14 research outputs found
Primary staging and follow-up in melanoma patients – monocenter evaluation of methods, costs and patient survival
- Author
- A Ardizzoni
- A Blum
- A Tregnaghi
- AM Eggermont
- BJ Kjeldsen
- CA Baughan
- CE Orfanos
- CL Huang
- CR Shumate
- D Schadendorf
- DJ Fader
- DS Reintgen
- E G Jung
- E Hormbrey
- G Goerz
- GM Zartman
- H Tsao
- J Northover
- JB Romero
- M Bastien
- M Rosen
- M Rosselli Del Turco
- M Szedlak
- M Weiss
- MH Terhune
- MI Ross
- MM Mooney
- MM Mooney
- N Bassères
- N Provost
- NC Conference
- P Rumke
- PA Kersey
- S Fusi
- SJ Soong
- T Khansur
- TJ Dicker
- U Hofmann
- W Rittgen
- W-J Poo-Hwu
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
In a German cohort of 661 melanoma patients the performance, costs and survival benefits of staging methods (history and physical examination; chest X-ray; ultrasonography of the abdomen; high resolution sonography of the peripheral lymph nodes) were assessed at initial staging and during follow-up of stage I/II+III disease. At initial staging, 74% (23 out of 31) of synchronous metastases were first detected by physical examination followed by sonography of the lymph nodes revealing 16% (5 out of 31). Other imaging methods were less efficient (Chest X-ray: one out of 31; sonography of abdomen: two out of 31). Nearly 24% of all 127 first recurrences and 18% of 73 second recurrences developed in patients not participating in the follow-up programme. In follow-up patients detection of first or second recurrence were attributed to history and physical examination on a routine visit in 47 and 52% recurrences, respectively, and to routine imaging procedures in 21 and 17% of cases, respectively. Lymph node sonography was the most successful technical staging procedure indicating 13% of first relapses, but comprised 24% of total costs of follow-up in stage I/II. Routine imaging comprised nearly 50% of total costs for follow-up in stage I/II and in stage III. The mode of detecting a relapse (‘patient vs. doctor-diagnosed’ or ‘symptomatic vs asymptomatic’) did not significantly influence patients overall survival. Taken together, imaging procedures for routine follow-up in stage I/II and stage III melanoma patients were inefficient and not cost-efficient
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
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- A Todd
- A Tomas
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- A Zak
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- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
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- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
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- Annarita Giliberti
- Annemarie B Docherty
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- Antonio Di Biagio
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- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
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- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
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- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
IMPROVING ICE FORMATION BY ADDITIVE FOR COLD ENERGY STORAGE
- Author
- Publication venue
- 'World Scientific Pub Co Pte Lt'
- Publication date
- Field of study
Mid-infrared surface transmitting and detecting quantum cascade device for gas-sensing
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sign inversion in the superconducting order parameter of LiFeAs inferred from Bogoliubov quasiparticle interference
- Author
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- Field of study
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
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- Publication venue
- country:DEU
- Publication date
- 01/01/2021
- Field of study
A BHR Composite Network-Based Visualization Method for Deformation Risk Level of Underground Space
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks
- Author
- A-L Barabási
- Andrey Rzhetsky
- Anthony Szedlak
- C Looman
- Carlo Piermarocchi
- D Tautz
- E Ong
- E Wingender
- EN Olson
- EV Koonin
- G Dennis
- G Manning
- GA Wray
- Giovanni Paternostro
- H Chen
- HB Fraser
- I Lee
- JH Laity
- JT Daub
- LC Freeman
- Li Liu
- M Rubinov
- MEJ Newman
- MH Schaefer
- MW Hahn
- Nicholas Smith
- P Ballario
- P Dehal
- PA Fujita
- S Ciftci-Yilmaz
- S Kumar
- SA Teichmann
- T Sauka-Spengler
- TA Steitz
- V Anantharaman
- V Latora
- V van Noort
- VD Blondel
- Y Niimura
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Surveillance, control and management of infections in intensive care units in Southern Europe, Turkey and Iran--a prospective multicenter point prevalence study
- Author
- Afkhamzadeh A
- Ahmed SS
- Ahmetagic S
- Akata F
- Akkoyunlu Y
- Alp E
- Altındis S
- Askarian M
- Aslan T
- Balik I
- Beeching N
- Beovic B
- Bozkurt F
- Cami A
- Carevic B
- Cosic G
- Cottle L
- Csato G
- Csomos A
- Elaldi N
- Erdem H
- Farahangiz S
- Farrokhnia M
- Grgic S
- Grozdanovski K
- Harxhi A
- Hosoglu S
- Inan A
- Ivanova P
- Jazbec A
- Jereb M
- Kaya S
- Koksal I
- Koluder N
- Korten V
- Leblebicioglu H
- Luca C
- Metodiev K
- Mirkovic T
- Moradi F
- Moravveji SA
- Müller M
- Naber K.
- Nechifor M
- Oncu S
- Petrov N
- Platikanov V
- Raka L
- Shiraly R
- Soltanipour S
- Stefanov C
- Szedlak B
- Vakili M
- Yilmaz G
- Publication venue
- 'Elsevier BV'
- Publication date
- 26/11/2013
- Field of study
PMID = 2426995