Patterns and drivers of movement for a coastal benthopelagic fish, Pseudocaranx georgianus, on Australia's southeast coast.

Knowledge of connectivity and population structure is integral to the sustainable management of fished populations, yet such information is unavailable for many species over scales relevant to their exploitation. We examined broad-scale patterns and drivers of adult movement for a putatively mobile carangid (Pseudocaranx georgianus) on Australia's southeast coast using an angler tag-recapture dataset. More than 6300 individuals were tagged and released across 1007 km of coastline, with anglers recapturing 157 (2.48%) individuals during a 14-year period. Median distance moved was 5 km and a substantial proportion of individuals (19%) were recaptured at their release location. Recapture latitude was also strongly predicted by release latitude (r2 = 0.87). However, a broad range of movements were observed (0-508 km), with 6% of individuals moving further than 100 km. Most individuals recaptured in areas now designated as Marine Protected Areas (MPAs) were originally released in the same area (79.2%). Larger body size, longer periods at liberty, and releases during Spring all positively influenced distance moved. Results support restricted movement over an intermediate scale, punctuated by occasional large movements. Our findings suggest adult movement of P. georgianus in southeastern Australia primarily occurs over smaller distances than the current spatial scale of management

Climate services for health: from global observations to local interventions

Despite the wealth of available climate data available, there is no consensus on the most appropriate product choice for health impact modelling and how this influences downstream climate-health decisions. We discuss challenges related to product choice, highlighting the importance of considering data biases and co-development of climate services between different sectors

Determining the relative contribution of retinal disparity and blur cues to ocular accommodation in Down syndrome

Individuals with Down syndrome (DS) often exhibit hypoaccommodation alongside accurate vergence. This study investigates the sensitivity of the two systems to retinal disparity and blur cues, establishing the relationship between the two in terms of accommodative-convergence to accommodation (AC/A) and convergence-accommodation to convergence (CA/C) ratios. An objective photorefraction system measured accommodation and vergence under binocular conditions and when retinal disparity and blur cues were removed. Participants were aged 6–16 years (DS n = 41, controls n = 76). Measures were obtained from 65.9% of participants with DS and 100% of controls. Accommodative and vergence responses were reduced with the removal of one or both cues in controls (p < 0.007). For participants with DS, removal of blur was less detrimental to accommodative responses than removal of disparity; accommodative responses being significantly better when all cues were available or when blur was removed in comparison to when proximity was the only available cue. AC/A ratios were larger and CA/C ratios smaller in participants with DS (p < 0.00001). This study demonstrates that retinal disparity is the main driver to both systems in DS and illustrates the diminished influence of retinal blur. High AC/A and low CA/C ratios in combination with disparity-driven responses suggest prioritisation of vergence over accurate accommodation

Small molecule additive for low-power accumulation mode organic electrochemical transistors

A small molecule additive, dodecylbenzenesulfonate (DBSA), is added to the electrolyte in OECTs to improve the device performance.ERC IMBIBE EPSRC CDT Plastic Electronic

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer

The significance of the inter-relationship between tumour and host local/systemic inflammatory responses in primary operable invasive breast cancer is limited. The inter-relationship between the systemic inflammatory response (pre-operative white cell count, C-reactive protein and albumin concentrations), standard clinicopathological factors, tumour T-lymphocytic (CD4+ and CD8+) and macrophage (CD68+) infiltration, proliferative (Ki-67) index and microvessel density (CD34+) was examined using immunohistochemistry and slide-counting techniques, and their prognostic values were examined in 168 patients with potentially curative resection of early-stage invasive breast cancer. Increased tumour grade and proliferative activity were associated with greater tumour T-lymphocyte (P&lt;0.05) and macrophage (P&lt;0.05) infiltration and microvessel density (P&lt;0.01). The median follow-up of survivors was 72 months. During this period, 31 patients died; 18 died of their cancer. On univariate analysis, increased lymph-node involvement (P&lt;0.01), negative hormonal receptor (P&lt;0.10), lower albumin concentrations (P&lt;0.01), increased tumour proliferation (P&lt;0.05), increased tumour microvessel density (P&lt;0.05), the extent of locoregional control (P&lt;0.0001) and limited systemic treatment (Pless than or equal to0.01) were associated with cancer-specific survival. On multivariate analysis of these significant covariates, albumin (HR 4.77, 95% CI 1.35–16.85, P=0.015), locoregional treatment (HR 3.64, 95% CI 1.04–12.72, P=0.043) and systemic treatment (HR 2.29, 95% CI 1.23–4.27, P=0.009) were significant independent predictors of cancer-specific survival. Among tumour-based inflammatory factors, only tumour microvessel density (P&lt;0.05) was independently associated with poorer cancer-specific survival. The host inflammatory responses are closely associated with poor tumour differentiation, proliferation and malignant disease progression in breast cancer

Campbell Standards: Modernizing Campbell\u27s Methodologic Expectations for Campbell Collaboration Intervention Reviews (MECCIR)

\ua9 2024 The Author(s). Campbell Systematic Reviews published by John Wiley &amp; Sons Ltd on behalf of The Campbell Collaboration. Introduction: The authors formed a small working group to modernize the Methodological Expectations for Campbell Collaboration Intervention Reviews (MECCIR). We reviewed comments and feedback from editors, peer reviewers of Campbell submissions, and authors; for example, that the Campbell MECCIR was long and some of the items in the reporting and conduct checklists were difficult to cross-reference. We also wanted to make the checklist more relevant for reviews of associations or risk factors and other quantitative non-intervention review types, which we welcome in Campbell. Thus, our aim was to develop a shorter, more holistic guidance and checklist of Campbell Standards, encompassing both conduct and reporting of these standards within the same checklist. Methods: Our updated Campbell Standards will be a living document. To develop this first iteration, we invited Campbell members to join a virtual working group; we sought experience in conducting Campbell systematic reviews and in conducting methods editor reviews for Campbell. We aligned the items from the MECCIR for conduct and reporting, then compared the principles of conduct that apply across review types to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-literature search extension (S) and PRISMA-2020 reporting standards. We discussed each section with the aim of developing a parsimonious checklist with explanatory guidance while avoiding losing important concepts that are relevant to all types of reviews. We held nine meetings to discuss each section in detail between September 2022 and March 2023. We circulated this initial checklist and guidance to all Campbell editors, methods editors, information specialists and co-chairs to seek their feedback. All feedback was discussed by the working group and incorporated to the Standards or, if not incorporated, a formal response was returned about the rationale for why the feedback was not incorporated. Campbell Policy: The guidance includes seven main sections with 35 items multifaceted but distinct concepts that authors must adhere to when conducting Campbell reviews. Authors and reviewers must be mindful that multiple factors need to be assessed for each item. According to the Campbell Standards, the reporting of Campbell reviews must adhere to appropriate PRISMA reporting guidelines(s) such as PRISMA-2020. How to Use: The editorial board recommends authors use the checklist during their work in formulating their protocol, carrying out their review, and reporting it. Authors will be asked to submit a completed checklist with their submission. We plan to develop an online tool to facilitate use of the form by author teams and those reviewing submissions. Providing Feedback: We invite the scientific community to provide their comments using this anonymous google form. Plan for Updating: We will update the Campbell Standards periodically in light of new evidence

A novel MT-CO2 variant causing cerebellar ataxia and neuropathy: The role of muscle biopsy in diagnosis and defining pathogenicity

Pathogenic variants in mitochondrial DNA (mtDNA) are associated with significant clinical heterogeneity with neuromuscular involvement commonly reported. Non-syndromic presentations of mtDNA disease continue to pose a diagnostic challenge and with genomic testing still necessitating a muscle biopsy in many cases. Here we describe an adult patient who presented with progressive ataxia, neuropathy and exercise intolerance in whom the application of numerous Mendelian gene panels had failed to make a genetic diagnosis. Muscle biopsy revealed characteristic mitochondrial pathology (cytochrome c oxidase deficient, ragged-red fibers) prompting a thorough investigation of the mitochondrial genome. Two heteroplasmic MT-CO2 gene variants (NC_012920.1: m.7887G>A and m.8250G>A) were identified, necessitating single fiber segregation and familial studies – including the biopsy of the patient's clinically-unaffected mother - to demonstrate pathogenicity of the novel m.7887G>A p.(Gly101Asp) variant and establishing this as the cause of the mitochondrial biochemical defects and clinical presentation. In the era of high throughput whole exome and genome sequencing, muscle biopsy remains a key investigation in the diagnosis of patients with non-syndromic presentations of adult-onset mitochondrial disease and fully defining the pathogenicity of novel mtDNA variants

Identification of hip fracture patients from radiographs using Fourier analysis of the trabecular structure: a cross-sectional study

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