Study to investigate the effects of ionizing radiation on transistor surfaces Third quarterly report, period ending, 31 Mar. 1966

Ionizing radiation effects on transistor surface

Civil tiltrotor missions and applications. Phase 2: The commercial passenger market

The commercial passenger market for the civil tiltrotor was examined in phase 2. A market responsive commercial tiltrotor was found to be technically feasible, and a significant worldwide market potential was found to exist for such an aircraft, especially for relieving congestion in urban area-to-urban area service and for providing cost effective hub airport feeder service. Potential technical obstacles of community noise, vertiport area navigation, surveillance, and control, and the pilot/aircraft interface were determined to be surmountable. Nontechnical obstacles relating to national commitment and leadership and development of ground and air infrastructure were determined to be more difficult to resolve; an innovative public/private partnership is suggested to allow coordinated development of an initial commercial tiltrotor network to relieve congestion in the crowded US Northeast corridor by the year 2000

Study to investigate the effects of ionizing radiation on transistor surfaces Fourth quarterly report, period ending Jun. 30, 1966

Ionizing radiation effects on transistor surfaces in vacuum or ambient nitrogen environmen

Database Search Strategies for Proteomic Data Sets Generated by Electron Capture Dissociation Mass Spectrometry

Large data sets of electron capture dissociation (ECD) mass spectra from proteomic experiments are rich in information; however, extracting that information in an optimal manner is not straightforward. Protein database search engines currently available are designed for low resolution CID data, from which Fourier transform ion cyclotron resonance (FT-ICR) ECD data differs significantly. ECD mass spectra contain both z-prime and z-dot fragment ions (and c-prime and c-dot); ECD mass spectra contain abundant peaks derived from neutral losses from charge-reduced precursor ions; FT-ICR ECD spectra are acquired with a larger precursor m/z isolation window than their low-resolution CID counterparts. Here, we consider three distinct stages of postacquisition analysis: (1) processing of ECD mass spectra prior to the database search; (2) the database search step itself and (3) postsearch processing of results. We demonstrate that each of these steps has an effect on the number of peptides identified, with the postsearch processing of results having the largest effect. We compare two commonly used search engines: Mascot and OMSSA. Using an ECD data set of modest size (3341 mass spectra) from a complex sample (mouse whole cell lysate), we demonstrate that search results can be improved from 630 identifications (19% identification success rate) to 1643 identifications (49% identification success rate). We focus in particular on improving identification rates for doubly charged precursors, which are typically low for ECD fragmentation. We compare our presearch processing algorithm with a similar algorithm recently developed for electron transfer dissociation (ETD) data

2MASS J06164006-6407194: The First Outer Halo L Subdwarf

We present the serendipitous discovery of an L subdwarf, 2MASS J06164006-6407194, in a search of the Two Micron All Sky Survey for T dwarfs. Its spectrum exhibits features indicative of both a cool and metal poor atmosphere including a heavily pressured-broadened K I resonant doublet, Cs I and Rb I lines, molecular bands of CaH, TiO, CrH, FeH, and H2O, and enhanced collision induced absorption of H2. We assign 2MASS 0616-6407 a spectral type of sdL5 based on a comparison of its red optical spectrum to that of near solar-metallicity L dwarfs. Its high proper motion (mu =1.405+-0.008 arcsec yr-1), large radial velocity (Vrad = 454+-15 km s-1), estimated uvw velocities (94, -573, 125) km s-1 and Galactic orbit with an apogalacticon at ~29 kpc are indicative of membership in the outer halo making 2MASS 0616-6407 the first ultracool member of this population.Comment: Accepted for publication in Ap

SEASAT: A satellite scatterometer illumination times of selected in situ sites

A list of times that the SEASAT A Satellite Scatterometer (SASS) illuminated from directly above or directly abeam, selected surface sites where in situ winds were measured is provided. The list is ordered by the Greenwich Mean Time (GMT) of the midpoint of the illumination period (hit time) for a given surface site. The site identification, the orbit number and the direction from the subtrack in which the truth lies are provided. The accuracy of these times depends in part upon the ascending node times, which are estimated to be within +.1 sec, and on the illumination time relative to the ascending node, which is estimated to be within +6 seconds. The uncertainties in the times provided were judged to be sufficiently small to allow efficient and accurate extraction of SASS and in situ data at the selected surface sites. The list contains approximately six thousand hit times from 61 geographically dispersed sites

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life

Mammals transport blood through a high-pressure, closed vascular network and lymph through a low-pressure, open vascular network. These vascular networks connect at the lymphovenous (LV) junction, where lymph drains into blood and an LV valve (LVV) prevents backflow of blood into lymphatic vessels. Here we describe an essential role for platelets in preventing blood from entering the lymphatic system at the LV junction. Loss of CLEC2, a receptor that activates platelets in response to lymphatic endothelial cells, resulted in backfilling of the lymphatic network with blood from the thoracic duct (TD) in both neonatal and mature mice. Fibrin-containing platelet thrombi were observed at the LVV and in the terminal TD in wild-type mice, but not Clec2-deficient mice. Analysis of mice lacking LVVs or lymphatic valves revealed that platelet-mediated thrombus formation limits LV backflow under conditions of impaired valve function. Examination of mice lacking integrin-mediated platelet aggregation indicated that platelet aggregation stabilizes thrombi that form in the lymphatic vascular environment to prevent retrograde blood flow. Collectively, these studies unveil a newly recognized form of hemostasis that functions with the LVV to safeguard the lymphatic vascular network throughout life

Self-Regulation of Solar Coronal Heating Process via Collisionless Reconnection Condition

I propose a new paradigm for solar coronal heating viewed as a self-regulating process keeping the plasma marginally collisionless. The mechanism is based on the coupling between two effects. First, coronal density controls the plasma collisionality and hence the transition between the slow collisional Sweet-Parker and the fast collisionless reconnection regimes. In turn, coronal energy release leads to chromospheric evaporation, increasing the density and thus inhibiting subsequent reconnection of the newly-reconnected loops. As a result, statistically, the density fluctuates around some critical level, comparable to that observed in the corona. In the long run, coronal heating can be represented by repeating cycles of fast reconnection events (nano-flares), evaporation episodes, and long periods of slow magnetic stress build-up and radiative cooling of the coronal plasma.Comment: 4 pages; Phys. Rev. Lett., in pres

Effective dynamics using conditional expectations

The question of coarse-graining is ubiquitous in molecular dynamics. In this article, we are interested in deriving effective properties for the dynamics of a coarse-grained variable $\xi(x)$, where $x$ describes the configuration of the system in a high-dimensional space $\R^n$, and $\xi$ is a smooth function with value in $\R$ (typically a reaction coordinate). It is well known that, given a Boltzmann-Gibbs distribution on $x \in \R^n$, the equilibrium properties on $\xi(x)$ are completely determined by the free energy. On the other hand, the question of the effective dynamics on $\xi(x)$ is much more difficult to address. Starting from an overdamped Langevin equation on $x \in \R^n$, we propose an effective dynamics for $\xi(x) \in \R$ using conditional expectations. Using entropy methods, we give sufficient conditions for the time marginals of the effective dynamics to be close to the original ones. We check numerically on some toy examples that these sufficient conditions yield an effective dynamics which accurately reproduces the residence times in the potential energy wells. We also discuss the accuracy of the effective dynamics in a pathwise sense, and the relevance of the free energy to build a coarse-grained dynamics