Global logistics indicators, supply chain metrics, and bilateral trade patterns

Past research into the determinants of international trade highlighted the importance of the basic spatial gravity model augmented by additional variables representing sources of friction. Studies modeled many sources of friction using various proxies, including indices based on expert judgment in some cases. This paper focuses on logistics friction and draws on a data set recently compiled by the World Bank with specific quantitative metrics of logistics performance interms of time, cost, and variability in time. It finds that the new variables that relate directly to logistics performance have a statistically significant relationship with the level of bilateral trade. It also finds that a single logistics index can capture virtually all of the explanatory power of multiple logistics indicators. The findings should spur public and private agencies that have direct or indirect power over logistics performance to focus attention on reducing sources of friction so as to improve their country's ability to compete in today's global economy. Moreover, since the logistics metrics are directly related to operational performance, countries can use these metrics to target actions to improve logistics and monitor their progress.Common Carriers Industry,Transport and Trade Logistics,Economic Theory&Research,Free Trade,Trade Policy

Family planning methods among women in a vaginal microbicide feasibility study in rural KwaZulu-Natal, South Africa

This study investigated contraceptive use among women in rural KwaZulu-Natal, South Africa. Of 866 sexually active women not intending pregnancy and screened for a microbicide feasibility study, 466 (54%) reported currently using modern contraceptives: injectables (31%), condoms (12%), sterilization (60%) and pills (4%). Multivariable logistic regression analyses revealed statistically significantly higher odds of current contraceptive use among married vs. engaged/unmarried women (aOR 1.64), multiparous vs. nulliparous (aOR 4.45) and women who completed secondary education or above vs. primary or less (aOR 1.64). Significantly lower odds of use were observed among women aged 40+ vs. age 15-19 (aOR 0.38). Age, marital status, education level and parity were associated with different contraceptive method choices. Among 195 women followed longitudinally for 9 months, contraceptive use increased significantly from 56% to 70%, largely due to increased condom use (15% to 28%). Results highlight the importance of integrating family planning and HIV/STI prevention counseling and informing promotion of further contraceptive uptake among women not intending pregnancy

Reasons for female neonaticide in India

Invited commentary on ‘Neonaticide in India and the stigma of female gender: report of two cases’, Mishra et al

Cooperative Cleaning for Distributed Autonomous Robot Systems Using Fuzzy Cognitive Maps

Cooperative Autonomous Cleaning is a simple challenge that can be implemented with the help of Fuzzy Cognitive Maps (FCM) by simulating the actual thinking process of the human. The human mind organizes its thoughts in priorities and this feature could be exploited well if a priori knowledge of the system exists. This technique has been attempted here for a DARS

A Unified treatment of small and large- scale dynamos in helical turbulence

Helical turbulence is thought to provide the key to the generation of large-scale magnetic fields. Turbulence also generically leads to rapidly growing small-scale magnetic fields correlated on the turbulence scales. These two processes are usually studied separately. We give here a unified treatment of both processes, in the case of random fields, incorporating also a simple model non-linear drift. In the process we uncover an interesting plausible saturated state of the small-scale dynamo and a novel analogy between quantum mechanical (QM) tunneling and the generation of large scale fields. The steady state problem of the combined small/large scale dynamo, is mapped to a zero-energy, QM potential problem; but a potential which, for non-zero mean helicity, allows tunneling of bound states. A field generated by the small-scale dynamo, can 'tunnel' to produce large-scale correlations, which in steady state, correspond to a force-free 'mean' field.Comment: 4 pages, 1 figure, Physical Review Letters, in pres

Modulation of Host Defense Peptide-Mediated Human Mast Cell Activation by LPS

Human β-defensin3 (hBD3) and the cathelicidin LL-37 are host defense peptides (HDPs) that directly kill microbes and display immunomodulatory/wound-healing properties via the activation of chemokine, formylpeptide and epidermal growth factor receptors on leukocytes and epithelial cells. A C-terminal 14 amino acid hBD3 peptide with all Cys residues replaced with Ser (CHRG01) and an LL-37 peptide consisting of residues 17-29 (FK-13) display antimicrobial activity but lack immunomodulatory property. Surprisingly, we found that CHRG01 and FK-13 caused Ca2+ mobilization and degranulation in human mast cells via a novel G protein-coupled receptor known as Mas-related gene-X2 (MrgX2). At local sites of bacterial infection, the negatively charged LPS likely interacts with cationic HDPs to inhibit their activity and thus providing a mechanism for pathogens to escape host defense mechanisms. We found that LPS caused almost complete inhibition of hBD3 and LL-37-induced Ca2+ mobilization and mast cell degranulation. In contrast, it had no effect on CHRG01 and FK-13-induced mast cell responses. These findings suggest that HDP derivatives that kill microbes, harness mast cell\u27s host defense and wound-healing properties via the activation of MrgX2 but are resistant to inhibition by LPS could be utilized for the treatment of antibiotic-resistant microbial infections. © The Author(s) 2015

Roles of Mas-Related G Protein–Coupled Receptor X2 on Mast Cell–Mediated Host Defense, Pseudoallergic Drug Reactions, and Chronic Inflammatory Diseases

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage, contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However, MCs are best known for their roles in allergic and inflammatory diseases, such as anaphylaxis, food allergy, rhinitis, itch, urticaria, atopic dermatitis, and asthma. In addition to the highaffinity IgE receptor (FcεRI), MCs express numerous G protein–coupled receptors (GPCRs), which are the largest group of membrane receptor proteins and the most common targets of drug therapy. Antimicrobial host defense peptides, neuropeptides, major basic protein, eosinophil peroxidase, and many US Food and Drug Administration–approved peptidergic drugs activate human MCs through a novel GPCR known as Mas-related G protein–coupled receptor X2 (MRGPRX2; formerly known as MrgX2). Unique features of MRGPRX2 that distinguish it from other GPCRs include their presence both on the plasma membrane and intracellular sites and their selective expression in MCs. In this article we review the possible roles of MRGPRX2 on host defense, drug-induced anaphylactoid reactions, neurogenic inflammation, pain, itch, and chronic inflammatory diseases, such as urticaria and asthma. We propose that host defense peptides that kill microbes directly and activate MCs through MRGPRX2 could serve as novel GPCR targets to modulate host defense against microbial infection. Furthermore, mAbs or small-molecule inhibitors of MRGPRX2 could be developed for the treatment of MCdependent allergic and inflammatory disorders. (J Allergy Clin Immunol 2016;138:700-10.