The flow chart of three intervention models.

<p>A total of 1,815 subjects participated in the preliminary survey that is part of a larger study on MC in China. Of these, 1,670 agreed to participate in this intervention study and were cluster-randomized by their work site to one of three intervention models. The standard model consisted a one-time on-site session, in which participants received special printed and audio-visual materials and participated in expert- and volunteer-led discussions. The two-stage model delivered special printed and audio-visual materials at 0 month, followed by expert- and volunteer-led discussions after at ~1 month interval. The three-stage model delivered general printed and audio-visual materials at 0 month, special printed and audio-visual materials at ~1 month, and expert- and volunteer-led discussions at ~2 months. Participants’ knowledge of MC, willingness to accept MC, number of MC surgeries undertaken, cost per uptake, and HIV/STIs infections were surveyed at 6-month and 9-month follow-up visits. Within each model, participants who did not receive a particular stage of interventions were considered lost to follow up and were discontinued from all next intervention stages. Only data with complete intervention and questionnaire records were eligible for analysis.</p

Reasons for refusing PrEP or participating in a clinical trial.

<p>Reasons for refusing PrEP or participating in a clinical trial.</p

HIV Pre-Exposure Prophylaxis Interest among Female Sex Workers in Guangxi, China

<div><p>Objectives</p><p>Acceptability of pre-exposure prophylaxis (PrEP) and willingness to participate in a clinical trial for both safety and efficacy of PrEP were investigated among female sex workers (FSWs) in Guangxi, China.</p><p>Methods</p><p>A cross-sectional study was performed in three cities in Guangxi. Structured, self-administered questionnaires were used to assess the acceptability of PrEP and the willingness to participate in a clinical trial. Multivariable logistic regression models were fitted to identify predictors.</p><p>Results</p><p>Among 405 participants, 15.1% had heard of PrEP. If PrEP was deemed to be effective, safe and provided for free, 85.9% reported that they would accept it, and 54.3% of those who accepted PrEP said that they would participate in a clinical trial. The increased acceptability of PrEP was associated with working in male dominated venues, higher income, a poor family relationship, better HIV/AIDS knowledge, not realizing HIV risk from unfamiliar clients, not being forced to use condoms by the gatekeepers, consistent use of condoms, and use of drugs to prevent STD infection. The increased willingness to participate in a clinical trial was associated with a poor family relationship, better HIV/AIDS knowledge, not realizing HIV risk from unfamiliar clients, a willingness to adhere to daily PreP use, and not being concerned about discrimination by others. The main reason for rejecting PrEP or participating in a clinical trial was the concern about the side effects of PrEP.</p><p>Conclusions</p><p>Acceptability of PrEP among Guangxi FSWs is relatively high, indicating that PrEP intervention programs may be feasible for Chinese FSWs. Given the fact that most of the participants had never heard of PrEP before, and that family, gatekeepers, and social discrimination could significantly affect its acceptability, a comprehensive mix of multiple interventions is necessary for the successful implementation of a PrEP program among this population in Guangxi.</p></div

Logistic regression analysis of intention to participate in a clinical trial.

<p>Logistic regression analysis of intention to participate in a clinical trial.</p

Willingness to accept PrEP or participate in a clinical trial (N, %).

<p>Willingness to accept PrEP or participate in a clinical trial (N, %).</p

Demographic characteristics of participants.

<p>Demographic characteristics of participants.</p