IS Per Capita Real GDP Stationary in China¡H Evidence Based on A Panel SURADF Approach

In this study we use newly developed Panel SURADF tests of the Breuer et al., (2001) to investigate the time-series properties of 25 Chinese provinces¡¦ per capita real GDP for the 1952-1998 period. While the other Panel-based unit root tests are joint tests of a unit root for all members of the panel and are incapable of determining the mix of I(0) and I(1) series in the panel setting, the Panel SURADF tests a separate unit-root null hypothesis for each individual panel member and, therefore identifies how many and which series in the panel are stationary processes. The empirical results indicate that for all the provinces studied per capita real GDP are non-stationary, except Hebei, Jeilongjiang, Qinghai and Shaanxi when Breuer et al.¡¦s (2001) Panel SURADF tests are conducted.Per Capita Real GDP Panel Unit Root Tests

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway.

SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson's disease (PD). Our previous study demonstrates that SIRT3 had a neuroprotective effect on a rotenone-induced PD cell model, however, the exact mechanism is unknown. In this study, we investigated the underlying mechanism. We established a SIRT3 stable overexpression cell line using lentivirus infection in SH-SY5Y cells. Then, a PD cell model was established using rotenone. Our data demonstrate that overexpression of SIRT3 increased the level of the autophagy markers LC3 II and Beclin 1. After addition of the autophagy inhibitor 3-MA, the protective effect of SIRT3 diminished: the cell viability decreased, while the apoptosis rate increased; α-synuclein accumulation enhanced; ROS production increased; antioxidants levels, including SOD and GSH, decreased; and MMP collapsed. These results reveal that SIRT3 has neuroprotective effects on a PD cell model by up-regulating autophagy. Furthermore, SIRT3 overexpression also promoted LKB1 phosphorylation, followed by activation of AMPK and decreased phosphorylation of mTOR. These results suggest that the LKB1-AMPK-mTOR pathway has a role in induction of autophagy. Together, our findings indicate a novel mechanism by which SIRT3 protects a rotenone-induced PD cell model through the regulation of autophagy, which, in part, is mediated by activation of the LKB1-AMPK-mTOR pathway

An experimental study of VEGF induced changes in vasoactivity in pig retinal arterioles and the influence of an anti-VEGF agent

BACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in ocular physiology. Anti-VEGF agents are now used for treatment of common retinal diseases. This study characterises the vasoactive properties of VEGF in isolated perfused pig retinal arterioles under normal tone or endothelin-1 (ET-1) pre-contracted conditions and determines the influence of an anti VEGF agent on VEGF induced vasoactivity. METHODS: An isolated perfused retinal arteriole preparation was used. The outer diameter of retinal vessels was monitored at 2 second intervals in response to VEGF and the anti VEGF agent, bevacizumab. The effect of intraluminal delivery of VEGF was determined over a wide concentration range (10(-16) to 10(-7) M) both with and without pre-contraction with ET-1 (3 x 10(-9) M). Bevacizumab (0.35 mg mL(-1)) was applied extraluminally to determine the influence of bevacizumab on VEGF induced vasoactive changes on ET-1 pre-contracted vessels. RESULTS: In retinal arterioles with normal tone, VEGF induced a concentration dependent contraction at low concentrations, reaching 93.5% at 10(-11) M and then contraction was reduced at higher concentrations, recovering to 98.1% at 10(-7) M. VEGF produced a potent concentration dependent vasodilatation in arterioles pre-contracted with ET-1. VEGF induced vasodilatation in arterioles pre-contracted with ET-1 was significantly inhibited by bevacizumab. CONCLUSIONS: VEGF induced vasoactive changes in pig retinal arterioles are dependent on concentration and vascular tone. Bevacizumab inhibits VEGF-induced vasodilatation in pre-contracted arterioles

Pelizaeus-Merzbacher Disease, Easily Misdiagnosed as Cerebral Palsy: A Report of a Three-generation Family

Pelizaeus-Merzbacher disease (PMD) is an X-linked recessive disorder affecting myelination of the central nervous system, and is caused by mutations of the proteolipid protein 1 (PLP1) gene. Clinical manifestations of PMD are variable and major features include progressive nystagmus, spasticity, tremor, ataxia, and psychomotor delay. We describe a classical PMD patient who had been misdiagnosed as cerebral palsy. He had nystagmus and psychomotor delay since infancy and tremor with ataxia developing gradually. Brain MRI revealed demyelination over white matter of the cerebral hemispheres and posterior limbs of the internal capsules. Positive family history led to subsequent mutation analysis, which identified a novel mutation (c.88G>C) in PLP1 in the proband, as well as his affected brother and maternal uncle, and asymptomatic maternal grandmother, mother and two sisters. Therefore, PMD should be considered in a cerebral palsy-like patient with or without positive family history. Mutation analysis is crucial for early diagnosis and further genetic counseling

Computational ghost imaging with hybrid transforms by integrating Hadamard, discrete cosine, and Haar matrices

A scenario of ghost imaging with hybrid transform approach is proposed by integrating Hadamard, discrete cosine, and Haar matrices. The measurement matrix is formed by the Kronecker product of the two different transform matrices. The image information can be conveniently reconstructed by the corresponding inverse matrices. In experiment, six hybridization sets are performed in computational ghost imaging. For an object of staggered stripes, only one bucket signal survives in the Hadamard-cosine, Haar-Hadamard, and Haar-cosine hybridization sets, demonstrating flexible image compression. For a handmade windmill object, the quality factors of the reconstructed images vary with the hybridization sets. Sub-Nyquist sampling can be applied to either or both of the different transform matrices in each hybridization set in experiment. The hybridization method can be extended to apply more transforms at once. Ghost imaging with hybrid transforms may find flexible applications in image processing, such as image compression and image encryption.Comment: 5 pages, 4 figure

Second-trimester Maternal Serum Quadruple Test for Down Syndrome Screening: A Taiwanese Population-based Study

SummaryObjectiveTo assess the usefulness of quadruple test screening for Down syndrome in Taiwan.Materials and MethodsMaternal serum concentrations of a-fetoprotein, human chorionic gonadotropin, unconjugated estriol, and inhibin A were measured in 21,481 pregnant women from 15 to 20 weeks of gestation.ResultsOf the 21,481 women, 977 returned values greater than the high-risk cut-off value (1 in 270). Most of these women (86.2%) decided to have an invasive procedure for genetic diagnosis. Nine cases of Down syndrome and 19 cases of other chromosomal anomalies were detected prenatally. Two children with Down syndrome were diagnosed after delivery even though a low estimated risk was determined following the quadruple test. The detection rate was 81.8% (nine out of 11 cases), with a 4.4% false-positive rate. The median multiple of the median value for a-fetoprotein, human chorionic gonadotropin, unconjugated estriol and inhibin A were 0.87, 2.34, 0.77 and 2.16, respectively, in affected cases.ConclusionThis is the first study of the quadruple test for Down syndrome in a Chinese population. Our findings suggested that the second-trimester quadruple test provides an effective screening tool for Down syndrome in Taiwan

Exploring Universal Intrinsic Task Subspace via Prompt Tuning

Why can pre-trained language models (PLMs) learn universal representations and effectively adapt to broad NLP tasks differing a lot superficially? In this work, we empirically find evidence indicating that the adaptations of PLMs to various few-shot tasks can be reparameterized as optimizing only a few free parameters in a unified low-dimensional intrinsic task subspace, which may help us understand why PLMs could easily adapt to various NLP tasks with small-scale data. To find such a subspace and examine its universality, we propose an analysis pipeline called intrinsic prompt tuning (IPT). Specifically, we resort to the recent success of prompt tuning and decompose the soft prompts of multiple NLP tasks into the same low-dimensional nonlinear subspace, then we learn to adapt the PLM to unseen data or tasks by only tuning parameters in this subspace. In the experiments, we study diverse few-shot NLP tasks and surprisingly find that in a 250-dimensional subspace found with 100 tasks, by only tuning 250 free parameters, we can recover 97% and 83% of the full prompt tuning performance for 100 seen tasks (using different training data) and 20 unseen tasks, respectively, showing great generalization ability of the found intrinsic task subspace. Besides being an analysis tool, IPT could further bring practical benefits, such as improving the prompt tuning stability.Comment: Withdrawn from Findings of ACL 202