Beyond the local approximation to exchange and correlation: the role of the Laplacian of the density in the energy density of Si

We model the exchange-correlation (XC) energy density of the Si crystal and atom as calculated by variational Monte Carlo (VMC) methods with a gradient analysis beyond the local density approximation (LDA). We find the Laplacian of the density to be an excellent predictor of the discrepancy between VMC and LDA energy densities in each system. A simple Laplacian-based correction to the LDA energy density is developed by means of a least square fit to the VMC XC energy density for the crystal, which fits the homogeneous electron gas and Si atom without further effort.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let

Meta-analysis of insulin aspart versus regular human insulin used in a basal-bolus regimen for the treatment of diabetes mellitus

Background: The objective of the current study was to compare the efficacy of two different insulin formulations, insulin aspart (IAsp) and regular human insulin (RHI), for prandial insulin coverage with neutral protamine Hagedorn (NPH) insulin as basal insulin using a meta-analysis approach. The primary endpoint was change in A1c over time. Secondary endpoints included incidence of hypoglycemia and postprandial glycemic control. Methods: Clinical trials (Type 1 and Type 2 diabetes) complying with Good Clinical Practice, and with individual patient data, were included in the meta-analysis. Trials were randomized, consisting of (at least) two treatment arms and had a minimum duration of 12 weeks. Estimates were calculated using fixed-effects and random-effects models. Heterogeneity was assessed for each analysis. The effect of baseline parameters on A1c was analyzed in extended simultaneous models. Results: The mean difference in A1c was 0.1% (95% confidence interval [CI] [−0.15; −0.04], P < 0.001) in favor of IAsp. Higher accumulated dose of IAsp, higher age and increased rates of hypoglycemia were associated with improved A1c outcome. Fasting plasma glucose was not significantly different between regimens. Postprandial glucose was significantly lower after treatment with IAsp compared with RHI, but the analysis did present a significant level of heterogeneity (P < 0.001). The overall rate of hypoglycemia was the same with both regimens, but nocturnal hypoglycemia was significantly lower with IAsp. Conclusions: A basal–bolus regimen with IAsp as bolus insulin provided minimal, but statistically significant, improvement in overall glycemic control with a lower rate of nocturnal hypoglycemic episodes, compared with a corresponding regimen with bolus RHI

Modular termination verification for non-blocking concurrency

© Springer-Verlag Berlin Heidelberg 2016.We present Total-TaDA, a program logic for verifying the total correctness of concurrent programs: that such programs both terminate and produce the correct result. With Total-TaDA, we can specify constraints on a thread’s concurrent environment that are necessary to guarantee termination. This allows us to verify total correctness for nonblocking algorithms, e.g. a counter and a stack. Our specifications can express lock- and wait-freedom. More generally, they can express that one operation cannot impede the progress of another, a new non-blocking property we call non-impedance. Moreover, our approach is modular. We can verify the operations of a module independently, and build up modules on top of each other

Rapid Brain Cooling in Intubated Pigs through Nasal Flushing with Oxygen: Prevention of Brain Hyperthermia

Local cooling of the brain by the respiratory air is found in many animal species. The mechanism is based on cooling of the nasal vein blood and heat transfer in the cavernous sinus/carotid artery complex and is therefore not active in anaesthetised, intubated animals. The present experiment was made to investigate the effects of oxygen flushing of the nasal cavities in such animals. Nine anaesthetised, intubated male pigs were used. The temperatures in the third ventricle and rectum were measured continuously. Oxygen was infused into the nasal cavities during 10 min periods interrupted by 10 min without flow. The nasal oxygen flow constantly induced a rapid, reversible and flow dependant decrease in brain temperature: 0.25°C ± 0.04, (n = 2) (mean ± SD, n) at <4 l/min; 1.35°C ± 0.78, (n = 20) at 4–6 l/min; and 1.44°C ± 0.62, (n = 6) at >6 l/min. The ventricle temperature decreased 0.59°C ± 0.23, (n = 8) when the animals were transferred to spontaneous respiration and the tracheal tube removed. It may be possible to protect the brain in intubated animals and humans from heat-induced damages by establishment of nasal flushing

Specifying and Verifying Concurrent Algorithms with Histories and Subjectivity

We present a lightweight approach to Hoare-style specifications for fine-grained concurrency, based on a notion of time-stamped histories that abstractly capture atomic changes in the program state. Our key observation is that histories form a partial commutative monoid, a structure fundamental for representation of concurrent resources. This insight provides us with a unifying mechanism that allows us to treat histories just like heaps in separation logic. For example, both are subject to the same assertion logic and inference rules (e.g., the frame rule). Moreover, the notion of ownership transfer, which usually applies to heaps, has an equivalent in histories. It can be used to formally represent helping---an important design pattern for concurrent algorithms whereby one thread can execute code on behalf of another. Specifications in terms of histories naturally abstract granularity, in the sense that sophisticated fine-grained algorithms can be given the same specifications as their simplified coarse-grained counterparts, making them equally convenient for client-side reasoning. We illustrate our approach on a number of examples and validate all of them in Coq.Comment: 17 page

Early break-up of the Norwegian Channel Ice Stream during the Last Glacial Maximum

We present 18 new cosmogenic ¹⁰Be exposure ages that constrain the breakup time of the Norwegian Channel Ice Stream (NCIS) and the initial retreat of the Scandinavian Ice Sheet from the Southwest coast of Norway following the Last Glacial Maximum (LGM). Seven samples from glacially transported erratics on the island Utsira, located in the path of the NCIS about 400 km up-flow from the LGM ice front position, yielded an average ¹⁰Be age of 22.0 ± 2.0 ka. The distribution of the ages is skewed with the 4 youngest all within the range 20.2–20.8 ka. We place most confidence on this cluster of ages to constrain the timing of ice sheet retreat as we suspect the 3 oldest ages have some inheritance from a previous ice free period. Three additional ages from the adjacent island Karmøy provided an average age of 20.9 ± 0.7 ka, further supporting the new timing of retreat for the NCIS. The ¹⁰Be ages from Utsira and Karmøy suggest that the ice stream broke up about 2000 years earlier than the age assignment based on ¹⁴C ages on foraminifera and molluscs from marine sediment cores. We postulate that the Scandinavian Ice Sheet flowed across the Norwegian Channel to Denmark and onto the North Sea plateau during early phases of the LGM. When the NCIS started to operate this ice supply to the North Sea was cut off and the fast flow of the NCIS also led to a lowering of the ice surface along the Norwegian Channel and thereby drawdown of the entire ice sheet. This facilitated rapid calving of the ice front in the North Sea and we reconstruct a large open bay across the entire northern North Sea by ∼20 ka based on our ¹⁰Be ages in the east and radiocarbon ages from marine cores in the west. Additional ¹⁰Be ages show that the mainland slightly east of the islands Utsira and Karmøy remained ice covered until about 16 ka, indicating almost no net ice-margin retreat for the 4000 years between 20 and 16 ka. After 16 ka the ice margin retreated quickly up-fjord

Deglaciation of the Scandinavian Ice Sheet and a Younger Dryas ice cap in the outer Hardangerfjorden area, southwestern Norway

Understanding past responses of ice sheets to climate change provides an important long-term context for observations of present day, and projected future, ice-sheet change. In this work, we reconstruct the deglaciation of the marine-terminating western margin of the Scandinavian Ice Sheet in the outer Hardangerfjorden area of southwestern Norway, following the Last Glacial Maximum (LGM) until the start of the Holocene. We base our interpretations on a combination of geomorphological mapping using high-resolution (LiDAR) terrain models, 68 new cosmogenic nuclide 10Be exposure ages and radiocarbon-dated lake sediment cores, supported by the stratigraphic position of the 12.1 ka Vedde Ash. We show that even the highest mountain summits in the area (˜1200–1400 m a.s.l.) were ice-covered during the LGM, thus settling debates concerning the Scandinavian Ice Sheet thickness in this region. These summits emerged as nunataqs through the ice sheet about 22–18 ka, potentially owing to upstream ice thinning caused by the break-up and retreat of the Norwegian Channel Ice Stream. Following the break-up of the Norwegian Channel Ice Stream, the ice margin seemingly stabilized at the outermost coast for 3500–5500 years before the mouth of Hardangerfjorden became ice free at c. 14.5 ka. Subsequently, during the Bølling and Allerød periods, the ice sheet retreated rapidly into the inner parts of Hardangerfjorden before a major ice sheet re-advance during the Younger Dryas. We identify and reconstruct a sizeable, independent ice cap on the Ulvanosa mountain massif during the Younger Dryas (YD), a massif that earlier was mapped as covered by the Scandinavian Ice Sheet during the YD. We also document ice-free areas that are more extensive than previously thought between Hardangerfjorden and Matersfjorden during the YD.publishedVersio