西准噶尔紫苏花岗岩成因岩石学研究

Charnockites occur as giant enclaves or pendants(?) in the Miaoergou Batholith, Western Junggar region. These rocks are composed of ortho- and clinopyroxenes, fayalite, perthite, antiperthite, and quartz, and are characterized by positive εNd values (+4.8+5.9). Mineral assemblage, texture and field occurrence indicate an igneous origin for the charnockites.Temperature and pressure estimations give700800 ℃and 45 kb crystallization conditions.The charnockites enclose small surmicaceous enclaves and large banded angular xenoliths. The former are considered as restites, while the latter are equivalent to the country pyroclastic rocks. The positive but lowerεNd values (+2.6+3.5) for the restites require that the juvenile lower crust was the dominant source for charnockitic magma, and parental magma of the charnockites from this source was mixed with some melt from depleted mantle, before crystallization. The voluminous alkaline granites in the region were probably from the same magma source, but crystallized at upper crust depth.紫苏花岗岩呈岩体形式侵入于石炭纪地层中,又为碱长花岗岩侵入.紫苏花岗岩由斜方辉石、单斜辉石、铁橄榄石、条纹长石、石英组成,以正εNd 为特征(εNd=+4.8~+5.8).矿物组成、结构和野外产状表明:这些紫苏花岗岩是火成成因的.温压计算估测其结晶条件是T=700~800 ℃, P=420~575 kPa.紫苏花岗岩中有小的富云母包体和巨大的条带状捕虏体.前者被认为是残留体,后者与其围岩-火山碎屑岩相当.残留体中较低的εNd 正值(εNd=+2.6~+3.5)要求新生的下部地壳是紫苏花岗岩的主要源岩:来自这些源岩的紫苏花岗岩的母岩浆在结晶前与一些来自于亏损地幔中的融体混合.该地区体积巨大的碱性花岗岩可能也来自相同的岩浆源,只不过它是在较浅的地壳深度上结晶的.关键词:新疆;西准噶尔;紫苏花岗岩;富云母包体;碱性花岗岩紫苏花岗岩呈岩体形式侵入于石炭纪地层中,又为碱长花岗岩侵入.紫苏花岗岩由斜方辉石、单斜辉石、铁橄榄石、条纹长石、石英组成,以正εNd 为特征(εNd=+4.8~+5.8).矿物组成、结构和野外产状表明:这些紫苏花岗岩是火成成因的.温压计算估测其结晶条件是T=700~800 ℃, P=420~575 kPa.紫苏花岗岩中有小的富云母包体和巨大的条带状捕虏体.前者被认为是残留体,后者与其围岩-火山碎屑岩相当.残留体中较低的εNd 正值(εNd=+2.6~+3.5)要求新生的下部地壳是紫苏花岗岩的主要源岩:来自这些源岩的紫苏花岗岩的母岩浆在结晶前与一些来自于亏损地幔中的融体混合.该地区体积巨大的碱性花岗岩可能也来自相同的岩浆源,只不过它是在较浅的地壳深度上结晶的.published_or_final_versio

Various Sizes of Sliding Event Bursts in the Plastic Flow of Metallic Glasses Based on a Spatiotemporal Dynamic Model

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Bacterial persisters are a stochastically formed subpopulation of low-energy cells.

Persisters represent a small subpopulation of non- or slow-growing bacterial cells that are tolerant to killing by antibiotics. Despite their prominent role in the recalcitrance of chronic infections to antibiotic therapy, the mechanism of their formation has remained elusive. We show that sorted cells of Escherichia coli with low levels of energy-generating enzymes are better able to survive antibiotic killing. Using microfluidics time-lapse microscopy and a fluorescent reporter for in vivo ATP measurements, we find that a subpopulation of cells with a low level of ATP survives killing by ampicillin. We propose that these low ATP cells are formed stochastically as a result of fluctuations in the abundance of energy-generating components. These findings point to a general "low energy" mechanism of persister formation

Blood Pressure and Hypertension in Adults Permanently Living at High Altitude: A Systematic Review and Meta-Analysis.

Aryal, Nirmal, Mark Weatherall, Yadav Kumar Deo Bhatta, and Stewart Mann. Blood pressure and hypertension in adults permanently living at high altitude: a systematic review and meta-analysis. High Alt Med Biol. 17:185-193, 2016.-The objective of this study was to estimate the associations between altitude and mean blood pressure (BP) (or prevalence of hypertension [HT]) in adults who live permanently at high altitude. A literature search was conducted in December 2014 using PubMed, Scopus, and OvidSP (MedLine and EMBASE) databases to identify relevant observational studies. Inclusion criteria were reports of studies in populations permanently living at an altitude of ≥2400 m and in those 18 years or older. Meta-regression was used to estimate the association between average BP and HT and altitude. We identified 3375 articles and inclusion criteria were met for 21 reports, which included a total of 40,854 participants. Random-effects meta-regression estimated that for every 1000 m elevation the average systolic BP (SBP) (95% confidence interval [CI]) increased by 17 mmHg (0.2 to 33.8), p = 0.05 and diastolic BP (DBP) by 9.5 mmHg (0.6 to 18.4), p = 0.04 in participants with Tibetan origin. By contrast, in participants with non-Tibetan origin, average SBP decreased by 5.9 mmHg (-19.1 to 7.3), p = 0.38 and DBP by 4 mmHg (-13 to 5), p = 0.38. The odds ratios (95% CI) for the proportion of participants with HT per 1000 m increment in the altitude were 2.01 (0.37 to 11.02), p = 0.446 and 4.05 (0.07 to 244.69), p = 0.489 for Tibetan and non-Tibetan participants, respectively. Sensitivity analysis excluding two studies with older participants (≥60 years) reversed the direction of this effect in non-Tibetans with odds ratio (95% CI) of 0.10 (0.004 to 2.22) per 1000 m, p = 0.143. Overall, this review suggests weak association between BP and altitude in Tibetan origin populations

Anisotropic Radial Layout for Visualizing Centrality and Structure in Graphs

This paper presents a novel method for layout of undirected graphs, where nodes (vertices) are constrained to lie on a set of nested, simple, closed curves. Such a layout is useful to simultaneously display the structural centrality and vertex distance information for graphs in many domains, including social networks. Closed curves are a more general constraint than the previously proposed circles, and afford our method more flexibility to preserve vertex relationships compared to existing radial layout methods. The proposed approach modifies the multidimensional scaling (MDS) stress to include the estimation of a vertex depth or centrality field as well as a term that penalizes discord between structural centrality of vertices and their alignment with this carefully estimated field. We also propose a visualization strategy for the proposed layout and demonstrate its effectiveness using three social network datasets.Comment: Appears in the Proceedings of the 25th International Symposium on Graph Drawing and Network Visualization (GD 2017

Topological orbital ladders

We unveil a topological phase of interacting fermions on a two-leg ladder of unequal parity orbitals, derived from the experimentally realized double-well lattices by dimension reduction. $Z_2$ topological invariant originates simply from the staggered phases of $sp$-orbital quantum tunneling, requiring none of the previously known mechanisms such as spin-orbit coupling or artificial gauge field. Another unique feature is that upon crossing over to two dimensions with coupled ladders, the edge modes from each ladder form a parity-protected flat band at zero energy, opening the route to strongly correlated states controlled by interactions. Experimental signatures are found in density correlations and phase transitions to trivial band and Mott insulators.Comment: 12 pages, 5 figures, Revised title, abstract, and the discussion on Majorana numbe

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implicated in the cell death that underlies several degenerative conditions2, and induction of ferroptosis by the inhibition of GPX4 has emerged as a therapeutic strategy to trigger cancer cell death5. However, sensitivity to GPX4 inhibitors varies greatly across cancer cell lines6, which suggests that additional factors govern resistance to ferroptosis. Here, using a synthetic lethal CRISPR-Cas9 screen, we identify ferroptosis suppressor protein 1 (FSP1) (previously known as apoptosis-inducing factor mitochondrial 2 (AIFM2)) as a potent ferroptosis-resistance factor. Our data indicate that myristoylation recruits FSP1 to the plasma membrane where it functions as an oxidoreductase that reduces coenzyme Q10 (CoQ) (also known as ubiquinone-10), which acts as a lipophilic radical-trapping antioxidant that halts the propagation of lipid peroxides. We further find that FSP1 expression positively correlates with ferroptosis resistance across hundreds of cancer cell lines, and that FSP1 mediates resistance to ferroptosis in lung cancer cells in culture and in mouse tumour xenografts. Thus, our data identify FSP1 as a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. These findings define a ferroptosis suppression pathway and indicate that pharmacological inhibition of FSP1 may provide an effective strategy to sensitize cancer cells to ferroptosis-inducing chemotherapeutic agents

Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A population-based analysis

Objectives: Early surgical resection remains the recommended treatment option for most small renal mass (≤4 cm). We examined the long-term overall survival (OS) of patients managed with delayed and immediate nephrectomy of cT1a renal cancer. / Patient and methods: We utilized the National Cancer Database (2005–2010) to identify 14,677 patients (immediate nephrectomy: 14,050 patients vs. late nephrectomy: 627 patients) aged 180 days from diagnosis, respectively. Inverse probability of treatment weighting–adjusted Kaplan-Meier curves and Cox proportional hazards regression analyses were used to compare OS of patients in the 2 treatment arms. Influence of patient age and Charlson Comorbidity Index on treatment effect was tested by interactions. Sensitivity analysis was performed to explore the outcome of delaying nephrectomy for >12 months. / Results: Median patient age was 55 years with a median follow-up of 82.5 months. Inverse probability of treatment weighting-adjusted Kaplan-Meier curves suggest no significant difference between treatment arms (immediate nephrectomy [180 days]) (Hazard ratio 0.96; 95% confidence interval 0.73–1.26; P = 0.77). This outcome was consistent between all patients regardless of age (P = 0.48). Sensitivity analysis reports no difference in OS even if nephrectomy was delayed by >12 months (P = 0.60). / Conclusions: We report that delayed and immediate nephrectomy for cT1a renal cell carcinoma confers comparable long-term OS. These findings suggest that a period of observation of between 6 and 12 months is safe to allow identification of renal masses, which will benefit from surgical resection

Nanomechanical Detection of Itinerant Electron Spin Flip

Spin is an intrinsically quantum property, characterized by angular momentum. A change in the spin state is equivalent to a change in the angular momentum or mechanical torque. This spin-induced torque has been invoked as the intrinsic mechanism in experiments ranging from the measurements of angular momentum of photons g-factor of metals and magnetic resonance to the magnetization reversal in magnetic multi-layers A spin-polarized current introduced into a nonmagnetic nanowire produces a torque associated with the itinerant electron spin flip. Here, we report direct measurement of this mechanical torque and itinerant electron spin polarization in an integrated nanoscale torsion oscillator, which could yield new information on the itinerancy of the d-band electrons. The unprecedented torque sensitivity of 10^{-22} N m/ \sqrt{Hz} may enable applications for spintronics, precision measurements of CP-violating forces, untwisting of DNA and torque generating molecules.Comment: 14 pages, 4 figures. visit http://nano.bu.edu/ for related paper

Graphene Photonics and Optoelectronics

The richness of optical and electronic properties of graphene attracts enormous interest. Graphene has high mobility and optical transparency, in addition to flexibility, robustness and environmental stability. So far, the main focus has been on fundamental physics and electronic devices. However, we believe its true potential to be in photonics and optoelectronics, where the combination of its unique optical and electronic properties can be fully exploited, even in the absence of a bandgap, and the linear dispersion of the Dirac electrons enables ultra-wide-band tunability. The rise of graphene in photonics and optoelectronics is shown by several recent results, ranging from solar cells and light emitting devices, to touch screens, photodetectors and ultrafast lasers. Here we review the state of the art in this emerging field.Comment: Review Nature Photonics, in pres