Aperçu - Surveillance par sentinelle des blessures associées aux brosses à barbecue traitées dans des services d’urgence : la plate-forme électronique du Système canadien hospitalier d’information et de recherche en prévention des traumatismes, 2011-2017

Une brosse à barbecue (BBQ) est un article de ménage très courant destiné à nettoyer les grilles de BBQ. Les données de la base de données de la plate-forme électronique du Système canadien hospitalier d’information et de recherche en prévention des traumatismes (eSCHIRPT) ont été analysées afin d’estimer la fréquence des blessures associées aux brosses à BBQ par rapport à l’ensemble des blessures, ainsi que de décrire les caractéristiques associées à ces accidents. Entre le 1er avril 2011 et le 17 juillet 2017, on a observé des blessures associées aux brosses à une fréquence de 1,5 cas par 100 000 cas dans l’eSCHIRPT (N = 12). Les résultats indiquent qu’outre les risques associés à l’ingestion de poils tombés de la brosse à BBQ et attachés aux aliments, ces poils pourraient aussi causer des blessures par d’autres mécanismes

At-a-glance - Sentinel surveillance of emergency department presentations for barbecue brush-related injuries: the electronic Canadian Hospitals Injury Reporting and Prevention Program, 2011 to 2017

A barbecue (BBQ) brush is a common household item designed for cleaning grills used for barbecuing. Data from the electronic Canadian Hospitals Injury Reporting and Prevention Program database were analysed to estimate the frequency of injuries related to BBQ brushes as a proportion of all injuries, as well as to describe characteristics associated with such injury events. Between April 1, 2011 and July 17, 2017, BBQ brush injuries were observed at a frequency of 1.5 cases per 100 000 eCHIRPP cases (N = 12). Findings suggest that in addition to risks associated with the ingestion of loose BBQ brush bristles attached to foods, loose bristles could also result in injury via other mechanisms

Physical frailty: ICFSR International Clinical Practice Guidelines for Identification and Management

peer reviewedObjective: The task force of the International Conference of Frailty and Sarcopenia Research (ICFSR) developed these clinical practice guidelines to overview the current evidence-base and to provide recommendations for the identification and management of frailty in older adults. Methods: These recommendations were formed using the GRADE approach, which ranked the strength and certainty (quality) of the supporting evidence behind each recommendation. Where the evidence-base was limited or of low quality, Consensus Based Recommendations (CBRs) were formulated. The recommendations focus on the clinical and practical aspects of care for older people with frailty, and promote person-centred care. Recommendations for Screening and Assessment: The task force recommends that health practitioners case identify/screen all older adults for frailty using a validated instrument suitable for the specific setting or context (strong recommendation). Ideally, the screening instrument should exclude disability as part of the screening process. For individuals screened as positive for frailty, a more comprehensive clinical assessment should be performed to identify signs and underlying mechanisms of frailty (strong recommendation). Recommendations for Management: A comprehensive care plan for frailty should address polypharmacy (whether rational or nonrational), the management of sarcopenia, the treatable causes of weight loss, and the causes of exhaustion (depression, anaemia, hypotension, hypothyroidism, and B12 deficiency) (strong recommendation). All persons with frailty should receive social support as needed to address unmet needs and encourage adherence to a comprehensive care plan (strong recommendation). First-line therapy for the management of frailty should include a multicomponent physical activity programme with a resistance-based training component (strong recommendation). Protein/caloric supplementation is recommended when weight loss or undernutrition are present (conditional recommendation). No recommendation was given for systematic additional therapies such as cognitive therapy, problem-solving therapy, vitamin D supplementation, and hormone-based treatment. Pharmacological treatment as presently available is not recommended therapy for the treatment of frailty

Genomics of Post-Prandial Lipidomic Phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study

<div><p>Background</p><p>Increased postprandial lipid (PPL) response to dietary fat intake is a heritable risk factor for cardiovascular disease (CVD). Variability in postprandial lipids results from the complex interplay of dietary and genetic factors. We hypothesized that detailed lipid profiles (eg, sterols and fatty acids) may help elucidate specific genetic and dietary pathways contributing to the PPL response.</p><p>Methods and Results</p><p>We used gas chromatography mass spectrometry to quantify the change in plasma concentration of 35 fatty acids and 11 sterols between fasting and 3.5 hours after the consumption of a high-fat meal (PPL challenge) among 40 participants from the GOLDN study. Correlations between sterols, fatty acids and clinical measures were calculated. Mixed linear regression was used to evaluate associations between lipidomic profiles and genomic markers including single nucleotide polymorphisms (SNPs) and methylation markers derived from the Affymetrix 6.0 array and the Illumina Methyl450 array, respectively. After the PPL challenge, fatty acids increased as well as sterols associated with cholesterol absorption, while sterols associated with cholesterol synthesis decreased. PPL saturated fatty acids strongly correlated with triglycerides, very low-density lipoprotein, and chylomicrons. Two SNPs (rs12247017 and rs12240292) in the sorbin and SH3 domain containing 1 (<i>SORBS1</i>) gene were associated with b-Sitosterol after correction for multiple testing (<i>P</i>≤4.5*10⁻¹⁰). <i>SORBS1</i> has been linked to obesity and insulin signaling. No other markers reached the genome-wide significance threshold, yet several other biologically relevant loci are highlighted (eg, <i>PRIC285</i>, a co-activator of PPARa).</p><p>Conclusions</p><p>Integration of lipidomic and genomic data has the potential to identify new biomarkers of CVD risk.</p></div

Search for W′W' boson production in the W′→tbˉW' \to t\bar{b} decay channel

9 pages, 6 figures, submitted to Phys. Lett. B - D0We present a search for the production of a new heavy gauge boson W' that decays to a top quark and a bottom quark. We have analyzed 230 pb$^{-1}$ of data collected with the \dzero detector at the Fermilab Tevatron collider at a center-of-mass energy of 1.96 TeV. No significant excess of events is found in any region of the final state invariant mass distribution. We set upper limits on the production cross section of W' bosons at the 95% confidence level for several different W' boson masses. We exclude masses below 610 GeV for a W' boson with standard-model-like couplings, below 630 GeV for a W' boson with right-handed couplings that is allowed to decay to both leptons and quarks, and below 670 GeV for a W' boson with right-handed couplings that is only allowed to decay to quarks