5 research outputs found
HANS CHRISTIAN ANDERSEN – TOLD FOR CHILDREN
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja I.
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben Michael
- Burgdorf Kristoffer S.
- Buring Julie E.
- Böger Carsten A.
- Bønnelykke Klaus
- Børglum Anders D.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Croteau-Chonka Damien
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P. V.
- Dedoussis George V.
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I.
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmståhl Sölve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P.
- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Janaka de Silva de
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L.
- Köttgen Anna
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian’an
- Lubitz Steven A.
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A.
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I.
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellström Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T.
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher Sivert
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- O’Donnell Christopher J.
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Partida Gabriel Cuellar
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte V.
- Peyser Patricia A.
- Pitkänen Niina
- Polašek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits Richard
- Rotter Jerome I.
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderick C.
- Smit Roelof A. J.
- Smith Albert V.
- Smith J. Gustav
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan
- Sun Yan V.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A.
- Theusch Elizabeth
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Vollenweider Peter
- Vonk Judith M.
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik K S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John Anker Henrik
- Åsvold Bjørn Olav
- ‘t Hart Leen M.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja I.
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben Michael
- Burgdorf Kristoffer S.
- Buring Julie E.
- Böger Carsten A.
- Bønnelykke Klaus
- Børglum Anders D.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen
- Chanock Stephen J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Croteau-Chonka Damien
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P. V.
- Dedoussis George V.
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I.
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmståhl Sölve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry I.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P.
- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Janaka de Silva de
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L.
- Köttgen Anna
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian’an
- Lubitz Steven A.
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A.
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I.
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellström Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T.
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher Sivert
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- O’Donnell Christopher J.
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Partida Gabriel Cuellar
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte V.
- Peyser Patricia A.
- Pitkänen Niina
- Polašek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits Richard
- Rotter Jerome I.
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderick C.
- Smit Roelof A. J.
- Smith Albert V.
- Smith J. Gustav
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan
- Sun Yan V.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A.
- Theusch Elizabeth
- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Vollenweider Peter
- Vonk Judith M.
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik K S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John Anker Henrik
- Åsvold Bjørn Olav
- ‘t Hart Leen M.
- Publication venue
- 'The Nature Conservancy'
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10–20% (14–24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
A saturated map of common genetic variants associated with human height.
- Author
- 't Hart Leen M
- 23andMe Research Team
- Abecasis Goncalo R
- Adair Linda S
- Adams Hieab HH
- Aguilar-Salinas Carlos A
- Ahluwalia Tarunveer S
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A
- Alvarez Marcus
- Andersen Mette K
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D
- Arnett Donna K
- Asselbergs Folkert W
- Assimes Themistocles L
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A
- Bergler Tobias
- Berndt Sonja I
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F
- Biino Ginevra
- Bin Wei Wen
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Bollepalli Sailalitha
- Bonnycastle Lori L
- Boomsma Dorret I
- Borja Judith B
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W
- Bradfield Jonathan P
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S
- Brody Jennifer A
- Brumpton Ben
- Burgdorf Kristoffer S
- Buring Julie E
- Böger Carsten A
- Bønnelykke Klaus
- Børglum Anders D
- Cade Brian E
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Catamo Eulalia
- Caulfield Mark J
- Cañadas-Garre Marisa
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C
- Chandak Giriraj R
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen J
- Chasman Daniel I
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W
- Collins Francis S
- Concas Maria Pina
- Cooper Richard S
- Couture Christian
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L Adrienne
- Cutler Michael J
- Damrauer Scott M
- Danning Rebecca
- Dantoft Thomas M
- Daw E Warwick
- de Borst Gert J
- de Groot Lisette CPGM
- De Jager Philip L
- de Kleijn Dominique PV
- Dedoussis George V
- Degenhard Frauke
- Delgado Graciela E
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke I
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- DiscovEHR (DiscovEHR and MyCode Community Health Initiative)
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F
- Ekici Arif B
- Elders Petra JM
- Eliasen Anders U
- Eliassen A Heather
- Ellinor Patrick T
- Elmståhl Sölve
- eMERGE (Electronic Medical Records and Genomics Network)
- Engmann Jorgen E
- Erdmann Jeanette
- Esko Tõnu
- Evans Michele K
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D
- Feenstra Bjarke
- Feitosa Mary F
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W
- Frayling Timothy M
- Freedman Barry I
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P
- Goddard Michael E
- Goel Anuj
- Golightly Yvonne M
- Gonzalez-Villalpando Clicerio
- Gordon Scott D
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E
- Grallert Harald
- Grant Struan FA
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas F
- Hansen Torben
- Hartman Catharina A
- Hattersley Andrew T
- Havulinna Aki S
- Haworth Simon J
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R
- Heid Iris M
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W
- Highland Heather H
- Hindy George
- Hirschhorn Joel N
- Hishigaki Haretsugu
- Ho Yuk-Lam A
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E
- Hottenga Jouke-Jan
- Hoyng Carel B
- Huang Hongyan
- Huang Jie
- Huang Paul L
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E
- Hung Yi-Jen
- Hunt Steven C
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hyppönen Elina
- Iacono William G
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D
- Ikram M Arfan
- Isasi Carmen R
- Isono Masato
- Jackson Anne U
- Jackson Rebecca D
- Janaka de Silva H
- Jansen Iris E
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Johansson Ingegerd
- Jonas Jost B
- Jonsson Anna
- Joshi Peter K
- Jousilahti Pekka
- Jukema J Wouter
- Justice Anne E
- Jäger Susanne
- Jöckel Karl-Heinz
- Jørgensen Torben
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon LR
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L
- Kentistou Katherine A
- Kessler Thorsten
- Khera Amit V
- Khor Chiea Chuen
- Kiemeney Lambertus ALM
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E
- Knol Maria J
- Koh Woon-Puay
- Koistinen Heikki A
- Kolovou Genovefa D
- Kooner Jaspal S
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kähönen Mika
- Kårhus Line L
- Köttgen Anna
- Laakso Markku
- Lange Leslie A
- Langenberg Claudia
- Launer Lenore J
- Lauzon Marie
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R
- Lehtimäki Terho
- Leonard Hampton L
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lifelines Cohort Study
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth JF
- Lores-Motta Laura
- Luan Jian'an
- Lubitz Steven A
- Lye Stephen J
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Lüll Kreete
- Machado Moara
- Mackey David A
- Magnusson Patrik KE
- Mahajan Anubha
- Malden Deborah E
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark I
- McDaid Aaron F
- McGarrah Robert W
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E
- Meidtner Karina
- Melendez Tori L
- Mellström Dan
- Mercader Josep M
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E
- Millwood Iona Y
- Mishra Pashupati P
- Mitchell Braxton D
- Mitchell Paul
- Mitchell Ruth E
- Mohlke Karen L
- Mook-Kanamori Dennis O
- Moore Amy
- Morgan Anna
- Morris Andrew D
- Mucci Lorelei A
- Mucha Soeren
- Mukamel Ronen E
- Munroe Patricia B
- Munz Matthias
- Mägi Reedik
- März Winfried
- Møllehave Line T
- Nakatochi Masahiro
- Nalls Mike A
- Nazarian Saman
- Nelson Amanda E
- Nelson Christopher P
- Nethander Maria
- Neville Matt J
- Newton-Cheh Christopher
- Ng Maggie CY
- Nho Chu Won
- Nielsen Aneta A
- Nielsen Christopher S
- Nolte Ilja M
- Nongmaithem Suraj S
- Noordam Raymond
- North Kari E
- Ntalla Ioanna
- Nutile Teresa
- Nöthen Markus M
- O'Donnell Christopher J
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J
- Orozco Lorena
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin NA
- Pandit Anita
- Parra Esteban J
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E
- Penninx Brenda WJH
- Perusse Louis
- Peters Annette
- Petersen Eva RB
- Petersen Liselotte V
- Peyser Patricia A
- Pitkänen Niina
- Polašek Ozren
- Porteous David J
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- PRACTICAL Consortium
- Pramstaller Peter P
- Preuss Michael H
- Province Michael A
- Pyarajan Saiju
- Pärna Katri
- Qi Qibin
- Qu Jia
- Rader Daniel J
- Raffield Laura M
- Raghavan Sridharan
- Raitakari Olli T
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S
- Ramirez Julia
- Rao Dabeeru C
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W
- Redline Susan
- Reilly Dermot F
- Reiner Alexander P
- Rhee Sang Youl
- Ridker Paul M
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M
- Rohde Rebecca
- Rosendaal Frits R
- Rotter Jerome I
- Rudan Igor
- Ruggiero Daniela
- Ruotsalainen Sanni E
- Rutters Femke
- Ryan Kathleen A
- Rüeger Sina
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J
- Sanghera Dharambir K
- Sattar Naveed
- Saxena Richa
- Schmidt Börge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B
- Schunkert Heribert
- Scott Laura J
- Scott Rodney J
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J
- Shoemaker M Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B
- Sinner Moritz F
- Sitlani Colleen M
- Slieker Roderick C
- Smit Roelof AJ
- Smith Albert V
- Smith J Gustav
- Smith Jennifer A
- Smyth Laura J
- Snieder Harold
- Southam Lorraine
- Spector Tim D
- Spracklen Cassandra N
- Stampfer Meir J
- Stark Klaus J
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P
- Sun Liang
- Sun Yan V
- Tabara Yasuharu
- Tai E Shyong
- Takeuchi Fumihiko
- Tallapragada Divya Sri Priyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D
- Tayo Bamidele O
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
- Teumer Alexander
- Thanaraj Thangavel A
- Theusch Elizabeth
- Thompson Deborah J
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul RHJ
- Timpson Nicholas J
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusié-Luna Maria-Teresa
- Tönjes Anke
- Uitterlinden Andre G
- Understanding Society Scientific Group
- VA Million Veteran Program
- Vaccargiu Simona
- van Dam Rob M
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J
- Van der Velde Nathalie
- van Duijn Cornelia M
- van Klinken Jan B
- van Schoor Natasja M
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M
- Vitart Veronique
- Vollenweider Peter
- Vrieze Scott
- Völker Uwe
- Völzke Henry
- Wacher-Rodarte Niels H
- Walker Mark
- Walters Robin G
- Wang Carol A
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J
- Warren Helen R
- Watanabe Richard M
- Watkins Hugh
- Weir David R
- Werge Thomas M
- Wickremasinghe Ananda R
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L
- Wilkens Lynne R
- Willemsen Gonneke
- Willer Cristen J
- Willett Walter C
- Wilson James F
- Winkler Thomas W
- Winsvold Bendik S
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R
- Wright Alan F
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loïc
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L
- Yousri Noha A
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E
- Zmuda Joseph M
- Zoledziewska Magdalena
- Zonderman Alan B
- Zwart John-Anker
- Åsvold Bjørn Olav
- Publication venue
- Nature
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
A saturated map of common genetic variants associated with human height
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Adams Hieab H. H.
- Aguilar-Salinas Carlos A.
- Ahluwalia Tarunveer S.
- Akiyama Masato
- Al-Mulla Fahd
- Allison Matthew A.
- Alvarez Marcus
- Andersen Mette K.
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Asvold Bjorn Olav
- Attia John
- Auton Adam
- Banas Bernhard
- Bandinelli Stefania
- Bartell Eric
- Bennett David A.
- Bergler Tobias
- Berndt Sonja, I
- Bharadwaj Dwaipayan
- Bhaskar Seema
- Bielak Lawrence F.
- Biino Ginevra
- Bisgaard Hans
- Boehnke Michael
- Boerwinkle Eric
- Boger Carsten A.
- Bollepalli Sailalitha
- Bonnelykke Klaus
- Bonnycastle Lori L.
- Boomsma Dorret, I
- Borglum Anders D.
- Borja Judith B.
- Bork-Jensen Jette
- Bouchard Claude
- Bowden Donald W.
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brumpton Ben
- Burgdorf Kristoffer S.
- Buring Julie E.
- Cade Brian E.
- Cai Hui
- Cai Qiuyin
- Campbell Archie
- Canadas-Garre Marisa
- Catamo Eulalia
- Caulfield Mark J.
- Chai Jin-Fang
- Chai Xiaoran
- Chambers John C.
- Chandak Giriraj R.
- Chang Li-Ching
- Chang Yi-Cheng
- Chanock Stephen J.
- Chasman Daniel, I
- Chaturvedi Nish
- Chen Chien-Hsiun
- Chen Shyh-Huei
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chesi Alessandra
- Cho Yoon Shin
- Choi Seung Hoan
- Christofidou Paraskevi
- Christophersen Ingrid E.
- Chung Ren-Hua
- Ciullo Marina
- Cocca Massimiliano
- Cole John W.
- Collins Francis S.
- Concas Maria Pina
- Cooper Richard S.
- Couture Christian
- Cruz Miguel
- Cucca Francesco
- Cuellar-Partida Gabriel
- Cupples L. Adrienne
- Cutler Michael J.
- Damrauer Scott M.
- Danning Rebecca
- Dantoft Thomas M.
- Daw E. Warwick
- de Borst Gert J.
- de Groot Lisette C. P. G. M.
- De Jager Philip L.
- de Kleijn Dominique P., V
- de Silva H. Janaka
- Dedoussis George, V
- Degenhard Frauke
- Delgado Graciela E.
- Delitala Alessandro
- Deloukas Panos
- Demirkan Ayse
- den Hollander Anneke, I
- Deng Xuan
- Devineni Poornima
- Dietl Alexander
- Dimitriou Maria
- Dimitrov Latchezar
- Dorajoo Rajkumar
- Du Shufa
- Easton Douglas F.
- Ekici Arif B.
- Elders Petra J. M.
- Eliasen Anders U.
- Eliassen A. Heather
- Ellinor Patrick T.
- Elmstahl Solve
- Engmann Jorgen E.
- Erdmann Jeanette
- Esko Tonu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Farmaki Aliki-Eleni
- Fatkin Diane
- Faul Jessica D.
- Feenstra Bjarke
- Feitosa Mary F.
- Fernandez-Lopez Juan-Carlos
- Ferreira Teresa
- Ferrucci Luigi
- Ford Ian
- Forer Lukas
- Fornage Myriam
- Francescatto Margherita
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freedman Barry, I
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Yan
- Gao Zishan
- Gasparini Paolo
- Geller Frank
- Giannakopoulou Olga
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Gjesing Anette P.
- Goddard Michael E.
- Goel Anuj
- Golightly Yvonne M.
- Gonzalez-Villalpando Clicerio
- Gordon Scott D.
- Gordon-Larsen Penny
- Gorski Mathias
- Graff Marielisa
- Graham Sarah E.
- Grallert Harald
- Grant Struan F. A.
- Grarup Niels
- Griffiths Lyn
- Grove Jakob
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Haiman Christopher
- Hakonarson Hakon
- Hansen Thomas F.
- Hansen Torben
- Hartman Catharina A.
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon J.
- Hayward Caroline
- He Jing
- Heard-Costa Nancy
- Hebbar Prashantha
- Heckbert Susan R.
- Heid Iris M.
- Heng Chew-Kiat
- Hengstenberg Christian
- Hewitt Alex W.
- Highland Heather H.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam A.
- Hofer Edith
- Holliday Elizabeth
- Horn Katrin
- Hornsby Whitney E.
- Hottenga Jouke-Jan
- Hoyng Carel B.
- Huang Hongyan
- Huang Jie
- Huang Paul L.
- Huang Wei
- Huerta-Chagoya Alicia
- Huffman Jennifer E.
- Hung Yi-Jen
- Hunt Steven C.
- Huo Shaofeng
- Hveem Kristian
- Hwang Mi Yeong
- Hypponen Elina
- Iacono William G.
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Isasi Carmen R.
- Isono Masato
- Jackson Anne U.
- Jackson Rebecca D.
- Jager Susanne
- Jansen Iris E.
- Jarvelin Marjo-Riitta
- Ji Yingjie
- Jiang Yunxuan
- Jin Zi-Bing
- Jockel Karl-Heinz
- Johansson Ingegerd
- Jonas Jost B.
- Jonsson Anna
- Jorgensen Torben
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Justice Anne E.
- Kahonen Mika
- Kalafati Ioanna-Panagiota
- Kamatani Yoichiro
- Kanai Masahiro
- Kang Kui Dong
- Kanoni Stavroula
- Kaprio Jaakko
- Karaderi Tugce
- Kardia Sharon L. R.
- Karhus Line L.
- Karpe Fredrik
- Kasturiratne Anuradhani
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kember Rachel L.
- Kentistou Katherine A.
- Kessler Thorsten
- Khera Amit, V
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kirchhof Paulus
- Kivimaki Mika
- Kleber Marcus E.
- Knol Maria J.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolovou Genovefa D.
- Kooner Jaspal S.
- Kooperberg Charles
- Kottgen Anna
- Kovacs Peter
- Kraaijeveld Adriaan
- Kraft Peter
- Krauss Ronald M.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Laakso Markku
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Lauzon Marie
- Le Marchand Loic
- Le Phuong
- Lea Rodney
- Lee Hyejin
- Lee Jong-Young
- Lee Nanette R.
- Lehtimaki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Huaixing
- Li Liming
- Li Shengchao A.
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Honghuang
- Lin Kuang
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Xueping
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Loh Po-Ru
- London Barry
- Long Jirong
- Loos Ruth J. F.
- Lores-Motta Laura
- Luan Jian'an
- Lubitz Steven A.
- Lull Kreete
- Lye Stephen J.
- Lyssenko Valeriya
- Lyytikainen Leo-Pekka
- Machado Moara
- Mackey David A.
- Magi Reedik
- Magnusson Patrik K. E.
- Mahajan Anubha
- Malden Deborah E.
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marcus Gregory M.
- Marouli Eirini
- Marten Jonathan
- Martin Nicholas G.
- Marz Winfried
- Matsuda Fumihiko
- Mattheisen Manuel
- Mavarani Laven
- McCarthy Mark, I
- McDaid Aaron F.
- McGarrah Robert W.
- McGue Matt
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Medland Sarah E.
- Meidtner Karina
- Melendez Tori L.
- Mellstrom Dan
- Mercader Josep M.
- Metspalu Andres
- Miao Jenkai
- Milaneschi Yuri
- Miller Jason E.
- Millwood Iona Y.
- Mishra Pashupati P.
- Mitchell Braxton D.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mollehave Line T.
- Mook-Kanamori Dennis O.
- Moore Amy
- Morgan Anna
- Morris Andrew D.
- Mucci Lorelei A.
- Mucha Soeren
- Mukamel Ronen E.
- Munroe Patricia B.
- Munz Matthias
- Nakatochi Masahiro
- Nalls Mike A.
- Nazarian Saman
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newton-Cheh Christopher
- Ng Maggie C. Y.
- Nho Chu Won
- Nielsen Aneta A.
- Nielsen Christopher S.
- Nolte Ilja M.
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Nothen Markus M.
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J.
- Ohlsson Claes
- Okada Yukinori
- Oldehinkel Albertine J.
- Orozco Lorena
- Pahkala Katja
- Pajukanta Paivi
- Palmer Colin N. A.
- Pandit Anita
- Parna Katri
- Parra Esteban J.
- Pattaro Cristian
- Pauper Marc
- Pedersen Oluf
- Pennell Craig E.
- Penninx Brenda W. J. H.
- Perusse Louis
- Peters Annette
- Petersen Eva R. B.
- Petersen Liselotte, V
- Peyser Patricia A.
- Pitkanen Niina
- Polasek Ozren
- Porteous David J.
- Posthuma Danielle
- Poveda Alaitz
- Power Chris
- Pramstaller Peter P.
- Preuss Michael H.
- Province Michael A.
- Pyarajan Saiju
- Qi Qibin
- Qu Jia
- Rader Daniel J.
- Raffield Laura M.
- Raghavan Sridharan
- Raitakari Olli T.
- Rakugi Hiromi
- Ralhan Sarju
- Rallidis Loukianos S.
- Ramirez Julia
- Rao Dabeeru C.
- Rasheed Asif
- Raven Dennis
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Rienstra Michiel
- Ripatti Samuli
- Ritchie Marylyn D.
- Rivadeneira Fernando
- Riveros Carlos
- Roden Dan M.
- Rohde Rebecca
- Rosendaal Frits R.
- Rotter Jerome, I
- Rudan Igor
- Rueger Sina
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rutters Femke
- Ryan Kathleen A.
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sanghera Dharambir K.
- Sattar Naveed
- Saxena Richa
- Schmidt Borge
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Laura J.
- Scott Rodney J.
- Sendamarai Anoop
- Sever Peter
- Shen Botong
- Shi Jingchunzi
- Shin Jae Hun
- Shiroma Eric J.
- Shoemaker M. Benjamin
- Shu Xiao-Ou
- Sidore Carlo
- Sidorenko Julia
- Sim Xueling
- Simonsick Eleanor M.
- Sims Mario
- Singh Jai Rup
- Singleton Andrew B.
- Sinner Moritz F.
- Sitlani Colleen M.
- Slieker Roderic K. C.
- Smit Roelof A. J.
- Smith Albert, V
- Smith J. Gustav
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- Smyth Laura J.
- Snieder Harold
- Southam Lorrain E.
- Spector Tim D.
- Spracklen Cassandra N.
- Stampfer Meir J.
- Stark Klaus J.
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Strachan David P.
- Sun Liang
- Sun Yan, V
- t' Hart Leen M.
- Tabara Yasuharu
- Tai E. Shyong
- Takeuchi Fumihiko
- Tallapragada Divyasripriyanka
- Tang Hua
- Tardif Jean-Claude
- Taylor Kent D.
- Tayo Bamidele O.
- Tcheandjieu Catherine
- Terzikhan Natalie
- Tesolin Paola
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- Thompson Deborah J.
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tonjes Anke
- Tremblay Angelo
- Trompet Stella
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turman Constance
- Tusie-Luna Maria-Teresa
- Uitterlinden Andre G.
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- Van der Velde Nathalie
- van Duijn Cornelia M.
- van Klinken Jan B.
- van Schoor Natasja M.
- van Setten Jessica
- Vedantam Sailaja
- Verma Shefali S.
- Verweij Niek
- Veturi Yogasudha
- Vidal Pedro Marques
- Visscher Peter M.
- Vitart Veronique
- Volker Uwe
- Vollenweider Peter
- Volzke Henry
- Vrieze Scott
- Wacher-Rodarte Niels H.
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Lihua
- Wang Ya Xing
- Wang Zhe
- Wareham Nicholas J.
- Warren Helen R.
- Watanabe Richard M.
- Watkins Hugh
- Wei Wen Bin
- Weir David R.
- Werge Thomas M.
- Wickremasinghe Ananda R.
- Widen Elisabeth
- Wielscher Matthias
- Wiggins Kerri L.
- Wilkens Lynne R.
- Willemsen Gonneke
- Willer Cristen J.
- Willett Walter C.
- Wilson James F.
- Winkler Thomas W.
- Winsvold Bendik S.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wright Alan F.
- Wu Jer-Yuarn
- Wu Yang
- Wuttke Matthias
- Xia Rui
- Xie Tian
- Xu Huichun
- Yajnik Chittaranjan S.
- Yamamoto Ken
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yengo Loic
- Yin Xianyong
- Yokota Mitsuhiro
- Young Hannah
- Young Kristin L.
- Yousri Noha A.
- Yu Lei
- Yuan Jian-Min
- Zeggini Eleftheria
- Zemel Babette S.
- Zeng Lingyao
- Zhang Weihua
- Zhang Xinyuan
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiaofeng
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zoledziewska Magdalena
- Zonderman Alan B.
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study