Household Laundry Detergent as a Possible Cause of Oral Lichenoid Lesions

Oral lichenoid lesions (OLLs) are a diverse group of disorders that may be attributed to an autoimmune etiology, underlying systemic disease, or in association with an identifiable causative agent, such as a medication, food product, or dental material. OLLs commonly present with striae, erythema, and/or ulceration on affected oral mucosa and can be symptomatic. The aim of this report is to describe a case of OLLs that were believed to be attributed to use of household laundry detergent to clean an oral occlusal appliance

Topical and Systemic Therapies for Oral and Perioral Herpes Simplex Virus Infections

Oral and perioral herpes simplex virus (HSV) infections in healthy individuals often present with signs and symptoms that are clearly recognized by oral health care providers (OHCPs). Management of these infections is dependent upon a variety of factors and several agents may be used for treatment to accelerate healing and decrease symptoms associated with lesions. This article will review the pertinent aspects of topical and systemic therapies of HSV infections for the OHCP

Pemphigus

Pemphigus vulgaris and paraneoplastic pemphigus are two subtypes of pemphigus that involve the oral mucosa. These autoimmune blistering disorders have antibodies targeted against proteins of keratinocyte adhesion, thereby causing acantholysis. Clinical findings include oral erosions and flaccid cutaneous bullae and erosions. In addition to the clinical exam, diagnostic tests including tissue biopsy, direct and indirect immunofluorescence, and enzyme-linked immunosorbent assays (ELISA) help to establish a diagnosis. Further malignancy workup in patients with suspected paraneoplastic pemphigus is warranted. Retrospective uncontrolled studies suggest that immunosuppressive agents reduce mortality in pemphigus vulgaris and cohort uncontrolled studies of rituximab, a monoclonal antibody against CD20, suggest it is an effective treatment for refractory patients. Ongoing studies will define its role in early disease