Clues to the nature of dark matter from first galaxies

We use thirty-eight high-resolution simulations of galaxy formation between redshift 10 and 5 to study the impact of a 3 keV warm dark matter (WDM) candidate on the high-redshift Universe. We focus our attention on the stellar mass function and the global star formation rate and consider the consequences for reionization, namely the neutral hydrogen fraction evolution and the electron scattering optical depth. We find that three different effects contribute to differentiate warm and cold dark matter (CDM) predictions: WDM suppresses the number of haloes with mass less than few $10^9$ M$_{\odot}$; at a fixed halo mass, WDM produces fewer stars than CDM; and finally at halo masses below $10^9$ M$_{\odot}$, WDM has a larger fraction of dark haloes than CDM post-reionization. These three effects combine to produce a lower stellar mass function in WDM for galaxies with stellar masses at and below $\sim 10^7$ M$_{\odot}$. For $z > 7$, the global star formation density is lower by a factor of two in the WDM scenario, and for a fixed escape fraction, the fraction of neutral hydrogen is higher by 0.3 at $z \sim 6$. This latter quantity can be partially reconciled with CDM and observations only by increasing the escape fraction from 23 per cent to 34 per cent. Overall, our study shows that galaxy formation simulations at high redshift are a key tool to differentiate between dark matter candidates given a model for baryonic physics.Comment: 11 pages, 8 figures, submitted to MNRA

Cavity ring-down spectroscopy for molecular trace gas detection using a pulsed DFB QCL emitting at 6.8 \u3bcm

A trace gas sensor based on pulsed cavity ring-down spectroscopy (CRDS) was developed for measurement of the \u3bd4 fundamental vibrational band of ammonia (NH3) centered at 1468.898 cm-1. A pulsed distributed feedback quantum cascade laser (DFB-QCL) operating at 6.8 \u3bcm (1470.58 cm-1) quite well covered the absorption band of the ammonia and strong fundamental vibrational absorption bands of different molecular gases in this unexplored region. The cavity was partially evacuated down to 0.4 Atm by a turbo-molecular pump to reduce the partial interference between the NH3 spectra and water near the absorption peak of ammonia. A sensitivity of nine parts per billion was reached for a measurement time of 120 s as well as an optical path length of 226 m. The device demonstrated high spectral performance and versatility due to its wide tuning range, narrow linewidth, and comparatively high-energy mid-IR radiation in the relatively unexplored 6.8 \u3bcm region, which is very important for high-resolution spectroscopy of a variety of gases

The study of degradation mechanisms of glyco-engineered plant produced anti-rabies monoclonal antibodies E559 and 62-71-3

Rabies is an ancient and neglected zoonotic disease caused by the rabies virus, a neurotropic RNA virus that belongs to the Rhabdoviridae family, genus Lyssavirus. It remains an important public health problem as there are cost and health concerns imposed by the current human post exposure prophylaxis therapy. The use of monoclonal antibodies (mAbs) is therefore an attractive alternative. Rabies mostly affects people that reside in resource-limited areas where there are occasional failures in the cold-chain. These environmental changes may upset the stability of the mAbs. This study focused on mAbs 62-71-3 and E559; their structures, responses to freeze/thaw (F/T) and exposure to reactive oxygen species were therefore studied with the aid of a wide range of biophysical and in silico techniques in order to elucidate their stability and identify aggregation prone regions. E559 was found to be less stable than 62-71-3. The complementarity determining regions (CDR) contributed the most to its instability, more specifically: peptides (EIWD102)-E-99 and (92)ATSPYT(97) found in CDR3, Trp33 found in CDR1 and the oxidised Met34. The constant region "(158)SWNSGALTGHTFPAVL(175)" was also flagged by the special aggregation propensity (SAP) tool and F/T experiments to be highly prone to aggregation. The E559 peptides "(4)LQESGSVL(11) from the heavy chain and (4)LTQSPSSL(11) from the light chain, were also highly affected by F/T. These residues may serve as good candidates for mutation, in the aim to bring forward more stable therapeutic antibodies, thus paving a way to a more safe and efficacious antibody-based cocktail treatment against rabies

Scaling the mid-IR radiation at 7 μm - Two-stage double-pass 195 MHz narrow-bandwidth DFG laser system

We present a laser system based on difference frequency generation (DFG) to produce tunable, narrow-linewidth (<30 pm), and high-energy mid-IR radiation in the 6785 nm region. The system exploits nonlinear crystals (such as LiInS2, LiInSe2 and BaGa4Se7) and nanosecond pulses generated by single-frequency Nd:YAG and Cr:forsterite lasers at 1064 and 1262 nm, respectively. Various experimental configurations are used: single-pass and double-pass through the nonlinear crystal. Additional increments of the output energy can be obtained by performing two stage double-pass geometry

Intensity distribution for waves in disordered media: deviations from Rayleigh statistics

We study the intensity distribution function, P(I), for monochromatic waves propagating in quasi one-dimensional disordered medium, assuming that a point source and a point detector are embedded in the bulk of the medium. We find deviations from the Rayleigh statistics at moderately large I and a logarithmically-normal asymptotic behavior of P(I). When the radiation source and the detector are located close to the opposite edges of the sample (on a distance much less then the sample length), an intermediate regime with a stretched-exponential behavior of P(I) emerges.Comment: 4 pages Revtex, 3 figures included as eps file

Steps towards the hyperfine splitting measurement of the muonic hydrogen ground state: pulsed muon beam and detection system characterization

The high precision measurement of the hyperfine splitting of the muonic-hydrogen atom ground state with pulsed and intense muon beam requires careful technological choices both in the construction of a gas target and of the detectors. In June 2014, the pressurized gas target of the FAMU experiment was exposed to the low energy pulsed muon beam at the RIKEN RAL muon facility. The objectives of the test were the characterization of the target, the hodoscope and the X-ray detectors. The apparatus consisted of a beam hodoscope and X-rays detectors made with high purity Germanium and Lanthanum Bromide crystals. In this paper the experimental setup is described and the results of the detector characterization are presented.Comment: 22 pages, 14 figures, published and open access on JINS

Party system closure and openness: conceptualization, operationalization and validation

The degree of closure of the governmental arena is a central aspect of the stabilization of party systems, and yet little systematic effort has been devoted to its operationalization. The article proposes a new index, examines its reliability and validity, and reports the ranking of 60 party systems. By redefining the units of measurement we suggest new indicators that are uniform and transparent in their logic of construction, can be applied both to specific government-changes and to time periods, and are sensitive to the degree of change. The article finds a hierarchy among the components of party system closure, dominated by coalition formula. While new and established democracies can both produced closed patterns, the analysis of inter-war European party systems shows that closed systems are less prone to authoritarian takeover. The article demonstrates the power of inertia: the completely closed configurations stand out as the most durable ones

Pine cone scale-inspired motile origami

Stimuli-sensitive hydrogels have received attention because of their potential applications in various fields. Stimuli-directed motion offers many practical applications, such as in drug delivery systems and actuators. Directed motion of asymmetric hydrogels has long been designed; however, few studies have investigated the motion control of symmetric hydrogels. We designed a pine cone scale-inspired movable temperature-sensitive symmetric hydrogel that contains Fe3O4. Alignment of Fe3O4 along the magnetic force is key in motion control in which Fe3O4 acts like fibers in a pine cone scale. Although a homogeneous temperature-sensitive hydrogel cannot respond to a temperature gradient, the Fe3O4-containing hydrogel demonstrates considerable bending motion. Varying degrees and directions of motion are easily facilitated by controlling the amount and alignment angle of the Fe3O4. The shape of the hydrogel layer also influences the morphological structure. This study introduced facile and low-cost methods to control various bending motions. These results can be applied to many fields of engineering, including industrial engineering.111Ysciescopu

First measurement of the temperature dependence of muon transfer rate from muonic hydrogen atoms to oxygen

We report the first measurement of the temperature dependence of muon transfer rate from muonic hydrogen atoms to oxygen between 100 and 300 K. Data were obtained from the X-ray spectra of delayed events in a gaseous target, made of a H2/O2 mixture, exposed to a muon beam. This work sets constraints on theoretical models of muon transfer and is of fundamental importance for the measurement of the hyperfine splitting of muonic hydrogen ground state as proposed by the FAMU collaboration

First measurement of the temperature dependence of muon transfer rate from muonic hydrogen atoms to oxygen

We report the first measurement of the temperature dependence of muon transfer rate from muonic hydrogen atoms to oxygen between 100 and 300 K. Data were obtained from the X-ray spectra of delayed events in a gaseous target, made of a H2/O2 mixture, exposed to a muon beam. This work sets constraints on theoretical models of muon transfer and is of fundamental importance for the measurement of the hyperfine splitting of muonic hydrogen ground state as proposed by the FAMU collaboration