Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens

Background Asymptomatic blood donors can transmit human parvovirus B19 (B19V). Methods We assessed the B19V prevalence among a large cohort of blood donations collected in Germany during 2015–2018. Results In total, 167 123 donations were screened for B19V deoxyribonucleic acid with 22 cases of viremia identified (0.013% positive). Infections peaked at a 4-year interval and the highest number of cases occurred in the summer months. All 22 infections were found in rhesus D-antigen-positive donations, suggesting a protective factor in donors who lack this antigen. Conclusions These findings contribute to our understanding of risk factors for B19V infection among central European blood and plasma donors