17 research outputs found
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
- Gejman Pablo V.
- Geus Eco J C
- Gieger Christian
- Gigante Bruna
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- Glass Daniel
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- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
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- Isomaa Bo
- Jackso Anne U.
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- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
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- Johnson Paul
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- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
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- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
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- Kathiresan Sekar
- Kerr-Conte Julie
- Ketkar Shamika
- Kettunen Johannes
- Khaw Kay Tee
- Kiemeney Lambertus A.
- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
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- Lambrechts Diether
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- Leander Karin
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- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
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- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
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- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
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- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
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- Metspalu Andres
- Meyre David
- Midthjell Kristian
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- Moffatt Miriam F.
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- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
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- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
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- Nemes James
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- Neville Matt J.
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- Nilsson Peter
- Nisbet James
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- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
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- O'Donnell Christopher J.
- O'Rahilly Stephen
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- Offer Alison
- Ohlsson Claes
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- Olsson Gunnar
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- Ostenson Claes-Göran
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- Palmer Lyle J.
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- Parts Leopold
- Paré Guillaume
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- Peden John F.
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- Peltonen Leena
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- Peter M Visscher
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- Pietiläinen Kirsi H.
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- Purcell Shaun
- Qi Lu
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- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
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- Rice Catherine
- Ridderstråel Martin
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- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
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- Rocheleau Ghislain
- Roden Michael
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- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
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- Sanders Alan R.
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- Silander Kaisa
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- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
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- Sovio Ulla
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- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
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- Sun Qi
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- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
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- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
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- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
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- Tzenova Bell Jordana
- Tönjes Anke
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- Uitterlinden Andre
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- van Dam Rob M.
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- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
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- Viikari Jorma
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- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
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- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
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- Bao Weidong
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- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
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- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
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- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
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- Bell Emma
- Bell George I.
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Widaa Sara
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- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
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- Baggott R
- Bagshaw J
- Baguley D
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- Baillie J.K.
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- Bakali M
- Bakau M
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- Bandula Steven
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- Oliver Catherine
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- Xie Cheng
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- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Modelling human choices: MADeM and decision‑making
- Author
- Abbasi Samira
- Abbasi Samira
- Ahmad Subutai
- Ahn Sungwoo
- Aldrovandi Silvio
- Alexander William
- Ali Rehman
- Amaducci Rodrigo
- Andermann Martin
- Anderson William S.
- Andras Peter
- Andreassen Ole A
- Andreassen Ole A.
- Angulo Sergio L
- Antic Srdjan D
- Antolík Jan
- Arleo Angelo
- Asada Minoru
- Ashby Michael C
- Azizi Amir Hossein
- Babaie Tahereh
- Bakker Rembrandt
- Balaguer-Ballester Emili
- Barkat Tania R.
- Barri Alessandro
- Bauermeister Christoph
- Bayati Mehdi
- Beeman David
- Beggs John
- Beier Julia
- Belić Jovana J.
- Berdondini Luca
- Berg Rune W.
- Bernard Christophe
- Bernard Christophe
- Bernardi Davide
- Bernardi Davide
- Bettella Francesco
- Blackwell Kim T.
- Blumberger Daniel M.
- Boahen Frank
- Boatman-Reich Dana
- Boi Fabio
- Boothe David L.
- Boothe David L.
- Braun Jochen
- Bridger Emma
- Brochier Thomas
- Brunel Nicolas
- Bryson Alexander
- Buchin Anatoly
- Buhry Laure
- Burkitt Anthony N.
- Butera Robert
- Bächle Johanna
- Calabrese Ronald L.
- Campo Adria Tauste
- Canals Santiago
- Carrillo Richard R.
- Casali Stefano
- Casellato Claudia
- Cazé Romain D
- Chauhan Ankur
- Chen Nan-yow
- Chen Nan-Yow
- Cheng Sen
- Chiappalone Michela
- Chien Shih-Cheng
- Chizhov Anton
- Chizhov Anton V.
- Choi Woochul
- Christensen Rasmus K.
- Chuang Chao-Chun
- Coca Daniel
- Cohen Charles C.
- Courtiol Julie
- Covolan Roberto J. M.
- Crone Joshua C.
- Crone Joshua C.
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- Cumming Ben
- Curio Gabriel
- Cymbalyuk Gennady
- Dabrovska Paulina
- Dahmen David
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- Daun Silvia
- Dave Austin I.
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- Deraeve James
- Desrosiers Patrick
- Destexhe Alain
- Devor Anna
- Di Marco Stefano
- Diaz-Pier Sandra
- Diba Kamran
- Diesmann Markus
- Diggelmann Roland
- DiGregorio David A.
- Dijkstra Tjeerd M.H.
- Dimitrov Alexander G.
- Ditlevsen Susanne
- Djurovic Srdjan
- Doloc-Mihu Anca
- Doncieux Stéphane
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- Doyon Nicolas
- Drach Andrew
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- Dumont Grégory
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- Gutkin Boris
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- Hadrava Michal
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- Halgren Eric
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- Santos Joao
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- Saudargiene Ausra
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- Schmidt Dominik
- Schmidt Maximilian
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- Shi Ying
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- Tetzlaff Christian
- Tetzlaff Tom
- Tewatia Parul
- Thiele Alexander
- Tiesinga Paul
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- Van Geit Werner
- Varona Pablo
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- Vassena Eliana
- Vellmer Sebastian
- Verbist Christophe
- Vich Catalina
- Viswanathan Shivakumar
- Voges Nicole
- Walton Marlei
- Wernecke Hendrik
- Wiechert Martin T.
- Wiskott Laurenz
- Wong Willy
- Woodman Marmaduke
- Wree Andreas
- Yakimova Elena G
- Yamakawa Toshitaka
- Yates Stuart
- Yi Jane
- Yonekura Shogo
- Yu Alfred B.
- Zadeh Ali Sadegh
- Zandt Bas-Jan
- Zandt Bas-Jan
- Zhang Zhong
- Zucca Stefano
- Zulfiqar Isma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)
Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.
- Author
- Ahmed Munaza
- Aitken Stuart
- Aitman Timothy
- Akawi Nadia
- Al Turki Saeed
- Alachkar Hana
- Ali Sonia
- Allen Hana Lango
- Allen Louise
- Allsup David
- Alvi Mohsan
- Ambegaonkar Gautum
- Ambridge Kirsty
- Anderson Carl
- Anderson Julie
- Anjum Uruj
- Anney Richard
- Antony Dinu
- Antrobus Richard
- Archer Hayley
- Armstrong Ruth
- Armstrong Ruth
- Arno Gavin
- Artigas Maria Soler
- Arumugakani Gururaj
- Ashford Sofie
- Astle William
- Attwood Antony
- Austin Steve
- Awada Jana
- Ayub Muhammad
- Bacchelli Chiara
- Bakchoul Tamam
- Balasubramaniam Senduran
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Bariana Tadbir K.
- Barnicoat Angela
- Barrett Daniel M.
- Barrett Jeffrey C.
- Barrett Jeffrey C.
- Barroso Inês
- Batstone Paul
- Baty David
- Baxendale Helen
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- Beales Phil
- Bennett Chris
- Bennett David
- Bentham Jamie
- Berg Jonathan
- Bernhard Birgitta
- Bethune Claire
- Bevan A. Paul
- Bhattacharya Shoumo
- Bibi Shahnaz
- Birney Ewan
- Bitner-Glindzicz Maria
- Bitner-Glindzicz Maria
- Blackwood Douglas
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- Clasper Susan
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- Vijayarangakannan Parthiban
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- Wain Louise V.
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- Wakeling Emma
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- Walters James T.R.
- Wang Guangbiao
- Wang Jun
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- Wassmer Evangeline
- Waters Jonathon
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- Wellesley Diana
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- Wright Michael
- Xu ChangJiang
- Yang Jian
- Yates Laura
- Yau Michael
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- Yong Patrick
- Young Tim
- Yu Ping
- Zhang Fend
- Zhang Pingbo
- Publication venue
- AJHG
- Publication date
- 01/01/2019
- Field of study
The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
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- Abusamra Yousuf
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- Ahmad Norfaizan
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- Kremling Julius
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- McArthur Colin J.
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- McGuinness Shay P.
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
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- Ralston Maximillian
- Ramakrishnan N
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- Saull Michelle
- Saunders Christina T.
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- Spong Adam
- Sprinckmoller Stefan
- Squires Rebecca
- Stambaugh Martha
- Stammers Katie
- Stanciu Delia
- Stanley Timothy
- Stanworth Simon
- Stapleton Liana
- Starke Lisa
- Stavor Dara
- Stedman Roger
- Steffen Melanie
- Stephanie Gelinotte
- Stephens Deanna
- Stevenson Lesley
- Stewart Richard
- Stienstra Riejanne
- Stone Sarah
- Stowe Bethan
- Stratton Emma
- Stronach Lucy
- Suber Tomeka
- Sukuraman Anila
- Summerfield Anna
- Summers Charlotte
- Sundaram Radha
- Sundaran Dhinesh
- Sunkara Krishna
- Surti Zuhra
- Sutherland Helen
- Sutherland Sara-Beth
- Sutterlin Laetitia
- Sutton Joanne
- Sutu Mihaela
- Sven?ek Franc
- Svit?kar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szawarski Piotr
- Tai Charlotte
- Tait Jennifer
- Talia Nadine
- Tallott Mandy
- Tamm Tina
- Tamme Kadri
- Taqdees Huda
- Tarr Esther
- Tate Margaret
- Tatham Kate
- Tavares Silvia
- Taylor Holly
- Taylor Melanie
- Taylor Sian
- Tee Ameila
- Templeton Maie
- Teo Hoon
- Terrill Lenae
- The Stephanie
- Thedinga Karen
- Thomas Amy
- Thomas Ashly
- Thomas Emma
- Thomas Helen
- Thomas Matt
- Thomas Vicky
- Thompson Patricia
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tirot Patrice
- Tlayjeh Haytham
- Toffalo Sue
- Tolppa Timo
- Tomasi Enrico
- Tomlinson Helen
- Tong Steve
- Tong Steven
- Tony Kiran
- Totzke Juliane
- Touma Omar
- Towns Miriam
- Trapani Tony
- Trask Kara
- Traverse Eleanor
- Trickey Jemma
- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
- Troeman Darren
- Trues Estefania
- Truman Nicholas
- Tsakiridou Kyriaki
- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
- Tully Riona
- Tung Raymond
- Tupper-Carey Daryl
- Turgeon Alexis F.
- Turki Salah
- Turner Anne M.
- Turner Elizabeth
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- TV Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Ullmann Hannah
- Umrani Zulfiqar
- Unsworth Adam
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Villot Solenne
- Vilá Clara
- Vincent Rachel
- Virdee Satwinder
- Visentin Elisa
- Visser Yorik
- Vita Tina
- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
- Voza Gennaro
- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wijewardena Gayathri
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Human Rights
- Author
- Abudu Nancy G.
- Ajemian Ani E.
- Albrecht Lawrence G.
- Farbell Kristin
- Fiadjoe Yvonne
- Kaymar Stafford Nancy
- Kepner Adrienne
- Kretman Joshua
- Maffai Margaret
- Mandor Melissa
- Meier Eileen
- Minkowitz Tina
- Nanda Ved P.
- Palmer Erin Louise
- Peyser Roxane
- Power Vanessa Soriano
- Rana Rajat
- Rehoff Lars Adam
- Rutherford Bridget
- Sarkin Jeremy
- Shackleford Scott
- Shameen Shista
- Shields Leslie
- Singh Jasprett
- Stephens Alice Ann
- Vidiaev Anna
- Publication venue
- SMU Scholar
- Publication date
- 01/01/2008
- Field of study
Children of “A Dream Come True”: A Critical Content Analysis of the Representations of Transracial Chinese Adoption in Picturebooks
- Author
- Alba Tobella Mayans
- Amy E Traver
- Ann Anagnost
- Beatriz San Roman
- Claudia Nelson
- David M Smolin
- Dolores de Manual
- Dorothy L Hurley
- Eleana J Kim
- Elizabeth A Suter
- Gina Miranda Samuels
- Hani Morgan
- Heather Jacobson
- Hilary Janks
- James P Gee
- Jane Jeong Trenka
- Jay W Rojewski
- Jeffrey Riegel
- Jillian Powers
- John Stephens
- Karen D Pyke
- Karin Lesnik-Oberstein
- Kelly Jerome
- Lee A Hefferman
- Lydia Kokkola
- Macarena García González
- Maria Nikolajeva
- Mark C Jerng
- Martha Satz
- Michael Apple
- Nili Luo
- Paulo Freire
- Richard Tessler
- Rudine Sims Bishop
- Ruth Lin Meese
- Ruth McKoy Lowery
- Samantha L Wilson
- Tobias Hubinette
- Toby Alice Volkman
- Tony Xing Tan
- Walter R Fisher
- Xinran
- Y Diana Pan
- Young S Colen
- Yutang Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Asylum Policy in the European Union: An Examination of the Reception Conditions Directive and Housing Facilities for Asylum Seekers in Malta
- Author
- Alice Szczepanikov�
- Andreas Maurer
- Annaliza Borg
- B Temple
- Bobby Cameron
- Bobby Thomas Cameron
- Cathryn Costello
- Charlie Sammut
- Chris Rumford
- Christina Boswell
- Christopher Schwarz
- D Cimbaljevich
- D L Higgins
- Da Lomba
- De Haas
- Deborah Phillips
- Derek Lutterbeck
- Dominik Kalweit
- Dora Kostakopoulou
- Edward Connolly
- Elspeth Guild
- Ernek M Ucarer
- Europa
- Europa
- Ferenc K?szeg
- Fiona Texeire
- Fred Tanner
- Gabriela I Coman
- Gerald L Neuman
- Gil-Bazo
- Government
- G�ran Rystad
- Hans-Olaf Pieper
- Harold R Trendell
- J Katona-Apte
- James D Fry
- Jan Niessen
- Jeanine Hennis-Plasschaert
- Jeffrey Cole
- Jesuit Refugee Service -Malta
- Jesuit Refugee Service -Malta
- John Cordina
- Joseph M Sammut
- Karen Jacobsen
- Lapo Salucci
- Laura Huntoon
- Liisa H Malkki
- Liz Fekete
- Liza Schuster
- Luis Morago-Nicol�s
- M Haswell-Elkins
- Malta
- Margit Fauser
- Marie Seeberg
- Mariella Micallef
- Mary Ann Stephens
- Matthew Fouse
- Merrill Smith
- Michael Carabott
- Michael Freeman
- Michael Pugh
- Michael T Martin
- Migreurop
- Monde M�decins Du
- Morten Kjaerum
- Nicola Rogers
- Ophelia Field
- Oscar Schachter
- Peo Hansen
- Presidency Conclusions
- Robert G Burgress
- Ryan Dilley
- Sandra Lavenex
- Silja Klepp
- Simon Turner
- Simon Turner
- Stephen Castles
- Steve Peers
- Suvendrini Perera
- Terri Givens
- Timothy J Hatton
- Unhcr
- Vanessa Macdonald
- Vaughan Robinson
- W Deville
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Blood Pressure Loci Identified with a Gene-Centric Array
- Author
- Abecasis Gonçalo R
- Allione Alessandra
- Altshuler David
- Attwood Tony
- Bandinelli Stefania
- Barroso Inês
- Beckmann Jacques S
- Belz Stephanie
- Berglund Göran
- Bergman Richard N
- Bergmann Sven
- Bingham Sheila A
- Bochud Murielle
- Boehnke Michael
- Bonnycastle Lori L
- Bots Michiel L
- Braund Peter
- Brocheton Jessy
- Brown Morris
- Burton Paul R
- Cambien François
- Casas Juan-Pablo
- Caulfield Mark
- Chambers John C
- Chen Li
- Clarke Robert
- Coin Lachlan
- Collins Francis S
- Connell John M
- Cooper Jackie A
- Cooper Jason
- Crawford Gabriel J
- Crisp-Hihn Abi
- Cusi Daniele
- Davey Smith George
- Day Ian N M
- de Jong Paul E
- Delles Christian
- Deloukas Panos
- Devos Nabila
- Di Gregorio Alessandra
- Diemert Patrick
- Dobson Richard J
- Dominiczak Anna
- Drenos Fotios
- Döring Angela
- Dörr Marcus
- Eardman Jeanette
- Elliott Katherine S
- Elliott Paul
- Elosua Roberto
- Ernst Florian
- Eyheramendy Susana
- Farrall Martin
- Felix Stephan B
- Ferrucci Luigi
- Foad Nicola
- Forouhi Nita G
- Fowkes F Gerald
- Franke Lude
- Franzosi Maria Grazia
- Freimer Nelson B
- Galan Pilar
- Gateva Vesela
- Gaunt Tom R
- Gieger Christian
- Glorioso Nicola
- Godefroy Tiphaine
- Goel Anuj
- Goodall Alison H
- Gracey Jay
- Gray Emma
- Grobbee Diederick E
- Groop Leif
- Guarrera Simonetta
- Gut Ivo G
- Gwilliams Rhian
- Hadley David
- Hamsten Anders
- Hardy Rebecca
- Hartikainen Anna-Liisa
- Hastie Claire E
- Heath Simon C
- Hedner Thomas
- Heimer Susanne
- Hengstenberg Christian
- Hercberg Serge
- Hingorani Aroon D
- Holmes Michael V
- Homuth Georg
- Howard Philip J
- Hua Jing
- Humphries Steve E
- Illig Thomas
- Jackson Anne U
- Jarvelin Marjo-Riitta
- Jeunemaitre Xavier
- Johnson Toby
- Jolley Jennifer
- Jousilahti Pekka
- Juhanson Peeter
- Kathiresan Sekar
- Khaw Kay-Tee
- Kivimaki Mika
- Kooner Jaspal S
- Krishnan Unni
- Kuh Diana
- Kumari Meena
- Kuusisto Johanna
- Laakso Markku
- Laan Maris
- Lakatta Edward G
- Lathrop G Mark
- Lathrop Mark
- Lawlor Debbie A
- Lee Wai K
- Levinsson Anna
- Liljedahl Ulrika
- Lim Noha
- Lloyd-Jones Heather
- Loos Ruth J F
- Lorbeer Roberto
- Luan Jian'an
- Luben Robert N
- Lucas Gavin
- Lugauer Ingrid
- Lundmark Per
- Maouche Seraya
- Marrugat Jaume
- Matullo Giuseppe
- McArdle Wendy L
- McCarthy Mark I
- Mein Charles A
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Mohlke Karen L
- Montalescot Gilles
- Moore Jasbir S
- Mooser Vincent
- Morken Mario A
- Morris Richard W
- Muir David
- Munroe Patricia B
- Murray Elizabeth
- Najjar Samer S
- Navis Gerjan
- Nelson Chris P
- Nelson Christopher P
- Neudert Jessica
- Neuvrith Hani
- Newhouse Stephen J
- Newton-Cheh Christopher
- Niblett David
- Nilsson Peter
- Numans Mattijs E
- Nyberg Fredrik
- O'Brien Eoin T
- O'Donnell Christopher J
- O'Leary Karen
- Onipinla Abiodun
- Onland-Moret N Charlotte
- OReilly Paul F
- Org Elin
- Orho Marju
- Ouwehand Willem H
- Padmanabhan Sandosh
- Palmen Jutta
- Panico Salvatore
- Papadakis Konstantinos
- Paterson Andrew D
- Peden John F
- Peltonen Leena
- Perola Markus
- Pfeufer Arne
- Plouin Pierre-François
- Polidoro Silvia
- Pollard Helen
- Poulter Neil R
- Pouta Anneli
- Proust Carole
- Putku Margus
- Rankin Angela
- Reffelmann Thorsten
- Rendon Augusto
- Rettig Rainer
- Ricceri Fulvio
- Rice Catherine M
- Roberts Robert
- Romanazzi Valeria
- Rosengren Annika
- Sacerdote Carlotta
- Sager Hendrik B
- Salomaa Veikko
- Salvi Erika
- Samani Nilesh J
- Sambrook Jennifer
- Sandhu Manjinder S
- Sanna Serena
- Scheet Paul
- Schlessinger David
- Schmitz Gerd
- Scholz Michael
- Schroeder Laura
- Schunkert Heribert
- Schwartz Stephen M
- Scott Laura J
- Scuteri Angelo
- Seedorf Udo
- Sever Peter
- Shah Sonia
- Shah Tina
- Shaw-Hawkins Sue
- Shields Denis C
- Siscovick David S
- Snieder Harold
- Song Kijoung
- Soranzo Nicole
- Spector Tim D
- Staessen Jan A
- Stanton Alice V
- Stephens Jonathan
- Stewart Alexandre F R
- Strachan David P
- Stringham Heather M
- Stucchi Andrea
- Subirana Isaac
- Syv Christine
- Syvannen Ann-Christine
- Sõber Siim
- Talmud Philippa J
- Tanaka Toshiko
- Tennstedt Stefanie
- Teumer Alexander
- Thelle Dag S
- Thom Simon
- Tichet Jean
- Tobin Martin D
- Tognoni Giovanni
- Tomaszewski Maciej
- Tuomilehto Jaakko
- Tzoulaki Ioanna
- Uda Manuela
- Uiterwaal Cuno S
- Valle Timo T
- van der Harst Pim
- van der Schouw Yvonne T
- van Gilst Wiek H
- Veldre Gudrun
- Viigimaa Margus
- Vineis Paolo
- Voight Benjamin F
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber Gerard
- Wahlstrand Björn
- Wain Louise V
- Wallace Chris
- Wannamethee Sasiwarang G
- Wareham Nicholas J
- Waterworth Dawn M
- Watkins Hugh
- Webster John
- Wellcome Trust Case Control Consortium I-chip For Psoriasis
- Wells George A
- Westra Harm-Jan
- Whincup Peter H
- Whittaker John
- Wichmann H Erich
- Willer Cristen J
- Williams Frances M
- Wolfs Marcel G M
- Wong Andrew
- Yuan Xin
- Zeggini Eleftheria
- Zeleneka Diana
- Zhai Guangju
- Zhang Feng
- Zhang Yun
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56 × 10−7 study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r2 = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 × 10−7 at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies