230 research outputs found
Time-Resolved Studies of a Rolled-Up Semiconductor Microtube Laser
We report on lasing in rolled-up microtube resonators. Time-resolved studies
on these semiconductor lasers containing GaAs quantum wells as optical gain
material reveal particularly fast turn-on-times and short pulse emissions above
the threshold. We observe a strong red-shift of the laser mode during the pulse
emission which is compared to the time evolution of the charge-carrier density
calculated by rate equations
Three-Dimensionally Confined Optical Modes in Quantum Well Microtube Ring Resonators
We report on microtube ring resonators with quantum wells embedded as an
optically active material. Optical modes are observed over a broad energy
range. Their properties strongly depend on the exact geometry of the microtube
along its axis. In particular we observe (i) preferential emission of light on
the inside edge of the microtube and (ii) confinement of light also in
direction of the tube axis by an axially varying geometry which is explained in
an expanded waveguide model.Comment: 5 pages, 4 figure
Analysis of maize brittle-1 alleles and a defective Suppressor-mutator-induced mutable allele.
Corneal Replication Is an Interferon Response-Independent Bottleneck for Virulence of Herpes Simplex Virus 1 in the Absence of Virion Host Shutoff
Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR−/−) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion
All-optical switching and strong coupling using tunable whispering-gallery-mode microresonators
We review our recent work on tunable, ultrahigh quality factor
whispering-gallery-mode bottle microresonators and highlight their applications
in nonlinear optics and in quantum optics experiments. Our resonators combine
ultra-high quality factors of up to Q = 3.6 \times 10^8, a small mode volume,
and near-lossless fiber coupling, with a simple and customizable mode structure
enabling full tunability. We study, theoretically and experimentally, nonlinear
all-optical switching via the Kerr effect when the resonator is operated in an
add-drop configuration. This allows us to optically route a single-wavelength
cw optical signal between two fiber ports with high efficiency. Finally, we
report on progress towards strong coupling of single rubidium atoms to an
ultra-high Q mode of an actively stabilized bottle microresonator.Comment: 20 pages, 24 figures. Accepted for publication in Applied Physics B.
Changes according to referee suggestions: minor corrections to some figures
and captions, clarification of some points in the text, added references,
added new paragraph with results on atom-resonator interactio
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4
The E3 ubiquitin ligase Pellino can be activated by phosphorylation in vitro, catalyzed by IL-1 receptor-associated kinase 1 (IRAK1) or IRAK4. Here, we show that phosphorylation enhances the E3 ligase activity of Pellino 1 similarly with any of several E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b) and identify 7 amino acid residues in Pellino 1 whose phosphorylation is critical for activation. Five of these sites are clustered between residues 76 and 86 (Ser-76, Ser-78, Thr-80, Ser-82, and Thr-86) and decorate a region of antiparallel β-sheet, termed the “wing,” which is an appendage of the forkhead-associated domain that is thought to interact with IRAK1. The other 2 sites are located at Thr-288 and Ser-293, just N-terminal to the RING-like domain that carries the E3 ligase activity. Unusually, the full activation of Pellino 1 can be achieved by phosphorylating any one of several different sites (Ser-76, Thr-86, Thr-288, or Ser-293) or a combination of other sites (Ser-78, Thr-80, and Ser-82). These observations imply that dephosphorylation of multiple sites is required to inactivate Pellino 1, which could be a device for prolonging Pellino's E3 ubiquitin ligase activity in vivo
Dependability modeling and analysis of complex control systems: An application to railway interlocking
Levantamento de dados do banco ativo de germoplasma de Cucurbitáceas da Embrapa Clima Temperado.
- …