John M. Cooper Correspondence

Entries include the typed transcripts of correspondence from the Maine State Library to J.W. Arrowsmith, Ltd., investigating the whereabouts of William Sutherland, Cooper\u27s published pseudonym, and typed and handwritten letters from Cooper

Transient optical absorptivity of nitrogen dioxide following pulsed illumination

A knowledge of the time rates for intermediate reactions during the photolysis of nitrogen dioxide enables one to deduce the possible intermediate reactions which are responsible. An experiment has been devised and constructed which will measure the time rates for photochemical reactions occurring in ranges of one micro second to several milliseconds after initiation of a short duration high intensity photolyzing flash. The method proposed utilizes the examination of the decrease of nitrogen dioxide as a means for observing the photolysis of nitrogen dioxide. The experimental apparatus consisting of a source of light for the photolysis of nitrogen dioxide, a flash tube capable of 200 joules of energy per flash, and a detector of the variation of nitrogen dioxide concentration are described. Preliminary results demonstrate that the intermediate mechanism mainly responsible has a reaction time rate associated with it which is much smaller and influences a greater percentage of the nitrogen dioxide molecules than what would be expected with a dissociative process. It is suggested that this greater influence and smaller time rate can be best explained by a collisional energy transfer process

A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

Chronic inflammation can lead to the development of cancers and resolution of inflammation is an ongoing challenge.</p

Quantification of habitat fragmentation reveals extinction risk in terrestrial mammals

Although habitat fragmentation is often assumed to be a primary driver of extinction, global patterns of fragmentation and its relationship to extinction risk have not been consistently quantified for any major animal taxon. We developed high-resolution habitat fragmentation models and used phylogenetic comparative methods to quantify the effects of habitat fragmentation on the world's terrestrial mammals, including 4,018 species across 26 taxonomic Orders. Results demonstrate that species with more fragmentation are at greater risk of extinction, even after accounting for the effects of key macroecological predictors, such as body size and geographic range size. Species with higher fragmentation had smaller ranges and a lower proportion of high-suitability habitat within their range, andmost high-suitability habitat occurred outside of protected areas, further elevating extinction risk. Our models provide a quantitative evaluation of extinction risk assessments for species, allow for identification of emerging threats in species not classified as threatened, and provide maps of global hotspots of fragmentation for the world's terrestrial mammals. Quantification of habitat fragmentation will help guide threat assessment and strategic priorities for global mammal conservation

Simulation of radiation driven wind from disc galaxies

We present 2-D hydrodynamic simulation of rotating galactic winds driven by radiation. We study the structure and dynamics of the cool and/or warm component($T \simeq 10^4$ K) which is mixed with dust. We have taken into account the total gravity of a galactic system that consists of a disc, a bulge and a dark matter halo. We find that the combined effect of gravity and radiation pressure from a realistic disc drives the gas away to a distance of $\sim 5$ kpc in $\sim 37$ Myr for typical galactic parameters. The outflow speed increases rapidly with the disc Eddington parameter $\Gamma_0(=\kappa I/(2 c G \Sigma)$) for $\Gamma_0 \ge 1.5$. We find that the rotation speed of the outflowing gas is $\lesssim 100$ km s$^{-1}$. The wind is confined in a cone which mostly consist of low angular momentum gas lifted from the central region.Comment: 10 pages, 11 figures, Accepted for publication in MNRA

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels

Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to functional outputs are unclear at present. A previous study has established that leptin inhibits the activity of the phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome 10), an important tumor suppressor and modifier of phosphoinositide signaling. In this study we demonstrate that leptin phosphorylates multiple sites on the C-terminal tail of PTEN in hypothalamic and pancreatic β-cells, an action not replicated by insulin. Inhibitors of the protein kinases CK2 and glycogen synthase kinase 3 (GSK3) block leptin-mediated PTEN phosphorylation. PTEN phosphorylation mutants reveal the critical role these sites play in transmission of the leptin signal to F-actin depolymerization. CK2 and GSK3 inhibitors also prevent leptin-mediated F-actin depolymerization and consequent ATP-sensitive K+ channel opening. GSK3 kinase activity is inhibited by insulin but not leptin in hypothalamic cells. Both hormones increase N-terminal GSK3 serine phosphorylation, but in hypothalamic cells this action of leptin is transient. Leptin, not insulin, increases GSK3 tyrosine phosphorylation in both cell types. These results demonstrate a significant role for PTEN in leptin signal transmission and identify GSK3 as a potential important signaling node contributing to divergent outputs for these hormones

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr \u3csup\u3e/\u3c/sup\u3e mice

Copyright © 2018 Burke et al. Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success in reversing existing obesity and metabolic dysregulation. Previous prevention studies demonstrated that the citrus flavonoids, naringenin and nobiletin, protect against obesity and metabolic dysfunction in Ldlr/ mice fed a high-fat cholesterol-containing (HFHC) diet. However, their effects in an intervention model are unknown. In this report, we show that, in Ldlr/ mice with diet-induced obesity, citrus flavonoid supplementation to a HFHC diet reversed existing obesity and adipocyte size and number through enhanced energy expenditure and increased hepatic fatty acid oxidation. Caloric intake was unaffected and no evidence of white adipose tissue browning was observed. Reversal of adiposity was accompanied by improvements in hyperlipidemia, insulin sensitivity, hepatic steatosis, and a modest reduction in blood monocytes. Together, this resulted in atherosclerotic lesions that were unchanged in size, but characterized by reduced macrophage content, consistent with a more stable plaque phenotype. These studies further suggest potential therapeutic utility of citrus flavonoids, especially in the context of existing obesity, metabolic dysfunction, and cardiovascular disease

Magnetohydrodynamic stability of broad line region clouds

Hydrodynamic stability has been a longstanding issue for the cloud model of the broad line region in active galactic nuclei. We argue that the clouds may be gravitationally bound to the supermassive black hole. If true, stabilisation by thermal pressure alone becomes even more difficult. We further argue that if magnetic fields should be present in such clouds at a level that could affect the stability properties, they need to be strong enough to compete with the radiation pressure on the cloud. This would imply magnetic field values of a few Gauss for a sample of Active Galactic Nuclei we draw from the literature. We then investigate the effect of several magnetic configurations on cloud stability in axi-symmetric magnetohydrodynamic simulations. For a purely azimuthal magnetic field which provides the dominant pressure support, the cloud first gets compressed by the opposing radiative and gravitational forces. The pressure inside the cloud then increases, and it expands vertically. Kelvin-Helmholtz and column density instability lead to a filamentary fragmentation of the cloud. This radiative dispersion continues until the cloud is shredded down to the resolution level. For a helical magnetic field configuration, a much more stable cloud core survives with a stationary density histogram which takes the form of a power law. Our simulated clouds develop sub-Alfvenic internal motions on the level of a few hundred km/s.Comment: 16 pages, 11 figures, accepted by MNRAS, Figure 6 updated due to inconsistent linestyles, corrected mistake in Alfven speed formula, some very minor language corrections. The definitive version is available at www.blackwell- synergy.co

Bostonia: The Boston University Alumni Magazine. Volume 11

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs