The critical detection distance for passively tracking tagged fish using a fixed radio telemetry station in a small stream

Background: Fixed radio telemetry stations are used to study the movement ecology of fishes in streams and rivers. A common assumption of such studies is that detection efficiency remains constant through space and time. The objective of this study was to understand how site characteristics and tag distance can influence the detection efficiency of a fixed receiver when used for fisheries research in a small stream. Field tests included a fixed receiver station on Forty Mile Creek, in Banff National Park, AB, Canada that recorded signals from radio tags over specified distances (i.e., 0 m, 27 m, 53 m, 80 m) within the expected detection range from July to October, 2016. Model selection was used to test which parameters may influence detection efficiency. Results: The fixed receiver was able to record an average of 89% of transmissions over the study period. Detection efficiency was greater or equal to 0.97 at tag di

Application of inverse modeling to geothermal reservoir simulation

The authors have developed inverse modeling capabilities for the non-isothermal, multiphase, multicomponent numerical simulator TOUGH2 to facilitate automatic history matching and parameter estimation based on data obtained during testing and exploitation of geothermal fields.The ITOUGH2 code allows one to estimate TOUGH2 input parameters based on any type of observation for which a corresponding simulation output can be calculated. Furthermore, a detailed residual and error analysis is performed, and the uncertainty of model predictions can be evaluated. Automatic history matching using ITOUGH2 is robust and efficient so that model parameters affecting geothermal field performance can reliably be estimated based on a variety of field measurements such as pressures, temperatures, flow rates, and enthalpies. The paper describes the methodology of inverse modeling and provides a detailed discussion of sample problems to demonstrate the application of the method to data from geothermal reservoirs

RiceWrist Robotic Device for Upper Limb Training: Feasibility Study and Case Report of Two Tetraplegic Persons with Spinal Cord Injury

Regaining upper extremity function is the primary concern of persons with tetraplegia caused by spinal cord injury (SCI). Robotic rehabilitation has been inadequately tested and underutilized in rehabilitation of the upper extremity in the SCI population. Given the acceptance of robotic training in stroke rehabilitation and SCI gait training, coupled with recent evidence that the spinal cord, like the brain, demonstrates plasticity that can be enhanced by repetitive movement training such as that available with robotic devices, it is probable that robotic upper extremity training of persons with SCI could be clinically beneficial. The primary goal of this pilot study was to test the feasibility of using a novel robotic device –the RiceWrist Exoskeleton- for rehabilitation of the upper limbs (UL) of two tetraplegic persons with incomplete SCI. Two pilot experiments were conducted. Experiment 1was the first novel attempt to administer treatment with the RiceWrist. The left UL of a tetraplegic subject was treated during seven therapy sessions. The subject’s feedback and the investigator’s obser-vations were used to enhance the robotic device and the corresponding graphical-interface. In Experiment 2, a second tetra-plegic subject underwent 10 three-hour training sessions administered by a physical therapist. Smoothness factor (FS) –a new measure developed in Experiment 1- was used as the primary outcome to test the subject’s performance before and after the training. The RiceWrist was modified according to the feedback obtained in Experiment 1. Thereafter, the device was suc-cessfully administered for upper limb training of the tetraplegic individual. Noticeable improvements in FS were observed for the stronger arm of the subject who completed 10 sessions of training. Improvements were also observed in the subject’s hand according to the Jebsen-Taylor Hand Function Test. Results from this study suggest a potential application of the RiceWrist for rehabilitation of SCI individuals and offer valuable information regarding development of UL robotic devices for this population

The Gain Reduction Method for manual tracking of radio-tagged fish in streams

Background: Manual tracking has been used since the 1970s as an effective radio telemetry approach for evaluating habitat use of fish in fluvial systems. Radio tags are often located by continually reducing the gain when approaching the tag along a watercourse to estimate its location, termed here as the 'Gain Reduction Method'. However, to our knowledge the accuracy of this method has not been empirically evaluated and reported in the literature. Here, the longitudinal and lateral positional errors of radio tags are assessed when applying the Gain Reduction Method in a small stream environment. Longitudinal and lateral positional errors (i.e. the difference between the e

Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience.

BACKGROUND: Uveal melanoma exhibits a high incidence of metastases; and, to date, there is no systemic therapy that clearly improves outcomes. The anticytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody ipilimumab is a standard of care for metastatic melanoma; however, the clinical activity of CTLA-4 inhibition in patients with metastatic uveal melanoma is poorly defined. METHODS: To assess ipilimumab in this setting, the authors performed a multicenter, retrospective analysis of 4 hospitals in the United States and Europe. Clinical characteristics, toxicities, and radiographic disease burden, as determined by central, blinded radiology review, were evaluated. RESULTS: Thirty-nine patients with uveal melanoma were identified, including 34 patients who received 3 mg/kg ipilimumab and 5 who received 10 mg/kg ipilimumab. Immune-related response criteria and modified World Health Organization criteria were used to assess the response rate (RR) and the combined response plus stable disease (SD) rate after 12 weeks, after 23 weeks, and overall (median follow-up, 50.4 weeks [12.6 months]). At week 12, the RR was 2.6%, and the response plus SD rate was 46.%; at week 23, the RR was 2.6%, and the response plus SD rate was 28.2%. There was 1 complete response and 1 late partial response (at 100 weeks after initial SD) for an immune-related RR of 5.1%. Immune-related adverse events were observed in 28 patients (71.8%) and included 7 (17.9%) grade 3 and 4 events. Immune-related adverse events were more frequent in patients who received 10 mg/kg ipilimumab than in those who received 3 mg/kg ipilimumab. The median overall survival from the first dose of ipilimumab was 9.6 months (95% confidence interval, 6.3-13.4 months; range, 1.6-41.6 months). Performance status, lactate dehydrogenase level, and an absolute lymphocyte count ≥ 1000 cells/μL at week 7 were associated significantly with survival. CONCLUSIONS: In this multicenter, retrospective analysis of 4 hospitals in the United States and Europe of patients with uveal melanoma, durable responses to ipilimumab and manageable toxicity were observed

TFOS DEWS II Report Executive Summary

This article presents an Executive Summary of the conclusions and recommendations of the 10-chapter TFOS DEWS II report. The entire TFOS DEWS II report was published in the July 2017 issue of The Ocular Surface. A downloadable version of the document and additional material, including videos of diagnostic and management techniques, are available on the TFOS website: www.TearFilm.org

Expansions of algebras and superalgebras and some applications

After reviewing the three well-known methods to obtain Lie algebras and superalgebras from given ones, namely, contractions, deformations and extensions, we describe a fourth method recently introduced, the expansion of Lie (super)algebras. Expanded (super)algebras have, in general, larger dimensions than the original algebra, but also include the Inonu-Wigner and generalized IW contractions as a particular case. As an example of a physical application of expansions, we discuss the relation between the possible underlying gauge symmetry of eleven-dimensional supergravity and the superalgebra osp(1|32).Comment: Invited lecture delivered at the 'Deformations and Contractions in Mathematics and Physics Workshop', 15-21 January 2006, Mathematisches Forschungsinstitut Oberwolfach, German

Monte Carlo Methods for Estimating Interfacial Free Energies and Line Tensions

Excess contributions to the free energy due to interfaces occur for many problems encountered in the statistical physics of condensed matter when coexistence between different phases is possible (e.g. wetting phenomena, nucleation, crystal growth, etc.). This article reviews two methods to estimate both interfacial free energies and line tensions by Monte Carlo simulations of simple models, (e.g. the Ising model, a symmetrical binary Lennard-Jones fluid exhibiting a miscibility gap, and a simple Lennard-Jones fluid). One method is based on thermodynamic integration. This method is useful to study flat and inclined interfaces for Ising lattices, allowing also the estimation of line tensions of three-phase contact lines, when the interfaces meet walls (where "surface fields" may act). A generalization to off-lattice systems is described as well. The second method is based on the sampling of the order parameter distribution of the system throughout the two-phase coexistence region of the model. Both the interface free energies of flat interfaces and of (spherical or cylindrical) droplets (or bubbles) can be estimated, including also systems with walls, where sphere-cap shaped wall-attached droplets occur. The curvature-dependence of the interfacial free energy is discussed, and estimates for the line tensions are compared to results from the thermodynamic integration method. Basic limitations of all these methods are critically discussed, and an outlook on other approaches is given

MOA-cam3: a wide-field mosaic CCD camera for a gravitational microlensing survey in New Zealand

We have developed a wide-field mosaic CCD camera, MOA-cam3, mounted at the prime focus of the Microlensing Observations in Astrophysics (MOA) 1.8-m telescope. The camera consists of ten E2V CCD4482 chips, each having 2kx4k pixels, and covers a 2.2 deg^2 field of view with a single exposure. The optical system is well optimized to realize uniform image quality over this wide field. The chips are constantly cooled by a cryocooler at -80C, at which temperature dark current noise is negligible for a typical 1-3 minute exposure. The CCD output charge is converted to a 16-bit digital signal by the GenIII system (Astronomical Research Cameras Inc.) and readout is within 25 seconds. Readout noise of 2--3 ADU (rms) is also negligible. We prepared a wide-band red filter for an effective microlensing survey and also Bessell V, I filters for standard astronomical studies. Microlensing studies have entered into a new era, which requires more statistics, and more rapid alerts to catch exotic light curves. Our new system is a powerful tool to realize both these requirements.Comment: Experimental Astronomy in pres

Proximity effect at superconducting Sn-Bi2Se3 interface

We have investigated the conductance spectra of Sn-Bi2Se3 interface junctions down to 250 mK and in different magnetic fields. A number of conductance anomalies were observed below the superconducting transition temperature of Sn, including a small gap different from that of Sn, and a zero-bias conductance peak growing up at lower temperatures. We discussed the possible origins of the smaller gap and the zero-bias conductance peak. These phenomena support that a proximity-effect-induced chiral superconducting phase is formed at the interface between the superconducting Sn and the strong spin-orbit coupling material Bi2Se3.Comment: 7 pages, 8 figure