Comprehensive Evaluation of Home Visiting New Hampshire: Final Report.

Home Visiting New Hampshire (HVNH) is a statewide initiative of the Division of Public Health Services (DPHS) Bureau of Maternal and Child Health. The program began in 2001 with awards to support programs in 13 sites and expanded in 2002 for a total of 19 sites across New Hampshire. The grantees provide home-based services to Medicaid-eligible pregnant women and their families, particularly those at-risk for poor pregnancy outcomes, child abuse and neglect, substance abuse, and depression. The goals of Home Visiting New Hampshire are to 1. promote healthy pregnancy and birth outcomes. 2. promote a safe and nurturing environment for children. 3. enhance families’ life course and development. In the HVNH program model, specially trained home visitors and nurses regularly visit pregnant women and their families in their homes to deliver a health and parenting education curriculum, information, referrals, and support to participants. This team coordinates its work within the HVNH grantee agency and with the grantee’s partners, i.e., other organizations in the community that can provide needed staff or services. To determine how well the program has succeeded in achieving its goals, DPHS contracted with RMC Research Corporation in November 2002 to conduct a comprehensive evaluation to assess program implementation and outcomes. Data collection involved collecting a large amount of information from participating mothers over multiple points in time while they were in the program, using HVNH Home Visitors and Nurses as the primary data collectors. The evaluation also included surveys of participants and home visiting staff, and information collected about programs through site visits

The Influence of Elementary Silver Versus Titanium on Osteoblasts Behaviour In Vitro Using Human Osteosarcoma Cell Lines

Purpose. The antimicrobial effect of a silver-coated tumor endoprosthesis has been proven in clinical and experimental trials. However, in the literature there are no reports concerning the effect of elementary silver on osteoblast behaviour. Therefore, the prosthetic stem was not silver-coated because of concerns regarding a possible inhibition of the osseointegration. The aim of the present study was to investigate the effect of 5–25 mg of elementary silver in comparison to Ti-6Al-4V on human osteosarcoma cell lines (HOS-58, SAOS). Methods. Cell viability was determined by measuring the MTT proliferation rate. Cell function was studied by measuring alkaline phosphatase (AP) activity and osteocalcine production. Results. In the HOS-58 cells, the AP activity was statistically significant (P < 0.05) higher at a supplement of 5–10 mg of silver than of Ti-6 Al-4V at the same doses. For both cell lines, a supplement above 10 mg of silver resulted in a reduced AP activity in comparision to the Ti-6 Al-4V group, but a statistically significant difference (P < 0.05) was observed at a dose of 25 mg for the SAOS cells only. At doses of 20–25 mg in the HOS-58 cells and 10–25 mg in the SAOS cells, the reduction of the proliferation rate by silver was statistically significant (P < 0.05) compared to the Ti-6 Al-4V supplement. Discussion. In conclusion, elementary silver exhibits no cytotoxicity at low concentrations. In contrast, it seems to be superior to Ti-6 Al-4V concerning the stimulation of osteogenic maturation at these concentrations, whereas at higher doses it causes the known cytotoxic properties

Exercise-heat stress with and without water replacement alters brain structures and impairs visuomotor performance

Effects of exercise�heat stress with and without water replacement on brain structure and visuomotor performance were examined. Thirteen healthy adults (23.6 ± 4.2 years) completed counterbalanced 150 min trials of exercise�heat stress (45°C, 15% RH) with water replacement (EHS) or without (~3% body mass loss; EHS�DEH) compared to seated rest (CON). Anatomical scans and fMRI Blood�Oxygen�Level�Dependent responses during a visuomotor pacing task were evaluated. Accuracy decreased (P 0.50) between structural changes and visuomotor accuracy. EHS�DEH increased neural activation (P < 0.05) within motor and visual areas versus EHS and CON. Brain structural changes are related to bidirectional plasma osmolality perturbations resulting from exercise�heat stress (with and without water replacement), but do not explain visuomotor impairments. Negative impacts of exercise�heat stress on visuomotor tasks are further exacerbated by dehydration

LUMiC(A (R)) Endoprosthetic Reconstruction After Periacetabular Tumor Resection: Short-term Results

Orthopaedics, Trauma Surgery and Rehabilitatio

LUMiC(A (R)) Endoprosthetic Reconstruction After Periacetabular Tumor Resection: Short-term Results

Orthopaedics, Trauma Surgery and Rehabilitatio

LUMiC® Endoprosthetic Reconstruction After Periacetabular Tumor Resection: Short-term Results

Orthopaedics, Trauma Surgery and Rehabilitatio