Understanding the Incidents on Legacy Airlines with Machine Learning: Case Study Top 5 US Arlines

This study aims to analyze aircraft incident data from the Federal Aviation Administration (FAA) between 1978 and to current for the top five largest airlines in the United States. The goal is to predict conditions that have a higher chance of causing injury and to determine the best machine-learning model for this prediction. The target variable of injuries occurred is processed through Machine Learning methods such as Deep Learning, Logistic Regression, and Support Vector Machine. While analyzing and understanding the incidents, the text mining methodology is used in real-world incident remarks reports. The main scope of the study is not only to predict the injuries but also to understand and explain the complex fault mechanism that creates these incidents and recommend actions for these airlines to reduce the number and severity of these incidents by combining inferences between variables with Subject Matter Expertise in the area. This study provides insights into improving safety in the aviation industry, commonalities of injuries, and how it contributes to the literature by predicting injuries in legacy airlines, explaining the patterns that create incidents, and creating prescriptions to reduce injuries that happen on airlines by using explainable Machine Learning models

An exploration into the dual career experiences of the TuksSport High School learner-athlete

The purpose of this research study was to explore the dual career experiences of the TuksSport High School learner-athlete. Adolescent learner-athletes who had all transitioned from disadvantaged communities into the TuksSport High School and TuksSport High School Athletics Academy. This was accomplished through a case study research design which incorporated the use of collages alongside unstructured interviews. Each research participant was required to create collages, which represented their experiences as learner-athletes at the TuksSport High School. Once the collage making process was complete, each participant was interviewed individually, with the focus of the interview set on their completed collages. The researcher transcribed the unstructured interviews and then analysed them using thematic analysis. Through this process it was uncovered that the research participants had experienced significant challenges and opportunities at the TuksSport High School. The findings of this research study indicate that the participants had experiences that corroborated with, differed to or were unique to existing research that has been conducted.Mini Dissertation (MA)--University of Pretoria, 2018.PsychologyMAUnrestricte

Phase II study of neoadjuvant 5-FU + leucovorin + CPT-11 in patients with resectable liver metastases from colorectal adenocarcinoma

BACKGROUND: Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 – 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated that systemic chemotherapy would improve outcomes, particularly in those whose disease is sensitive to the agents administered. One potential advantage of neoadjuvant chemotherapy is that it provides in vivo chemosensitivity data. Response to neoadjuvant chemotherapy could therefore guide adjuvant chemotherapy following resection of liver metastases from colorectal cancer. METHODS AND DESIGN: This is a prospective Phase II evaluation of outcomes in patients with potentially resectable liver metastases. Patients will receive neoadjuvant chemotherapy and will undergo resection. Postoperative chemotherapy will be directed by the degree of response to preoperative chemotherapy. All patients with Stage IV colorectal adenocarcinoma isolated to the liver that have disease that is amenable to complete ablation by resection, radiofrequency ablation, and/or cryoablation will be candidates for the trial. Patients will receive CPT-11 180 mg/m(2 )IV (over 90 minutes) on day 1 with 5-FU 400 mg/m(2 )bolus and 600 mg/m(2 )by 22 hour infusion and calcium folinate 200 mg/m(2 )on days 1 and 2, every 2 weeks. Altogether, six cycles of chemotherapy will be administered. Patients will then undergo resection and/or radiofrequency ablation. Patients who had stable disease or a clinical response with preoperative chemotherapy will receive an additional 12 cycles of CPT-11 180 mg/m(2 )IV (over 90 minutes) on day 1 with 5-FU 400 mg/m(2 )bolus and 600 mg/m(2 )by 22 hour infusion and calcium folinate 200 mg/m(2 )on days 1 and 2 (given every 2 weeks). Patients with resectable disease who had progressive disease during neoadjuvant chemotherapy will receive best supportive care or an alternative agent, at the discretion of the treating physician. Those patients who are not rendered free of disease following the neoadjuvant chemotherapy and surgery will receive best supportive care or an alternative agent, at the discretion of the treating physician. The primary endpoint of the study is disease-free survival. Secondary endpoints include overall survival, safety and feasibility, response to chemotherapy, and quality of life

Remote access to schematic drawings

An electronic information system for storing, transmitting, receiving and displaying electrical circuit schematics is presented. The schematics are binary coded for computer storage and for transmission over telephone grade communications lines. A complete schematic can be transmitted in a matter of a few seconds with no degradation in the image quality. A standard set of schematic symbols and the associated alphanumeric characters are stored at the receiver in the character matrix of a shaped beam tube. Only the information as to the location of each schematic symbol in the character matrix and the organization of the schematic symbols is stored and transmitted.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33071/1/0000457.pd

Short‐term macroinvertebrate recruitment and sediment accumulation: A novel field chamber approach

Stream‐deposited sediment is one of the major stressors affecting stream biota. Several methods exist to quantify stream sediment embeddedness, but they are relatively qualitative and operationally defined. The authors developed a short‐term in situ embeddedness chamber method to measure aquatic insect recruitment and associated sediment accumulation in a more quantitative, better replicated manner. With sediment accumulation and aquatic insect recruitment as endpoints, three exposure periods were evaluated (4, 7, and 14 d) on a low‐order stream (Honey Creek, New Carlisle, Ohio, USA) and a medium‐order stream (Stillwater River, Covington, Ohio, USA). Chamber results show significant positive correlations between newly deposited fine sediment and insect recruitment. Embeddedness was also measured using the more conventional techniques of the Burns method and the U.S. Geological Survey National Water Quality Assessment Program method. This in situ chamber method allows for increased experimental options for assessing the stress of embeddedness and siltation on benthic communities and may prove useful for investigating the resilience of benthic communities after disturbances. Environ. Toxicol. Chem. 2012; 31: 1098–1106. © 2012 SETACPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91097/1/1784_ftp.pd

Optimal Management of Severe/Refractory Asthma

Asthma is a chronic inflammatory disease of the airways, affecting approximately 300 million people worldwide. Asthma results in airway hyperresponsiveness, leading to paroxysmal symptoms of wheeze, cough, shortness of breath, and chest tightness. When these symptoms remain uncontrolled, despite treatment with high doses of inhaled and ingested corticosteroids, asthmatic patients are predisposed to greater morbidity and require more health care support. Treating patients with severe asthma can be difficult and often poses a challenge to physicians when providing ongoing management. This clinical review aims to discuss the definition, prevalence and evaluation of severe asthmatics, and provides a review of the existing pharmacologic and non-pharmacologic treatment options

palaeoverse: A community‐driven R package to support palaeobiological analysis

1. The open-source programming language ‘R' has become a standard tool in the palaeobiologist's toolkit. Its popularity within the palaeobiological community continues to grow, with published articles increasingly citing the usage of R and R packages. However, there are currently a lack of agreed standards for data preparation and available frameworks to support the implementation of such standards. Consequently, data preparation workflows are often unclear and not reproducible, even when code is provided. Moreover, due to a lack of code accessibility and documentation, palaeobiologists are often forced to ‘reinvent the wheel’ to find solutions to issues already solved by other members of the community. 2. Here, we introduce palaeoverse, a community-driven R package to aid data preparation and exploration for quantitative palaeobiological research. The package is freely available and has three core principles: (1) streamline data preparation and analyses; (2) enhance code readability; and (3) improve reproducibility of results. To develop these aims, we assessed the analytical needs of the broader palaeobiological community using an online survey, in addition to incorporating our own experiences. 3. In this work, we first report the findings of the survey, which shaped the development of the package. Subsequently, we describe and demonstrate the functionality available in palaeoverse and provide usage examples. Finally, we discuss the resources we have made available for the community and our future plans for the broader Palaeoverse project. 4. palaeoverse is a community-driven R package for palaeobiology, developed with the intention of bringing palaeobiologists together to establish agreed standards for high-quality quantitative research. The package provides a user-friendly platform for preparing data for analysis with well-documented open-source code to enhance transparency. The functionality available in palaeoverse improves code reproducibility and accessibility, which is beneficial for both the review process and future research

Highly efficient PCR assay to discriminate allelic DNA methylation status using whole genome amplification

<p>Abstract</p> <p>Background</p> <p>We previously developed a simple method termed <it>Hpa</it>II-<it>McrBC </it>PCR (HM-PCR) to discriminate allelic methylation status of the genomic sites of interest, and successfully applied it to a comprehensive analysis of CpG islands (CGIs) on human chromosome 21q. However, HM-PCR requires 200 ng of genomic DNA to examine one target site, thereby precluding its application to such samples that are limited in quantity.</p> <p>Findings</p> <p>We developed <it>Hpa</it>II-<it>McrBC </it>whole-genome-amplification PCR (HM-WGA-PCR) that uses whole-genome-amplified DNA as the template. HM-WGA-PCR uses only 1/100th the genomic template material required for HM-PCR. Indeed, we successfully analyzed 147 CGIs by HM-WGA-PCR using only ~300 ng of DNA, whereas previous HM-PCR study had required ~30 μg. Furthermore, we confirmed that allelic methylation status revealed by HM-WGA-PCR is identical to that by HM-PCR in every case of the 147 CGIs tested, proving high consistency between the two methods.</p> <p>Conclusions</p> <p>HM-WGA-PCR would serve as a reliable alternative to HM-PCR in the analysis of allelic methylation status when the quantity of DNA available is limited.</p