SYNTHESIS OF PHENYL 1H-INDAZOLO [1,2-b] PHTHALAZINE TRIONE DERIVATIVES WITH THEIR BIOLOGICAL EVALUATION

Heterocyclic compounds are the most global moieties in chemical compounds which exhibit wide spectrum of pharmacological activities. Multicomponent reactions are important tool in the hands of organic chemist’s,researcher. Since they offer improved atom economy for construction of complex molecules over the stepwise liner convergent synthesis. A simple, efficient and green protocol has been developed for the synthesis phenyl 1H-Indazolo [1,2-b] Phthalazine trione derivatives from a one pot four componant condensation of Phthalic anhydride, Hydrazine hydrate, Dimedone and different substituted aromatic aldehydes was refluxed independently in ethanol using Cesium Chloride as an efficient catalyst. Synthesized compounds were screened for their Antioxidant activity. These newly synthesized compounds were evaluated by their spectral analysis. Keywords: MCRs, Phthalic anhydride, Hydrazine hydrate, Dimedone, Aromatic aldehyd