Sensitivity to Ingested Sulfites

Sulfiting agents, including sodium and potassium bisulfite, sodium and potassium metabisulfite, sodium sulfite, and sulfur dioxide, have enjoyed widespread use as food and drug ingredients. The oral ingestion of these sulfiting agents is now known to trigger asthma in a small subset of the asthmatic population. The best evidence suggests that perhaps 150,000 to 200,000 individuals in the United States may be sulfite sensitive. Although the mechanism of sulfite-induced asthma remains unknown, several possibilities have been considered, including inhalation of sulfur dioxide (SO2) while swallowing, an IgE-mediated reaction, and a deficiency of sulfite oxidase leading to impaired sulfite metabolism and excretion. The only treatment for sulfite sensitivity is avoidance of sulfites in foods and drugs

Allergenic Foods

Virtually all food allergens are proteins, although only a small percentage of the many proteins in foods are allergens. Any food that contains protein has the potential to cause allergic reactions in some individuals. However, a few foods or food groups are known to cause allergies on a more frequent basis than other foods. At a 1995 consultation on food allergies sponsored by the Food and Agriculture Organization, a group of international experts confirmed that peanuts, soybeans, crustacea, fish, cow’s milk, eggs, tree nuts, and wheat are the most common allergenic foods. These foods are responsible for more than 90% of serious allergic reactions to foods. Allergies to certain fresh fruits and vegetables are also rather common, but the allergens tend to be labile to processing and cooking and the symptoms are mild and confined primarily to the oropharyngeal area. The prevalence of allergic sensitivities to specific foods varies from one country to another depending on the frequency with which the food is eaten in that country and the typical age at its introduction into the diet. For example, peanuts are a much more frequent cause of food allergies in the United States than in most other countries. Americans eat peanuts more often and introduce peanut butter into the diet of children at an early age. The Japanese probably experience more soybean and rice allergies than some other cultures because of the frequency of these two foods in the Japanese diet. Scandinavians have a high incidence of codfish allergy for similar reasons. Table 1 provides a listing of the most common allergenic foods and food groups compiled from a thorough search of the medical literature. Table 2 provides a listing of the less common allergenic foods. Only some of the foods listed in this table have been documented to cause severe, life-threatening allergic reactions. Citations are provided to studies and/or case reports that document the allergenicity of those particular foods. The absence of a particular food on this list may not mean that it is nonallergenic but may indicate that its allergenicity has not been documented. Conversely, the presence of a specific food on the list merely indicates that it has been listed in one or more reports as a cause of food allergy and does not indicate the prevalence or potential as an allergenic food

Sulfites

Key Concepts Sulfites are frequently used food and drug additives. Ingestion of sulfite residues has been documented to trigger asthmatic reactions in sensitive individuals. Sulfite-induced asthma occurs in less than 5% of asthmatic individuals, and those with severe, persistent asthma are at greatest risk. The diagnosis of sulfite-induced asthma is best made by blinded oral challenge with assessment of lung function. Labeling regulations in the United States alert sulfite-sensitive individuals to the presence of sulfites in foods, which must then be avoided

Sulfite Residues in Maraschino Cherries

A survey of 53 samples of maraschino cherries from 14 different processors revealed that total sulfite residues averaged 52.3 ± 44.7 ppm. However, 58.5% of the samples had less than 40 ppm total SO2, while only 7.6% had greater than 120 ppm total SO2 indicating that the distribution was skewed in the direction of lower residue levels. Free sulfite residues in the 53 samples were considerably lower, averaging 14.2 ± 7.1 ppm. With free SO2 levels, 35.8% of the samples had less than 10 ppm free SO2, while only 5.7% had greater than 30 ppm free SO2. With an average serving size of one cherry (3–7 g), maraschino cherries would contribute only 0.16–0.37 mg per serving of total sulfites as SO2

Preliminary Investigation of Rural-Use Aquifers of Boone, Carroll, and Madison Counties, Arkansas

Approximately 500 water wells having driller\u27s lithologic logs were plottedin Boone, Carroll, and Madison Counties, Arkansas. Three aquifers were found to be used by the rural residents and smaller communities. The most shallow of these is the Mississippian Boone-St. Joe aquifer. This aquifer is generally the least productive having a range of .25 to 60 gpm but a median productivity of only 5 gpm. Well depths for the Boone-St. Joe range from 46 to 464 ft. and have a median depth of 225 ft. The Boone-St. Joe aquifer is unconfined to semi-confined and yields sufficient quantities of water only when there is an adequate saturated thickness (generally\u3e100 ft.) and/or a fracture or water-filled cave is intersected. The next aquifer is the first sand below the Chattanooga Shale which can be composed on one to three of the following sandstones: upper Everton, Clifty, and/or Sylamore. The range in yield for this newly designated aquifer is 1 to 70 gpm with a median productivity of 10 gpm. Well depths for the aquifer range from 150 to 824 ft. with a median depth of 460 feet. An isopach map was prepared for this sandstone aquifer zone. There is a rapid thinning trend to the north from 250 ft in central Madison County to 0 ft near the Missouri border. If there is insufficiency or permeability of this aquifer, residents must drill deeper to the Cotter Dolomite. The Cotter-Jefferson City Dolomite is the next aquifer below the Sylamore-Clifty-Everton aquifer. This aquifer zone has a range in yield of 1.5 to 200 gpm and a median yield of 15 gpm. Well depths range from 130 to 1010 ft. with a median depth of 475 feet. A statistical correlation procedure was made among well yield (gpm), photo-lineament proximity, and regolith thickness for all these aquifers in Boone County. The results indicate that more water can be obtained in areas of deep weathering and that deeper weathering is found closer to photo-lineaments. A strong relationship between lineament proximity and yield exists when the aquifers are combined but not for each of the individual aquifers

Evaluation of a Handheld Gluten Detection Device

A portable, handheld gluten detection device, the Nima sensor, is now available for consumers wishing to determine if gluten is present in food. By U.S. regulation, gluten-free foods should contain \u3c 20 ppm of gluten. Thirteen gluten-free foods (muffins, three different types of bread, three different types of pasta, puffed corn snack, ice cream, meatballs, vinegar and oil salad dressing, oatmeal, and dark chocolate) were prepared; each food was spiked on a weight-to-weight basis with gluten levels of 0, 5, 10, 20, 30, 40, and 100 ppm before processing or preparation. Unprocessed and processed foods were tested with the handheld gluten sensor and by two gluten-specific enzyme-linked immunosorbent assays (ELISAs) on the basis of the R5 and G12 monoclonal antibodies, respectively. The portable gluten detection device detected gluten in all food types at the 30-ppm addition level, failing to detect gluten in only 5 (6.4%) of 78 subsamples. At the 20-ppm addition level, the portable gluten detection device failed to detect gluten in one type of pasta but detected gluten residues in 63 (87.5%) of 72 other subsamples. The device was able to detect gluten at the 10-ppm addition level in 9 of the 13 food matrices (41 of 54 subsamples, 75.9%) but not in the three types of pasta and the puffed corn snack. The gluten-sensing device did not perform reliably at the 5-ppm addition level in 11 of 13 food matrices (exceptions: ice cream and muffins). In contrast, the ELISA methods were highly reliable at gluten addition levels of ≥ 10 ppm in all food matrices. The portable gluten detection device yielded a low percentage of false-positive results (4 of 111, 3.6%) in these food matrices. Thus, this handheld portable gluten sensor performed reliably in the detection of gluten in foods having ≥ 20 ppm of added gluten with only 18 (5.9%) of 306 failures, if results of the one type of pasta are excluded. The device worked with greater reliability as the gluten levels in the foods increased

Challenges in Gluten Analysis: A Comparison of Four Commercial Sandwich ELISA Kits

Gluten is composed of prolamin and glutelin proteins from several related grains. Because these proteins are not present in identical ratios in the various grains and because they have some differences in sequence, the ability to accurately quantify the overall amount of gluten in various food matrices to support gluten-free labeling is difficult. Four sandwich ELISAs (the R-Biopharm AG R5 RIDASCREEN®, the Neogen Veratox® R5, the Romer Labs AgraQuant® G12, and the Morinaga Wheat kits) were evaluated for their performance to quantify gluten concentrations in various foods and ingredients. The Morinaga and AgraQuant® G12 tests yielded results comparable to the two R5 kits for most, but not for certain, foods. The results obtained with the Morinaga kit were lower when compared to the other kits for analyzing powders of buckwheat and several grass-based products. All four kits were capable of detecting multiple gluten-containing grain sources including wheat, rye, barley, semolina, triticale, spelt, emmer, einkorn, Kamut™, and club wheat. Users of the ELISA kits should verify the performance in their hands, with matrices that are typical for their specific uses. The variation in results for some food matrices between test methods could result in trade disputes or regulatory disagreements

The Key Events Dose-Response Framework: A Foundation for Examining Variability in Elicitation Thresholds for Food Allergens

Food allergies are caused by immunological reactions in individuals sensitized to normal protein components of foods. For any given sensitized individual, the severity of a reaction is generally assumed to be proportional to the dose of allergenic protein. There is substantial clinical evidence that “threshold” doses exist for the elicitation of an allergic reaction; however, the threshold (i.e., lowest dose that elicits a reaction) varies substantially across the sensitized population. Current approaches to protecting sensitized individuals from exposure to food allergens are highly qualitative (i.e., they rely on food avoidance). The Key Events Dose-Response Framework is an analytical approach for refining understanding of the biological basis of the dose-response. Application of this approach to food allergy provides a foundation for a more rigorous quantitative understanding of variability in allergic response. This study reviews the allergic disease process and the current approaches to identifying thresholds for food allergens. The pathway of key biological events occurring between food intake and allergic response is considered, along with factors that may determine the nature and severity of response to food allergens. Data needs, as well as implications for identifying thresholds, and for characterizing variability in thresholds, are also discussed