3,381 research outputs found
A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now available that slow the rate of lung function decline, trials of these treatments have failed to show improvement in symptoms or quality of life. There is an immediate unmet need for evidenced-based interventions that improve patients' symptom burden and make a difference to everyday living. This study aims to assess the feasibility of conducting a definitive randomised controlled trial of a holistic, complex breathlessness intervention in people with IPF.
Methods and analysis The trial is a two-centre, randomised controlled feasibility trial of a complex breathlessness intervention compared with usual care in patients with IPF. 50 participants will be recruited from secondary care IPF clinics and randomised 1:1 to either start the intervention within 1 week of randomisation (fast-track group) or to receive usual care for 8 weeks before receiving the intervention (wait-list group). Participants will remain in the study for a total of 16 weeks. Outcome measures will be feasibility outcomes, including recruitment, retention, acceptability and fidelity of the intervention. Clinical outcomes will be measured to inform outcome selection and sample size calculation for a definitive trial.
Ethics and dissemination Yorkshire and The Humber – Bradford Leeds Research Ethics Committee approved the study protocol (REC 18/YH/0147). Results of the main trial and all secondary end-points will be submitted for publication in a peer-reviewed journal
General Report — Session 11: Seismic Zonation and Microzonation, Earthquake Risk Assessment, and Earthquake Risk Management
High-resolution contact networks of free-ranging domestic dogs Canis familiaris and implications for transmission of infection
This is the final version. Available on open access from Public Library of Science via the DOI in this recordData Availability: All data and code supporting these analyses are available on Dryad doi:10.5061/dryad.7v62484.Contact patterns strongly influence the dynamics of disease transmission in both human and non-human animal populations. Domestic dogs Canis familiaris are a social species and are a reservoir for several zoonotic infections, yet few studies have empirically determined contact patterns within dog populations. Using high-resolution proximity logging technology, we characterised the contact networks of free-ranging domestic dogs from two settlements (n = 108 dogs, covering >80 % of the population in each settlement) in rural Chad. We used these data to simulate the transmission of an infection comparable to rabies and investigated the effects of including observed contact heterogeneities on epidemic outcomes. We found that dog contact networks displayed considerable heterogeneity, particularly in the duration of contacts and that the network had communities that were highly correlated with household membership. Simulations using observed contact networks had smaller epidemic sizes than those that assumed random mixing, demonstrating the unsuitability of homogenous mixing models in predicting epidemic outcomes. When contact heterogeneities were included in simulations, the network position of the individual initially infected had an important effect on epidemic outcomes. The risk of an epidemic occurring was best predicted by the initially infected individual’s ranked degree, while epidemic size was best predicted by the individual’s ranked eigenvector centrality. For dogs in one settlement, we found that ranked eigenvector centrality was correlated with range size. Our results demonstrate that observed heterogeneities in contacts are important for the prediction of epidemiological outcomes in free-ranging domestic dogs. We show that individuals presenting a higher risk for disease transmission can be identified by their network position and provide evidence that observable traits hold potential for informing targeted disease management strategies.Carter Cente
Minimum Information about a Neuroscience Investigation (MINI) Electrophysiology
This module represents the formalized opinion of the authors and the CARMEN consortium, which identifies the minimum information required to report the use of electrophysiology in a neuroscience study, for submission to the CARMEN system (www.carmen.org.uk).

Epitaxial growth of Cu on Cu(001): experiments and simulations
A quantitative comparison between experimental and Monte Carlo simulation
results for the epitaxial growth of Cu/Cu(001) in the submonolayer regime is
presented. The simulations take into account a complete set of hopping
processes whose activation energies are derived from semi-empirical
calculations using the embedded-atom method. The island separation is measured
as a function of the incoming flux and the temperature. A good quantitative
agreement between the experiment and simulation is found for the island
separation, the activation energies for the dominant processes, and the
exponents that characterize the growth. The simulation results are then
analyzed at lower coverages, which are not accessible experimentally, providing
good agreement with theoretical predictions as well.Comment: Latex document. 7 pages. 3 embedded figures in separate PS files. One
bbl fil
The Dark Side of ROTSE-III Prompt GRB Observations
We present several cases of optical observations during gamma-ray bursts
(GRBs) which resulted in prompt limits but no detection of optical emission.
These limits constrain the prompt optical flux densities and the optical
brightness relative to the gamma-ray emission. The derived constraints fall
within the range of properties observed in GRBs with prompt optical detections,
though at the faint end of optical/gamma flux ratios. The presently accessible
prompt optical limits do not require a different set of intrinsic or
environmental GRB properties, relative to the events with prompt optical
detections.Comment: ApJ accepted. 20 pages in draft manuscript form, which includes 6
pages of tables and 2 figure
Status of the ROTSE-III telescope network
ROTSE-III is a homogeneous worldwide array of 4 robotic telescopes. They were designed to provide optical observations of Îł-ray burst (GRB) afterglows as close as possible to the start of Îł-ray emission. ROTSE-III is fulfilling its potential for GRB science, and provides optical observations for a variety of astrophysical sources in the interim between GRB events
The ArgoNeuT Detector in the NuMI Low-Energy beam line at Fermilab
The ArgoNeuT liquid argon time projection chamber has collected thousands of
neutrino and antineutrino events during an extended run period in the NuMI
beam-line at Fermilab. This paper focuses on the main aspects of the detector
layout and related technical features, including the cryogenic equipment, time
projection chamber, read-out electronics, and off-line data treatment. The
detector commissioning phase, physics run, and first neutrino event displays
are also reported. The characterization of the main working parameters of the
detector during data-taking, the ionization electron drift velocity and
lifetime in liquid argon, as obtained from through-going muon data complete the
present report.Comment: 43 pages, 27 figures, 5 tables - update referenc
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