Income inequality : a summary of the Bank's 1998 Symposium

Income inequality has become an increasingly important public policy issue in industrialized countries in recent years. Although macroeconomic conditions have been favorable in many of these countries, the distribution of income within and across countries has remained uneven. In fact, in several countries, income inequality has risen. As a result, policymakers have become concerned that large segments of the population are not reaping the benefits of economic growth.> To gain a better understanding of these issues, the Federal Reserve Bank of Kansas City sponsored a symposium titled "Income Inequality: Issues and Policy Options" held at Jackson Hole, Wyoming, August 27-29, 1998. The symposium brought together a distinguished group of public officials, academics, and private-sector representatives. The discussion was far-ranging and insightful. As moderator Alice Rivlin noted toward the end of the conference, while there was a divergence of opinion in several areas, there was a consensus that "poverty, deprivation, and lack of opportunity are things that ought to be of great concern to us."> Weiner and Monto summarize the papers and commentary presented at the symposium. The first section reviews the changes in income inequality patterns over the past two decades. The second explores the reasons for these changes. Monetary policy links and the economic impact of distributional change are taken up in the following two sections. The final section considers policy options and summarizes the remarks of an overview panel.Income ; Income distribution

A study of Schwarz converters for nuclear powered spacecraft

High power space systems which use low dc voltage, high current sources such as thermoelectric generators, will most likely require high voltage conversion for transmission purposes. This study considers the use of the Schwarz resonant converter for use as the basic building block to accomplish this low-to-high voltage conversion for either a dc or an ac spacecraft bus. The Schwarz converter has the important assets of both inherent fault tolerance and resonant operation; parallel operation in modular form is possible. A regulated dc spacecraft bus requires only a single stage converter while a constant frequency ac bus requires a cascaded Schwarz converter configuration. If the power system requires constant output power from the dc generator, then a second converter is required to route unneeded power to a ballast load

A postmortem investigation of the Type IIb supernova 2001ig

We present images taken with the GMOS instrument on Gemini-South, in excellent (<0.5 arcsec) seeing, of SN 2001ig in NGC 7424, ~1000 days after explosion. A point source seen at the site of the SN is shown to have colours inconsistent with being an H II region or a SN 1993J-like remnant, but can be matched to a late-B through late-F supergiant with A_V<1. We believe this object is the massive binary companion responsible for periodic modulation in mass loss material around the Wolf-Rayet progenitor which gave rise to significant structure in the SN radio light curve.Comment: 5 pages, 3 figures. Accepted for publication in MNRAS Letters. Fig. 1 resolution degraded to meet size limitations; full resolution version available from http://www.aao.gov.au/local/www/sdr/pubs/sn2001ig_gmos.ps.g

Import of cytochrome c heme lyase into mitochondria

Cytochrome c heme lyase (CCHL) catalyses the covalent attachment of the heme group to apocytochrome c during its import into mitochondria. The enzyme is membrane-associated and is located within the intermembrane space. The precursor of CCHL synthesized in vitro was efficiently translocated into isolated mitochondria from Neurospora crassa. The imported CCHL, like the native protein, was correctly localized to the intermembrane space, where it was membrane-bound. As with the majority of mitochondrial precursor proteins, CCHL uses the MOM19-GIP receptor complex in the outer membrane for import. In contrast to proteins taking the general import route, CCHL was imported independently of both ATP-hydrolysis and an electrochemical potential as external energy sources. CCHL which lacks a cleavable signal sequence apparently does not traverse the inner membrane to reach the intermembrane space; rather, it translocates through the outer membrane only. Thus, CCHL represents an example of a novel, 'non-conservative' import pathway into the intermembrane space, thereby also showing that the import apparatus in the outer membrane acts separately from the import machinery in the inner membrane

Investigation of varying gray scale levels for remote manipulation

A study was conducted to investigate the effects of variant monitor gray scale levels and workplace illumination levels on operators' ability to discriminate between different colors on a monochrome monitor. It was determined that 8-gray scale viewing resulted in significantly worse discrimination performance compared to 16- and 32-gray scale viewing and that there was only a negligible difference found between 16 and 32 shades of gray. Therefore, it is recommended that monitors used while performing remote manipulation tasks have 16 or above shades of gray since this evaluation has found levels lower than this to be unacceptable for color discrimination task. There was no significant performance difference found between a high and a low workplace illumination condition. Further analysis was conducted to determine which specific combinations of colors can be used in conjunction with each other to ensure errorfree color coding/brightness discrimination performance while viewing a monochrome monitor. It was found that 92 three-color combination and 9 four-color combinations could be used with 100 percent accuracy. The results can help to determine which gray scale levels should be provided on monochrome monitors as well as which colors to use to ensure the maximal performance of remotely-viewed color discrimination/coding tasks

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases. However, a lack of pharmacological tools and the absence of convincingly defined endogenous ligands have hampered the understanding of function necessary to exploit it therapeutically. Although several endogenous molecules can activate GPR35 none has yet been confirmed as the key endogenous ligand due to reasons that include lack of biological specificity, non-physiologically relevant potency and species ortholog selectivity. Recent advances have identified several highly potent synthetic agonists and antagonists, as well as agonists with equivalent potency at rodent and human orthologs, which will be useful as tool compounds. Homology modeling and mutagenesis studies have provided insight into the mode of ligand binding and possible reasons for the species selectivity of some ligands. Advances have also been made in determining the role of the receptor in disease. In the past, genome-wide association studies have associated GPR35 with diseases such as inflammatory bowel disease, type 2 diabetes, and coronary artery disease. More recent functional studies have implicated it in processes as diverse as heart failure and hypoxia, inflammation, pain transduction and synaptic transmission. In this review, we summarize the progress made in understanding the molecular pharmacology, downstream signaling and physiological function of GPR35, and discuss its emerging potential applications as a therapeutic target