Evaluation of Metaverse integration of freight fluidity measurement alternatives using fuzzy Dombi EDAS model

Developments in transportation systems, changes in consumerism trends, and conditions such as COVID-19 have increased both the demand and the load on freight transportation. Since various companies are transporting goods all over the world to evaluate the sustainability, speed, and resiliency of freight transportation systems, data and freight fluidity measurement systems are needed. In this study, an integrated decision-making model is proposed to advantage prioritize the freight fluidity measurement alternatives. The proposed model is composed of two main stages. In the first stage, the Dombi norms based Logarithmic Methodology of Additive Weights (LMAW) is used to find the weights of criteria. In the second phase, an extended Evaluation based on the Distance from Average Solution (EDAS) method with Dombi unction for aggregation is presented to determine the final ranking results of alternatives. Three freight fluidity measurement alternatives are proposed, namely doing nothing, integrating freight activities into Metaverse for measuring fluidity, and forming global governance of freight activities for measuring fluidity through available data. Thirteen criteria, which are grouped under four main aspects namely technology, governance, efficiency, and environmental sustainability, and a case study at which a ground framework is formed for the experts to evaluate the alternatives considering the criteria are used in the multi-criteria decision-making process. The results of the study indicate that integrating freight activities into Metaverse for measuring fluidity is the most advantageous alternative, whereas doing nothing is the least advantageous one

STATUS OF WILD BOAR (Sus scrofa L.) ON THE ISLAND KRK

Divlja svinja u Republici Hrvatskoj autohtona je vrsta. Zakonski spada u krupnu, lovostajem zaštićenu vrstu divljači. Krajem prošlog stoljeća tjerana nagonom za širenjem svoje vrste plivanjem dolazi na otok. Krk je danas veoma kvalitetno stanište za život krupne divljači. Obilje hrane, vode, gusta vegetacija, raznolikost staništa, mir u lovištu, kvalitetno tlo, zapuštanje poljoprivrednih površina koje se pretvaraju u šikaru, rezultira stalnim prirastom postojeće divljači kao i zauzimanje prostora od nove pristigle divljači. Nekada je otok izgledao bitno drugačije nego kako izgleda danas. Obrađivao se svaki komadić zemlje, a danas se većina prepušta sukcesiji. Nova situacija u staništu uvjetuje i pojavu novih životinjskih vrsta. Upravo ovakva situacija pogoduje krupnoj, a ne odgovara sitnoj divljači. Divlje svinje nalaze se i u nelovnim površinama, gdje dolaze zbog hrane i mira, budući se tu zbog zakonskih propisa ne vrši lov. Nelovne površine služe kao rezervat iz kojeg nastanjuju najkvalitetnija staništa. «Crna divljač» na otoku Krku smatra se nepoželjnom vrstom divljači, te se sukladno naredbama ministarstva lovi cijele godine, bez obzira na spol i dob. Zbog odstrjela krmača vodilja, kvalitetnog staništa i velikog odstrjela bucanje i prašenje traje tijekom cijele lovne godine. Divljač pokušava opstati koristeći svoje prirodne mehanizme za očuvanje svoje vrste. U devet lovnih godina s otoka je izlučeno 3.602 grla divljih svinja. Kvalitetu staništa potvrđuje i snaga trofeja odstreljenih veprova, koja zbog nepravilnog odstrjela opada. Želja za potpunim izlučenjem divlje svinje s otoka Krka borba je sa prirodom, a za sada priroda uvijek pobjeđuje. Da li će tako biti i ovoga puta pokazati će budućnostThe wild boar is a native species in the Republic of Croatia. This large game animal is protected by law in closed season. At the end of the last century, driven by instinct to expand its species, it swam from the mainland to the island of Krk. Today Krk provides an excellent habitat for large game animals. Due to an abundance of food, water, dense vegetation, habitat diversity, peaceful hunting ground, fertile ground, abandoned farming areas which have been turning into thick underbrush, the existing game is on a constant increase while new arrivals crowd the existing habitat. The island has changed much and the landscape is not what it was once. Each parcel of land was once cultivated, while today it is left to succession. The new situation in the habitat has caused the emergence of new animal species. It is exactly this type of situation that suits the large and not the small game animals. Wild boars are found in areas not designated for hunting where they come to feed in a peaceful environment since by law hunting is prohibited there. Areas not designated for hunting serve as a game refuge and as such are considered to be habitats of the highest quality. The “black game” on the island of Krk is considered an undesirable type of game animal and pursuant to regulations may be hunted throughout the year, regardless of its sex or age. Due to the eradication of dominant female wild boars, excellent habitat and the large number of killings, mating lasts throughout the entire hunting season. The wild boar tries to survive using its natural mechanisms to preserve its species. In the nine years of hunting 3,602 head of wild boars were eradicated. The quality of the habitat is measured by the number of male boars that were killed as trophies, this being on the decline due to irregular killings. The desire to completely eradicate the wild boar from the island of Krk is a battle against nature and nature is winning, for now. Will this be the case now, only the future will tell

Expression of MK-1 and RegⅣ and its clinicopathological significances in the benign and malignant lesions of gallbladder

<p>Abstract</p> <p>Background</p> <p>To study the expression of MK-1 and RegⅣ and to detect their pathological significances in benign and malignant lesions of gallbladder.</p> <p>Methods</p> <p>The expression of MK-1 and RegⅣ was detected by immunohistochemical method in paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp (n = 15), and chronic cholecystitis (n = 35).</p> <p>Results</p> <p>The positive rate of MK-1 or RegⅣ expression was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues (χ²_MK-1= 18.76, <it>P </it>< 0.01; χ²_RegⅣ= 9.92, <it>P </it>< 0.01), denomatous polyp (χ²_MK-1= 9.49, <it>P </it>< 0.01; χ²_RegⅣ= 8.59, <it>P </it>< 0.01) and chronic cholecystitis (χ²_MK-1= 24.11, <it>P </it>< 0.01; χ²_RegⅣ= 19.24, <it>P </it>< 0.01). The positive cases of MK-1 and/or RegⅣ in the benign lesions showed moderately- or severe-atypical hyperplasia of gallbladder epitheli. The positive rates of MK-1 were significantly higher in the cases of well-differentiated adenocarcinoma, no-metastasis of lymph node, and no-invasiveness of regional tissues than those in the ones of differentiated adenocarcinoma, metastasis of lymph node, and invasiveness of regional tissues in gallbladder adenocarcinoma (<it>P </it>< 0.05 or <it>P </it>< 0.01). On the contrary, the positive rates of RegⅣ were significantly lower in the cases of well-differentiated adenocarcinoma, no-metastasis of lymph node, and no-invasiveness of regional tissues than those in the ones of differentiated adenocarcinoma, metastasis of lymph node, and invasiveness of regional tissues in gallbladder adenocarcinoma (<it>P </it>< 0.05 or <it>P </it>< 0.01). Univariate Kaplan-Meier analysis showed that decreased expression of MK-1 (<it>P </it>= 0.09) or increased expression of RegⅣ (<it>P </it>= 0.003) was associated with decreased overall survival. Multivariate Cox regression analysis showed that decreased expression of MK-1 (<it>P </it>= 0.033) and increased expression of RegⅣ (<it>P </it>= 0.008) was an independent prognostic predictor in gallbladder adenocarcinoma.</p> <p>Conclusions</p> <p>The expression of MK-1 and/or RegⅣ might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.</p

Aspartame induces angiogenesis in vitro and in vivo models

Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study is to evaluate the effect of aspartame on angiogenesis in vivo chick chorioallantoic membrane (CAM) and wound-healing models as well as in vitro 2,3-bis-2H-tetrazolium-5-carboxanilide (XTT) and tube formation assays. In CAM assay, aspartame increased angiogenesis in a concentration-dependent manner. Compared with the control group, aspartame has significantly increased vessel proliferation (p < 0.001). In addition, in vivo rat model of skin wound-healing study showed that aspartame group had better healing than control group, and this was statistically significant at p < 0.05. There was a slight proliferative effect of aspartame on human umbilical vein endothelial cells on XTT assay in vitro, but it was not statistically significant; and there was no antiangiogenic effect of aspartame on tube formation assay in vitro. These results provide evidence that aspartame induces angiogenesis in vitro and in vivo; so regular use may have undesirable effect on susceptible cases. © The Author(s) 2015

Using breath carbon monoxide to validate self-reported tobacco smoking in remote Australian Indigenous communities

Background: This paper examines the specificity and sensitivity of a breath carbon monoxide (BCO) test and\ud optimum BCO cutoff level for validating self-reported tobacco smoking in Indigenous Australians in Arnhem Land,\ud Northern Territory (NT).\ud \ud Methods: In a sample of 400 people (≥16 years) interviewed about tobacco use in three communities, both selfreported\ud smoking and BCO data were recorded for 309 study participants. Of these, 249 reported smoking tobacco\ud within the preceding 24 hours, and 60 reported they had never smoked or had not smoked tobacco for ≥6\ud months. The sample was opportunistically recruited using quotas to reflect age and gender balances in the\ud communities where the combined Indigenous populations comprised 1,104 males and 1,215 females (≥16 years).\ud Local Indigenous research workers assisted researchers in interviewing participants and facilitating BCO tests using\ud a portable hand-held analyzer.\ud \ud Results: A BCO cutoff of ≥7 parts per million (ppm) provided good agreement between self-report and BCO\ud (96.0% sensitivity, 93.3% specificity). An alternative cutoff of ≥5 ppm increased sensitivity from 96.0% to 99.6% with no change in specificity (93.3%). With data for two self-reported nonsmokers who also reported that they smoked\ud cannabis removed from the analysis, specificity increased to 96.6%.\ud \ud Conclusion: In these disadvantaged Indigenous populations, where data describing smoking are few, testing for\ud BCO provides a practical, noninvasive, and immediate method to validate self-reported smoking. In further studies\ud of tobacco smoking in these populations, cannabis use should be considered where self-reported nonsmokers\ud show high BCO

Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature

<p>Abstract</p> <p>Background</p> <p>Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties.</p> <p>Methods</p> <p>We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm). We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials.</p> <p>Results and discussion</p> <p>Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.</p> <p>Conclusion</p> <p>The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.</p

Development of a clinical decision model for thyroid nodules

<p>Abstract</p> <p>Background</p> <p>Thyroid nodules represent a common problem brought to medical attention. Four to seven percent of the United States adult population (10–18 million people) has a palpable thyroid nodule, however the majority (>95%) of thyroid nodules are benign. While, fine needle aspiration remains the most cost effective and accurate diagnostic tool for thyroid nodules in current practice, over 20% of patients undergoing FNA of a thyroid nodule have indeterminate cytology (follicular neoplasm) with associated malignancy risk prevalence of 20–30%. These patients require thyroid lobectomy/isthmusectomy purely for the purpose of attaining a definitive diagnosis. Given that the majority (70–80%) of these patients have benign surgical pathology, thyroidectomy in these patients is conducted principally with diagnostic intent. Clinical models predictive of malignancy risk are needed to support treatment decisions in patients with thyroid nodules in order to reduce morbidity associated with unnecessary diagnostic surgery.</p> <p>Methods</p> <p>Data were analyzed from a completed prospective cohort trial conducted over a 4-year period involving 216 patients with thyroid nodules undergoing ultrasound (US), electrical impedance scanning (EIS) and fine needle aspiration cytology (FNA) prior to thyroidectomy. A Bayesian model was designed to predict malignancy in thyroid nodules based on multivariate dependence relationships between independent covariates. Ten-fold cross-validation was performed to estimate classifier error wherein the data set was randomized into ten separate and unique train and test sets consisting of a training set (90% of records) and a test set (10% of records). A receiver-operating-characteristics (ROC) curve of these predictions and area under the curve (AUC) were calculated to determine model robustness for predicting malignancy in thyroid nodules.</p> <p>Results</p> <p>Thyroid nodule size, FNA cytology, US and EIS characteristics were highly predictive of malignancy. Cross validation of the model created with Bayesian Network Analysis effectively predicted malignancy [AUC = 0.88 (95%CI: 0.82–0.94)] in thyroid nodules. The positive and negative predictive values of the model are 83% (95%CI: 76%–91%) and 79% (95%CI: 72%–86%), respectively.</p> <p>Conclusion</p> <p>An integrated predictive decision model using Bayesian inference incorporating readily obtainable thyroid nodule measures is clinically relevant, as it effectively predicts malignancy in thyroid nodules. This model warrants further validation testing in prospective clinical trials.</p