Частота стоматологічних захворювань у дітей

Изучена обращаемость детей за специализированной помощью в стоматологический центр медицинской академии. Установлено, что наиболее часто дети обращаются за специализированной медицинской помощью в связи с поражением твердых тканей зубов, околозубных тканей и слизистой оболочки полости рта. Значительно реже – по поводу других стоматологических заболеваний. Такая специфика структуры патологии органов ротовой полости требует нацеленных лечебно – профилактических и организационных мероприятий. There was studied the incidence of children visiting dental center of medical academy in need of medical aid. It was determined that most often children call for medical aid due to damages of hard tooth tissues, periodontium and mucous membrane of mouth cavity. More rarely they call for aid due to other dental diseases. Such specific character of structure of mouth cavity pathology requires specialized medical – preventive and organizational measures

Deesign and synthesis of novel inhibitors of inositol monophosphatase, potential drug candidates in the treatment of bipolar disorder

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Bis-Benzyl Protected 6-Amino Cyclitols are Poisenous to Pd/C Catalysed Hydrogenolysis of Benzyl Ethers

Pd/C and Pd(OH)2/C catalysts are both poisoned by bis-benzyl protected 6-aminocyclitols thereby inhibiting the hydrogenolysis of benzyl ethers but removing N-Cbz groups chemoselectively. This outcome was unaltered by the use of different hydrogen donors. Replacement of the C-6 nitrogen atom by oxygen resulted in the starting materials being fully deprotected under similar conditions. These findings add cyclitolamines to the list of amines/bases that are poisonous to Pd/C catalysts during hydrogenolysis. Pd/C and Pd(OH)2/C catalysts are both poisoned by bis-benzyl protected 6-aminocyclitols thereby inhibiting the hydrogenolysis of benzyl ethers but removing N-Cbz groups chemoselectively

Technetium-binding in labelled HYNIC-peptide conjugates: Role of coordinating amino acids

Electrospray mass spectrometry (ESMS) of certain peptides labelled with 99mTc via hydrazinonicotinamide (HYNIC) with tricine as co-ligand shows one Tc-bound tricine, whereas typically two are observed. We speculated that this was due to coordination of a neighbouring histidine (His) or glutamate (Glu). To investigate this possibility, several short peptides incorporating lysine (HYNIC), with and without His and Glu at different positions in the sequence, were radiolabelled with 99mTc, using tricine, ethylenediaminediacetic acid (EDDA) and nicotinic acid as co-ligands. The products were examined by HPLC-ESMS, cysteine challenge and bovine serum albumin (BSA) challenge. Peptides with His nearby on either side of lysine (HYNIC) contained only one tricine and showed markedly enhanced structural homogeneity and stability to cysteine challenge and BSA binding, except those with His located at the N-terminus. Peptides without His, or with neighbouring N-terminal His, contained two tricines and were less stable to cysteine challenge and BSA binding. Glu participated in Tc-binding but did not enhance stability. We conclude that neighbouring His or Glu side chains coordinate to Tc and this could alter peptide or protein conformation. Inclusion of His in a neighbouring position to lysine (HYNIC) enhances stability, improves homogeneity and reduces the demand of the metal center for binding to additional co-ligands. © 2009 Elsevier Inc. All rights reserved

Trifluoroacetyl as a protecting group for HYNIC: stability in the presence of electrophiles and application in the synthesis of 99mTc-radiolabelled peptides

TrifluoroacetylHYNIC-peptides have recently been shown to label directly with 99mTc as efficiently as their non-trifluoroacetylated analogs. In this work, the trifluoroacetyl (Tfa) moiety has been evaluated as a protecting group for HYNIC against reaction with strong electrophiles. Fmoc-(trifluoroacetylHYNIC)-lysine, the chosen model starting material, was found to be resistant against acetaldehyde and benzylchloroformate challenges, at 1 mol equiv and a 1000 M excess, respectively. In contrast, the Fmoc-(HYNIC)-lysine derivative, with a free hydrazine group, was quantitatively converted to the corresponding hydrazone after a 1 h incubation with acetaldehyde. Fmoc-(trifluoroacetylHYNIC)-lysine was also found to be stable over a wide pH range (3.6-10) to the acetaldehyde challenge. High efficiency 99mTc-radiolabelling (99%) was achieved in the presence of acetaldehyde using Fmoc-(trifluoroacetylHYNIC)-lysine, as compared to a poor radiolabelling yield (34%) obtained with the non-trifluoroacetylated analog. These findings firmly establish the trifluoroacetyl group as a convenient and effective protecting group for HYNIC, and as a promising alternative to currently available labelling strategies. © 2010 Elsevier Ltd. All rights reserved

Product-like inhibitors of inositol monophosphatase

A series of product-like inhibitors of inositol monophosphatase have been prepared and tested for activity in vitro as possible leads for treatment of bipolar disorders. Compounds possessing a 6-alkyloxy side chain were inhibitors but less efficacious than those possessing a 6-aminoalkyl side chain. These new structures show promise as inhibitors possessing the bioavailability and characteristics necessary for drug development. A series of product-like inhibitors of inositol monophosphatase have been prepared and tested for activity in vitro as possible leads for treatment of bipolar disorders. Compounds possessing a 6-alkyloxy side chain were inhibitors but less efficacious than those possessing a 6-aminoalkyl side chain. These new structures show promise as inhibitors possessing the bioavailability and characteristics necessary for drug development