Design and Optimization of Mefenamic acid Fast Dissolving Tablets Employing Modified Starch by 23 Factorial Design

Latest developments in the technology have promoted viable dosage alternatives through oral route for pediatrics, bed ridden, and nauseous patients. Patient preference is one of the most important aspects in pharmacy practice. Now a day’s pharmacy companies are coming up with innovative drug delivery systems to deliver the drugs efficiently and with less side effects. This innovation led to the introduction of the concept of fast dissolving tablets. Though, a wide range of superdisintegrant is available for formulation of fast dissolving tablets. Still there is continuous need of development of superdisintegrants. Therefore in the present investigation, starch based superdisintegrant was prepared and evaluated for its application in the design of fast dissolving dosage forms. Keywords: Fast Dissolving Tablets, Superdisintegrant, Modified Starch, Mefenamic acid

Design, Optimization and Evaluation of Piroxicam Fast Dissolving Tablets Employing Modified Starch by 23 Factorial Design.

Fast dissolving tablet have potential advantages over conventional dosage forms, which has helped patient compliance, convenience, bioavailability and rapid onset of action. These are very good for drug delivery over geriatric and pediatric patients. They have significant advantages of solid and liquid dosage forms, because when they are in solid form and when transformed into liquid form and within few seconds after it is consumed. With new technologies for it formulation many commercial products are available in the market for the patients. So FDT have awful scope for being the delivery system. Therefore in the present investigation, starch based superdisintegrant was prepared and evaluated for its application in the design of fast dissolving dosage forms of piroxicam. Keywords: Fast Dissolving Tablets, Superdisintegrant, Modified Starch, Piroxicam

Expression, purification, crystallization and preliminary X-ray diffraction analysis of conjugated bile salt hydrolase from Bifidobacterium longum

Conjugated bile salt hydrolase (BSH) catalyses the hydrolysis of the amide bond that conjugates bile acids to glycine and to taurine. The BSH enzyme from Bifidobacterium longum was overexpressed in Escherichia coli BL21(DE3), purified and crystallized. Crystallization conditions were screened using the hanging-drop vapour-diffusion method. Crystal growth, with two distinct morphologies, was optimal in experiments carried out at 303 K. The crystals belong to the hexagonal system, space group P622 with unit-cell parameters a = b = 124.86, c = 219.03 Angstrom, and the trigonal space group P321, with unit-cell parameters a = b = 125.24, c = 117.03 Angstrom. The crystals diffracted X-rays to 2.5 Angstrom spacing. Structure determination using the multiple isomorphous replacement method is in progress

Expression, purification, crystallization and preliminary X-ray diffraction analysis of conjugated bile salt hydrolase from Bifidobacterium longum

Conjugated bile salt hydrolase (BSH) catalyses the hydrolysis of the amide bond that conjugates bile acids to glycine and to taurine. The BSH enzyme from Bifidobacterium longum was overexpressed in Escherichia coli BL21(DE3), purified and crystallized. Crystallization conditions were screened using the hanging-drop vapour-diffusion method. Crystal growth, with two distinct morphologies, was optimal in experiments carried out at 303 K. The crystals belong to the hexagonal system, space group P622 with unit-cell parameters a = b = 124.86, c = 219.03 Angstrom, and the trigonal space group P321, with unit-cell parameters a = b = 125.24, c = 117.03 Angstrom. The crystals diffracted X-rays to 2.5 Angstrom spacing. Structure determination using the multiple isomorphous replacement method is in progress

Application of green concepts in the libraries of Thiruvananthapuram: an investigation

The present study aims to judge the green concepts in the library buildings of Thiruvananthapuram by the key areas listed by Leadership in Energy and Environmental Design(LEED) such as site location, water conservation, energy efficiency, materials, indoor air quality, and a bonus category for innovation and design. The data for the study was collected from the chief librarian and the users of the major libraries in Thiruvananthapuram such as Kerala University Library (KUL), State Central Library (SCL), Kerala Legislature Library (KLL), Regional Cancer Centre Library (RCCL), VSSC library (VSSCL) and Centre for Development Studies Library (CDSL). The study analyzed the methods and techniques adopted for greening libraries. The data collected from 259 users of the libraries under study through stratified random sampling. A five point Likert scale was used for identifying the attitude of the users towards greening concepts. It was found that Vikram Sarabhai Space Centre (VSSC) Library occupied the top position followed by Kerala University Library in the adoption of greening concepts and methods. The users of State Central library and Kerala Legislature library have positive attitude towards the introduction of green concepts in their libraries

Heat capacity and magnetocaloric effect in polycrystalline Gd1-xSmxMn2Si2

We report the magnetocaloric effect in terms of isothermal magnetic entropy change as well as adiabatic temperature change, calculated using the heat capacity data. Using the zero field heat capacity data, the magnetic contribution to the heat capacity has been estimated. The variations in the magnetocaloric behavior have been explained on the basis of the magnetic structure of these compounds. The refrigerant capacities have also been calculated for these compounds

Multiple magnetic transitions and magnetocaloric effect in Gd1-xSmxMn2Ge2 compounds

Magnetic and magnetocaloric properties of polycrystalline samples of Gd1-xSmxMn2Ge2 have been studied. All the compounds except GdMn2Ge2 show re-entrant ferromagnetic behavior. Multiple magnetic transitions observed in these compounds are explained on the basis of the temperature dependences of the exchange strengths of the rare earth and Mn sublattices. Magnetocaloric effect is found to be positive at the re-entrant ferromagnetic transition, whereas it is negative at the antiferro-ferromagnetic transition. In SmMn2Ge2, the magnetic entropy change associated with the re-entrant transition is found to decrease with field, which is attributed to the admixture effect of the crystal field levels. The isothermal magnetic entropy change is found to decrease with increase in Sm concentration.Comment:

Food Supply and Security

India's total food grain production in 1950-1951 was low at 50.8 million tonnes, with a population of 361 million. Thus, the food grain production in 1950-1951 was 140.7 kg per person per annum or 0.39 kg per day. Thanks to Indian farmers and agricultural scientists who worked hard to increase the food grain production through new crop varieties and production technologies, along with the supportive policies of the governments that paved the way for the Green Revolution in Indian Agriculture. Achievements of the green revolution further led to achievements in other agricultural and allied sectors like the white revolution with substantial gains from milk production, followed by the yellow revolution with a significant increase in edible oilseed production, and the pink revolution with an increase in meat and poultry production to a significant extent. This chapter mainly discusses where does India stand today in terms of its agriculture when compared to its independence in 1947? As the data for 1947 for most of the indicators is not available, 1951 is considered the base year and compared the various indicators for the year 2021