A search for 183-GHz emission from water in late-type stars

A search was made for 183 GHz line emission from water vapor in the direction of twelve Mira and two semiregular variables. Upper limits to the emission are in the range of 2000 to 5000 Jy. It is estimated that thermal emission from the inner regions of late type stellar envelopes will be on the order of ten Jy. Maser emission, according to one model, would be an order of magnitude stronger. From the limited set sampled, the possibility of very strong maser emission at 183 GHz cannot yet be ruled out

183 GHz water line variation: An energetic outburst in orion KL

Observations of the 3(13)-2(20) transition of water vapor in the direction of Ori MC1 in 1980 February show a 50% flux increase and an apparent additional red shift of approximately 2 km/s relative to the line observed in 1977 December. From a detailed examination of the amplitude and frequency calibration, it appears unlikely that the effect is due to systematic error. The increase is attributed to the appearance of a new component at a velocity of 12 km/s with respect to the local standard of rest. The new component also has broad wings. Increased emission from a region in the high-velocity core of Ori MC1 can be due either to additional far-IR radiation to pump the 1983 GHz transition or to a change in the physical conditions in the gas. Statistical equilibrium calculations using the large-velocity-gradient formalism were carried out to develop a model for the emission. The calculations support a model in which the gas in the region of enhanced emission is hotter than the dust. The temporal coincidence between the 183 GHZ increase and the 22 GH1 water maser outburst suggests a common, impulsive cause, which has heated the gas in a part of the HV source, enhancing the emission in both transitions

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.

To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nucleotide-binding oligomerization domain leucine-rich repeat family of pattern recognition receptors, which detect cytoplasmic microbial products. We report that mouse macrophages restricted L. pneumophila replication and initiated a proinflammatory program of cell death when flagellin contaminated their cytosol. Nuclear condensation, membrane permeability, and interleukin-1beta secretion were triggered by type IV secretion-competent bacteria that encode flagellin. The macrophage response to L. pneumophila was independent of Toll-like receptor signaling but correlated with Naip5 function and required caspase 1 activity. The L. pneumophila type IV secretion system provided only pore-forming activity because listeriolysin O of Listeria monocytogenes could substitute for its contribution. Flagellin monomers appeared to trigger the macrophage response from perforated phagosomes: once heated to disassemble filaments, flagellin triggered cell death but native flagellar preparations did not. Flagellin made L. pneumophila vulnerable to innate immune mechanisms because Naip5+ macrophages restricted the growth of virulent microbes, but flagellin mutants replicated freely. Likewise, after intratracheal inoculation of Naip5+ mice, the yield of L. pneumophila in the lungs declined, whereas the burden of flagellin mutants increased. Accordingly, macrophages respond to cytosolic flagellin by a mechanism that requires Naip5 and caspase 1 to restrict bacterial replication and release proinflammatory cytokines that control L. pneumophila infection

Body composition estimated by bioelectrical impedance analyses is diminished by prenatal stress in neonatal lambs and by heat stress in feedlot wethers

Body composition correlates to carcass value in livestock, which makes the ability to accurately estimate body composition in the live animal beneficial (Berg and Marchello, 1994). Bioelectrical impedance analysis (BIA) is a clinical tool used to assess body composition in humans (Lukaski et al., 1985), but its use in livestock has been minimal. Lean and fat content contribute to profitability for livestock producers, and poor body composition can be caused by stress that occurs either during in utero development (De Blasio et al., 2007) or during postnatal growth (Boyd et al., 2015). Maternal hyperthermia-induced placental insufficiency (Brown et al., 2015) and sustained maternal inflammation (Cadaret et al., 2018) are two established causes of intrauterine growth restriction (IUGR). IUGR-born animals are characterized by asymmetrical growth restriction that alters lifelong body composition due to impaired muscle growth capacity (Yates et al., 2018). In addition, acute heat stress during periods of peak postnatal growth can alter body composition in livestock (Boyd et al., 2015). We postulate that BIA can detect these changes in the live animal. Thus, the objective of this study was to determine whether BIA measurements can predict changes to body composition in live neonatal lambs exposed to intrauterine stress and in heat-stressed feedlot lambs

N=4 SYM to Two Loops: Compact Expressions for the Non-Compact Symmetry Algebra of the su(1,1|2) Sector

We begin a study of higher-loop corrections to the dilatation generator of N=4 SYM in non-compact sectors. In these sectors, the dilatation generator contains infinitely many interactions, and therefore one expects very complicated higher-loop corrections. Remarkably, we find a short and simple expression for the two-loop dilatation generator. Our solution for the non-compact su(1,1|2) sector consists of nested commutators of four O(g) generators and one simple auxiliary generator. Moreover, the solution does not require the planar limit; we conjecture that it is valid for any gauge group. To obtain the two-loop dilatation generator, we find the complete O(g^3) symmetry algebra for this sector, which is also given by concise expressions. We check our solution using published results of direct field theory calculations. By applying the expression for the two-loop dilatation generator to compute selected anomalous dimensions and the bosonic sl(2) sector internal S-matrix, we confirm recent conjectures of the higher-loop Bethe ansatz of hep-th/0412188.Comment: 28 pages, v2: additional checks against direct field theory calculations, references added, minor corrections, v3: additional minor correction

Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct

The uppermost aspect of the hair follicle, known as the infundibulum or hair canal, provides a passageway for hair shaft egress and sebum secretion. Recent studies have indicated that the infundibulum and sebaceous ducts are lined by molecularly distinct differentiated cells expressing markers including Keratin 79 and Gata6. Here, we ablated Gata6 from the skin and observed dilation of both the hair canal and sebaceous ducts, independent of gender and hair cycle stage. Constitutive loss of Gata6 yielded only a mild delay in depilation‐induced entry into anagen, while unperturbed mutant mice possessed overtly normal skin and hair. Furthermore, we noted that Keratin 79 and Gata6 expression and localization did not depend upon each other. Our findings implicate Gata6 in maintaining the upper hair follicle and suggest that regulation of this transcription factor may be compromised in pathologies such as acne or infundibular cystic diseases that are characterized by abnormal expansion of this follicular domain.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149235/1/exd13757_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149235/2/exd13757-sup-0001-FigS1-S9.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149235/3/exd13757.pd

The Factorized S-Matrix of CFT/AdS

We argue that the recently discovered integrability in the large-N CFT/AdS system is equivalent to diffractionless scattering of the corresponding hidden elementary excitations. This suggests that, perhaps, the key tool for finding the spectrum of this system is neither the gauge theory's dilatation operator nor the string sigma model's quantum Hamiltonian, but instead the respective factorized S-matrix. To illustrate the idea, we focus on the closed fermionic su(1|1) sector of the N=4 gauge theory. We introduce a new technique, the perturbative asymptotic Bethe ansatz, and use it to extract this sector's three-loop S-matrix from Beisert's involved algebraic work on the three-loop su(2|3) sector. We then show that the current knowledge about semiclassical and near-plane-wave quantum strings in the su(2), su(1|1) and sl(2) sectors of AdS_5 x S^5 is fully consistent with the existence of a factorized S-matrix. Analyzing the available information, we find an intriguing relation between the three associated S-matrices. Assuming that the relation also holds in gauge theory, we derive the three-loop S-matrix of the sl(2) sector even though this sector's dilatation operator is not yet known beyond one loop. The resulting Bethe ansatz reproduces the three-loop anomalous dimensions of twist-two operators recently conjectured by Kotikov, Lipatov, Onishchenko and Velizhanin, whose work is based on a highly complex QCD computation of Moch, Vermaseren and Vogt.Comment: 38 pages, LaTeX, JHEP3.cl

Rubidium atomic funnel

A low-velocity beam of rubidium atoms is produced from a two-dimensional magneto-optic trap or atomic funnel. Atoms from a thermal beam are slowed by chirped laser cooling and then loaded into the funnel. The cold atoms are ejected by moving molasses formed with frequency-shifted laser beams. The resultant atomic beam has a controllable velocity in the range of 3 to 10 m/s, a temperature of 500 μK, and a flux of 1010 atoms/s