896 research outputs found
Strikers and Subsidies: The Influence of Government Transfer Programs on Strike Activity
The authors assess laws governing striker eligibility for government transfers, finding evidence linking UI payments to strike activity.https://research.upjohn.org/up_press/1106/thumbnail.jp
Setting the Stage
The authors assess laws governing striker eligibility for government transfers, finding evidence linking UI payments to strike activity.https://research.upjohn.org/up_press/1106/thumbnail.jp
Eight-Dimensional Mid-Infrared/Optical Bayesian Quasar Selection
We explore the multidimensional, multiwavelength selection of quasars from
mid-IR (MIR) plus optical data, specifically from Spitzer-IRAC and the Sloan
Digital Sky Survey (SDSS). We apply modern statistical techniques to combined
Spitzer MIR and SDSS optical data, allowing up to 8-D color selection of
quasars. Using a Bayesian selection method, we catalog 5546 quasar candidates
to an 8.0 um depth of 56 uJy over an area of ~24 sq. deg; ~70% of these
candidates are not identified by applying the same Bayesian algorithm to
4-color SDSS optical data alone. Our selection recovers 97.7% of known type 1
quasars in this area and greatly improves the effectiveness of identifying
3.5<z<5 quasars. Even using only the two shortest wavelength IRAC bandpasses,
it is possible to use our Bayesian techniques to select quasars with 97%
completeness and as little as 10% contamination. This sample has a photometric
redshift accuracy of 93.6% (Delta Z +/-0.3), remaining roughly constant when
the two reddest MIR bands are excluded. While our methods are designed to find
type 1 (unobscured) quasars, as many as 1200 of the objects are type 2
(obscured) quasar candidates. Coupling deep optical imaging data with deep
mid-IR data could enable selection of quasars in significant numbers past the
peak of the quasar luminosity function (QLF) to at least z~4. Such a sample
would constrain the shape of the QLF and enable quasar clustering studies over
the largest range of redshift and luminosity to date, yielding significant
gains in our understanding of quasars and the evolution of galaxies.Comment: 49 pages, 14 figures, 7 tables. AJ, accepte
An 800-million-solar-mass black hole in a significantly neutral Universe at redshift 7.5
Quasars are the most luminous non-transient objects known and as a result
they enable studies of the Universe at the earliest cosmic epochs. Despite
extensive efforts, however, the quasar ULAS J1120+0641 at z=7.09 has remained
the only one known at z>7 for more than half a decade. Here we report
observations of the quasar ULAS J134208.10+092838.61 (hereafter J1342+0928) at
redshift z=7.54. This quasar has a bolometric luminosity of 4e13 times the
luminosity of the Sun and a black hole mass of 8e8 solar masses. The existence
of this supermassive black hole when the Universe was only 690 million years
old---just five percent of its current age---reinforces models of early
black-hole growth that allow black holes with initial masses of more than about
1e4 solar masses or episodic hyper-Eddington accretion. We see strong evidence
of absorption of the spectrum of the quasar redwards of the Lyman alpha
emission line (the Gunn-Peterson damping wing), as would be expected if a
significant amount (more than 10 per cent) of the hydrogen in the intergalactic
medium surrounding J1342+0928 is neutral. We derive a significant fraction of
neutral hydrogen, although the exact fraction depends on the modelling.
However, even in our most conservative analysis we find a fraction of more than
0.33 (0.11) at 68 per cent (95 per cent) probability, indicating that we are
probing well within the reionization epoch of the Universe.Comment: Updated to match the final journal versio
Isotopes of nitrogen on Mars: Atmospheric measurements by Curiosity's mass spectrometer
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102173/1/wong_readme.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102173/2/wong2013_SM_v4b.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102173/3/grl51166.pd
Design and implementation of the NUV/optical widefield Star Formation Camera for the Theia Observatory
The Star Formation Camera (SFC) is a wide-field (~19'×~15', >280 arcmin^2), high-resolution (18 mas pixels) UV/optical dichroic camera designed for the Theia 4-m space-borne space telescope concept. SFC will deliver diffraction-limited images at λ > 300 nm in both a blue (190-517nm) and a red (517-1075nm) channel simultaneously. The goal is to conduct a comprehensive and systematic study of the astrophysical processes and environments relevant for the births and life cycles of stars and their planetary systems, and to investigate the range of environments, feedback mechanisms, and other factors that most affect the outcome of star and planet formation
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma
Polymorphisms in Base Excision Repair Genes as Colorectal Cancer Risk Factors and Modifiers of the Effect of Diets High in Red Meat
A diet high in red meat is an established colorectal cancer (CRC) risk factor. Carcinogens generated during meat cooking have been implicated as causal agents, and can induce oxidative DNA damage, which elicits repair by the base excision repair (BER) pathway
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