polarizations <0.3%. Assuming depolarization by a local Faraday screen, we constrain the rotation measure, as well as the fluctuations therein, to be 10^6 rad/m^2. From this we estimate line-of-sight magnetic field strengths of >100 microG. Given the physical dimensions of 3C 84 and its observed structure, the Faraday screen appears to show prominent small-scale structure, with \DeltaRM > 10^6 rad/m^2 on projected spatial scales <1 pc.Comment: 7 pages, 4 figures. Accepted by MNRA

Corruption in Privatization and Governance Regimes

(ISSN 1827-3580

Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements

IT-101, a cyclodextrin polymer-based nanoparticle containing camptothecin, is in clinical development for the treatment of cancer. Multiorgan pharmacokinetics and accumulation in tumor tissue of IT-101 is investigated by using PET. IT-101 is modified through the attachment of a 1,4,7,10-tetraazacyclododecane-1,4,7-Tris-acetic acid ligand to bind ^(64)Cu^(2+). This modification does not affect the particle size and minimally affects the surface charge of the resulting nanoparticles. PET data from ^(64)Cu-labeled IT-101 are used to quantify the in vivo biodistribution in mice bearing Neuro2A s.c. tumors. The ^(64)Cu-labeled IT-101 displays a biphasic plasma elimination. Approximately 8% of the injected dose is rapidly cleared as a low-molecular-weight fraction through the kidneys. The remaining material circulates in plasma with a terminal half-life of 13.3 h. Steadily increasing concentrations, up to 11% injected dose per cm^3, are observed in the tumor over 24 h, higher than any other tissue at that time. A 3-compartment model is used to determine vascular permeability and nanoparticle retention in tumors, and is able to accurately represent the experimental data. The calculated tumor vascular permeability indicates that the majority of nanoparticles stay intact in circulation and do not disassemble into individual polymer strands. A key assumption to modeling the tumor dynamics is that there is a “sink” for the nanoparticles within the tumor. Histological measurements using confocal microscopy show that IT-101 localizes within tumor cells and provides the sink in the tumor for the nanoparticles