Implications of a DK Molecule at 2.32 GeV

We discuss the implications of a possible quasinuclear DK bound state at 2.32 GeV. Evidence for such a state was recently reported in D_s^+pi^o by the BaBar Collaboration. We first note that a conventional quark model c-sbar assignment is implausible, and then consider other options involving multiquark systems. An I=0 c sbar n nbar baryonium assignment is one possibility. We instead favor a DK meson molecule assignment, which can account for the mass and quantum numbers of this state. The higher-mass scalar c-sbar state expected at 2.48 GeV is predicted to have a very large DK coupling, which would encourage formation of an I=0 DK molecule. Isospin mixing is expected in hadron molecules, and a dominantly I=0 DK state with some I=1 admixture could explain both the narrow total width of the 2.32 GeV state as well as the observed decay to D_s^+ pi^o. Additional measurements that can be used to test this and related scenarios are discussed.Comment: 6 pages, 1 figur

Dynamics of hadron strong production and decay

We generalize results of lattice QCD to determine the spin-dependent symmetries and factorization properties of meson production in OZI allowed processes. This explains some conjectures previously made in the literature about axial meson decays and gives predictions for exclusive decays of vector charmonia, including ways of establishing the structure of Y(4260) and Y(4325) from their S-wave decays. Factorization gives a selection rule which forbids $e^+e^- \to D^* D_2$ near threshold with the tensor meson in helicity 2. The relations among amplitudes for double charmonia production \e^+e^-\to \psi\chi_{0,1,2} are expected to differ from the analagous relations among light flavour production such as \e^+e^-\to \omega f_{0,1,2}.Comment: 13 pages; journal versio

Options for the SELEX state D_{s\J}^+(2632)

We consider possible assignments for the D_{s\J}^+(2632), which was recently reported in D$_s^+\eta$ and D$^0$K$^+$ final states by the SELEX Collaboration at Fermilab. The most plausible quark model assignment for this state is the first radial excitation ($2^3\S_1$) of the $c\bar s$ D$_s^*(2112)$, although the predicted mass and strong decay branching fractions for this assignment are not in agreement with the SELEX data. The reported dominance of D$_s\eta$ over DK appears especially problematic. An intriguing similarity to the K$^*(1414)$ is noted. $2^3\S_1$--^3\D_1 configuration mixing is also considered, and we find that this effect is unlikely to resolve the branching fraction discrepancy. Other interpretations as a $c\bar s$-hybrid or a two-meson molecule are also considered, but appear unlikely. Thus, if this state is confirmed, it will require reconsideration of the systematics of charmed meson spectroscopy and strong decays.Comment: 6 revtex4 pages, 2 eps figure

Pentaquark implications for exotic mesons

If the exotic baryon $\Theta^+(1540)$ is a correlated $udud\bar{s}$ with $J^P = {1/2}^+$, then there should exist an exotic meson, $J^P = 1^-$ $\vartheta^+ (S=+2)$ $\to K^+K^0$ $\sim 1.6$GeV with width $O(10-100)$MeV. The $\pi_1(1400;1600)$ may be broad members of {\bf 10} $\pm$ \10bar in such a picture. Vector mesons in the 1.4 - 1.7GeV mass range are also compared with this picture

A chromomagnetic mechanism for the X(3872) resonance

The chromomagnetic interaction, with proper account for flavour-symmetry breaking, is shown to explain the mass and coupling properties of the X(3872) resonance as a $J^{PC}$ = 1$^{++}$ state consisting of a heavy quark-antiquark pair and a light one. It is crucial to introduce all the spin-colour configurations compatible with these quantum numbers and diagonalise the chromomagnetic interaction in this basis. This approach thus differs from the molecular picture $D\bar {D}*$ and from the diquark-antidiquark picture.Comment: 4 pages - revtex4 - Typos corrected, refs. added, to be published in Phys. Rev.

Decisive Search for a Diquark-Antidiquark Meson with Hidden Strangeness

Diquark-antidiquark states are expected to exist as a natural complement of mesons and baryons. Although they were predicted long ago, and some candidates were found experimentally, none has, as yet, been reliably identified. We suggest that the search for the so-called $C(1480)$-meson in reactions such as photoproduction $\gamma N\rightarrow\phi\pi N$ and $K N \rightarrow \phi \pi \Lambda$ should provide a decisive way to settle this issue. Estimates of the cross sections are given using present experimental information on the C-meson and assuming its diquark-antidiquark structure. Sizable cross sections are predicted (of the order of 0.1 $\mu$b for photoproduction and of the order of 0.1 mb for $KN$ at the maximum with an insignificant background). Failure to find this kind of signal would imply that the C-meson is {\it not} a diquark-antidiquark state.Comment: 9 pages in LATex + 6 figs. (available from authers upon request), IUHET-269/9

Radiative decays: a new flavour filter

Radiative decays of the $1^3D_1$ orbital excitations of the $\rho$, $\omega$ and $\phi$ to the scalars $f_0(1370)$, $f_0(1500)$ and $f_0(1710)$ are shown to provide a flavour filter, clarifying the extent of glueball mixing in the scalar states. A complementary approach to the latter is provided by the radiative decays of the scalar mesons to the ground-state vectors $\rho$, $\omega$ and $\phi$. Discrimination among different mixing scenarios is strong.Comment: 12 pages, 1 table, 0 figure

Spin-dependent Parton Distributions from Polarized Structure Function Data

In the past year, polarized deep inelastic scattering experiments at CERN and SLAC have obtained structure function measurements off proton, neutron and deuteron targets at a level of precision never before achieved. The measurements can be used to test the Bjorken and Ellis-Jaffe sum rules, and also to obtain information on the parton distributions in polarized nucleons. We perform a global leading-order QCD fit to the proton deep inelastic data in order to extract the spin-dependent parton distributions. By using parametric forms which are consistent with theoretical expectations at large and small $x$, we find that the quark distributions are now rather well constrained. We assume that there is no significant intrinsic polarization of the strange quark sea. The data are then consistent with a modest amount of the proton's spin carried by the gluon, although the shape of the gluon distribution is not well constrained, and several qualitatively different shapes are suggested. The spin-dependent distributions we obtain can be used as input to phenomenological studies for future polarized hadron-hadron and lepton-hadron colliders.Comment: 23 pages, DTP/94/3

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.

BACKGROUND: An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind, controlled study. METHODS: We randomly assigned 161 patients who had active rheumatoid arthritis despite treatment with methotrexate to receive one of four treatments: oral methotrexate (> or =10 mg per week) (control); rituximab (1000 mg on days 1 and 15); rituximab plus cyclophosphamide (750 mg on days 3 and 17); or rituximab plus methotrexate. Responses defined according to the criteria of the American College of Rheumatology (ACR) and the European League against Rheumatism (EULAR) were assessed at week 24 (primary analyses) and week 48 (exploratory analyses). RESULTS: At week 24, the proportion of patients with 50 percent improvement in disease symptoms according to the ACR criteria, the primary end point, was significantly greater with the rituximab-methotrexate combination (43 percent, P=0.005) and the rituximab-cyclophosphamide combination (41 percent, P=0.005) than with methotrexate alone (13 percent). In all groups treated with rituximab, a significantly higher proportion of patients had a 20 percent improvement in disease symptoms according to the ACR criteria (65 to 76 percent vs. 38 percent, P< or =0.025) or had EULAR responses (83 to 85 percent vs. 50 percent, P< or =0.004). All ACR responses were maintained at week 48 in the rituximab-methotrexate group. The majority of adverse events occurred with the first rituximab infusion: at 24 weeks, serious infections occurred in one patient (2.5 percent) in the control group and in four patients (3.3 percent) in the rituximab groups. Peripheral-blood immunoglobulin concentrations remained within normal ranges. CONCLUSIONS: In patients with active rheumatoid arthritis despite methotrexate treatment, a single course of two infusions of rituximab, alone or in combination with either cyclophosphamide or continued methotrexate, provided significant improvement in disease symptoms at both weeks 24 and 48