ON THE EFFECTIVENESS OF PANTING STRINGERS AND WEB FRAMES OF A SHIP: (2nd Report)

Introduction. / Assumptions and Procedures of Analysis. / Analysis for the Structure with Symmetrically Arranged Stringers in Longitudinal Direction. / Coeffiicents in Slope Deflection Equations for Stringers. / Analysis under Separate Treatment of the moment of Inertia of Upper and Lower Stringer. / Equation of Stringers at any Sapan. / Coefficients of Flexure for Web Frames. / Elastic Equations of Stringers for Two Consecutive Spans (a - 1, a) and (a, a+ 1). / End Condition. / Analysis for the Structure with Actual Arrangement of Stringers and Web Frames. / Couclusions and Acknowledgement

EXPERIMENTAL STUDIES ON THE ROLLING EFFECT ON HEAT LOSSES FROM OIL TANKER CARGOES

1. Introduction. / 2. Preliminary Experiment / 3. Tank Model Experiments / 4. Analysis of Data of Test Ship 5. ConclusionExperimental studies were carried out on the rolling effect upon heat transfer through the shell plating of an oil tanker. The results obtained are as follows: (1) Increment in the heat transfer coefficient for the shell plating by rolling of ship was investigated using a 1/50 size model and the following empirical formulae were obtained. For side shell plating: Nu = 0.0160 Re^＜0.942＞Pr^^1/3 For bottom shell plating: Nu≅ 0.0155 Re^＜0.910＞Pr^^1/3 (2) The experimental results obtained by the test on an actual ship are reasonably and well explained using the empirical formulae mentioned above. (3) Increment in heat transfer by rolling of ship is mainly caused by the stirring effect of stiffeners

Mechanistic Involvement of the Calpain-Calpastatin System in Alzheimer Neuropathology

The mechanism by which amyloid-β peptide (Aβ) accumulation causes neurodegeneration in Alzheimer\u27s disease (AD) remains unresolved. Given that Aβ perturbs calcium homeostasis in neurons, we investigated the possible involvement of calpain, a calcium-activated neutral protease. We first demonstrated close postsynaptic association of calpain activation with Aβ plaque formation in brains from both patients with AD and transgenic (Tg) mice overexpressing amyloid precursor protein (APP). Using a viral vector-based tracer, we then showed that axonal termini were dynamically misdirected to calpain activation-positive Aβ plaques. Consistently, cerebrospinal fluid from patients with AD contained a higher level of calpain-cleaved spectrin than that of controls. Genetic deficiency of calpastatin (CS), a calpain-specific inhibitor protein, augmented Aβ amyloidosis, tau phosphorylation, microgliosis, and somatodendritic dystrophy, and increased mortality in APP-Tg mice. In contrast, brain-specific CS overexpression had the opposite effect. These findings implicate that calpain activation plays a pivotal role in the Aβ-triggered pathological cascade, highlighting a target for pharmacological intervention in the treatment of AD

三瀬所長還歴記念論文集（要報）

Universal Solution of Framed Structures.[MISE, Kozaburo] / On the Decay of Torsional Vibration of a Wire-and-Rotator.[SENDA, Kanae] / On the Tables for the Calculation of the Coefficient of Diffusion from the Surface Concentration.[MATANO, Chujiro] / On a Problem of Bending a Steel Beam by Three Rollers.[NEGORO, Shosaburo] / On the Propagation of Spherical Wave of Finite Amplitude.[KUNII, Shujiro] / Stresses in an Orthogonal Aeolotropic Infinite Plate with an Elliptic Hole under Uniform Tension.[HIGUCHI, Masakazu] / On the Slope-Deflection Formulae in Vector Forms for the Three Dimensional Structures.[SUHARA, Jiro] / On the Hardness of the Superlattice Phase in the Mg-Cd System.[SATO, Takao] / On the Approximate Computation of the Critical Load.[NAKAGAWA , Hajime] / On the Mechanism of Disruption.[FUTAGAMI, Tetsugoro