Strategic placement of automated external defibrillators (AEDs) for cardiac arrests in public locations and private residences

Aim: The aim of our study was to determine whether businesses can be identified that rank highly for their potential to improve coverage of out-of-hospital cardiac arrests (OHCAs) by automated external defibrillators (AEDs), both in public locations and private residences. Methods: The cohort comprised 10,422 non-traumatic OHCAs from 2014 to 2020 in Perth, Western Australia. We ranked 115 business brands (across 5,006 facilities) for their potential to supplement coverage by the 3,068 registered public-access AEDs in Perth, while accounting for AED access hours. Results: Registered public-access AEDs provided 100 m coverage of 23% of public-location arrests, and 4% of arrests in private residences. Of the 10 business brands ranked highest for increasing the coverage of public OHCAs, six brands were ranked in the top 10 for increased coverage of OHCAs in private residences. A public phone brand stood out clearly as the highest-ranked of all brands, with more than double the coverage-increase of the second-ranked brand. If all 115 business brands hosted AEDs with 24–7 access, 57% of OHCAs would remain without 100 m coverage for public arrests, and 92% without 100 m coverage for arrests in private residences. Conclusion: Many businesses that ranked highly for increased coverage of arrests in public locations also rank well for increasing coverage of arrests in private residences. However, even if the business landscape was highly saturated with AEDs, large gaps in coverage of OHCAs would remain, highlighting the importance of considering other modes of AED delivery in metropolitan landscapes

Fall from standing height, or greater, and mortality among ambulance-transported patients with major trauma from falls

Introduction: This study describes the relationship between falls from standing height, or greater, and mortality in ambulance-transported patients with major trauma from falls. Methods: Road ambulance records from 1 January 2013 to 31 December 2016 were linked with WA State Trauma Registry records to identify ambulance-transported falls patients with major trauma. Results: Of the patients who fell from standing level, 114/460 (25%) died within 30 days, compared with 47/222 (21%) who fell from height (p=0.64). Conclusion: Mortality is relatively high, and fall height is not associated with 30-day survival, among ambulance-transported patients with major trauma in metropolitan Perth, Western Australia

Carcinogenesis in Prostate Cancer: The role of Long Non-Coding RNAs

LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway

High-Energy X-ray Imaging of the Pulsar Wind Nebula MSH~15-52: Constraints on Particle Acceleration and Transport

We present the first images of the pulsar wind nebula (PWN) MSH 15-52 in the hard X-ray band (>8 keV), as measured with the Nuclear Spectroscopic Telescope Array (NuSTAR). Overall, the morphology of the PWN as measured by NuSTAR in the 3-7 keV band is similar to that seen in Chandra high-resolution imaging. However, the spatial extent decreases with energy, which we attribute to synchrotron energy losses as the particles move away from the shock. The hard-band maps show a relative deficit of counts in the northern region towards the RCW 89 thermal remnant, with significant asymmetry. We find that the integrated PWN spectra measured with NuSTAR and Chandra suggest that there is a spectral break at 6 keV which may be explained by a break in the synchrotron-emitting electron distribution at ~200 TeV and/or imperfect cross calibration. We also measure spatially resolved spectra, showing that the spectrum of the PWN softens away from the central pulsar B1509-58, and that there exists a roughly sinusoidal variation of spectral hardness in the azimuthal direction. We discuss the results using particle flow models. We find non-monotonic structure in the variation with distance of spectral hardness within 50" of the pulsar moving in the jet direction, which may imply particle and magnetic-field compression by magnetic hoop stress as previously suggested for this source. We also present 2-D maps of spectral parameters and find an interesting shell-like structure in the NH map. We discuss possible origins of the shell-like structure and their implications.Comment: 15 pages, 9 figures, accepted for publication in Ap

The Hard X-Ray View of the Young Supernova Remnant G1.9+0.3

NuSTAR observed G1.9+0.3, the youngest known supernova remnant in the Milky Way, for 350 ks and detected emission up to $\sim$30 keV. The remnant's X-ray morphology does not change significantly across the energy range from 3 to 20 keV. A combined fit between NuSTAR and CHANDRA shows that the spectrum steepens with energy. The spectral shape can be well fitted with synchrotron emission from a power-law electron energy distribution with an exponential cutoff with no additional features. It can also be described by a purely phenomenological model such as a broken power-law or a power-law with an exponential cutoff, though these descriptions lack physical motivation. Using a fixed radio flux at 1 GHz of 1.17 Jy for the synchrotron model, we get a column density of N$_{\rm H}$ = $(7.23\pm0.07) \times 10^{22}$ cm$^{-2}$, a spectral index of $\alpha=0.633\pm0.003$, and a roll-off frequency of $\nu_{\rm rolloff}=(3.07\pm0.18) \times 10^{17}$ Hz. This can be explained by particle acceleration, to a maximum energy set by the finite remnant age, in a magnetic field of about 10 $\mu$G, for which our roll-off implies a maximum energy of about 100 TeV for both electrons and ions. Much higher magnetic-field strengths would produce an electron spectrum that was cut off by radiative losses, giving a much higher roll-off frequency that is independent of magnetic-field strength. In this case, ions could be accelerated to much higher energies. A search for $^{44}$Ti emission in the 67.9 keV line results in an upper limit of $1.5 \times 10^{-5}$ $\,\mathrm{ph}\,\mathrm{cm}^{-2}\,\mathrm{s}^{-1}$ assuming a line width of 4.0 keV (1 sigma).Comment: 9 pages, 6 figures, accepted Ap

A Spatially Resolved Study of the Synchrotron Emission and Titanium in Tycho's Supernova Remnant with NuSTAR

We report results from deep observations (~750 ks) of Tycho's supernova remnant (SNR) with NuSTAR. Using these data, we produce narrow-band images over several energy bands to identify the regions producing the hardest X-rays and to search for radioactive decay line emission from 44Ti. We find that the hardest (>10 keV) X-rays are concentrated in the southwest of Tycho, where recent Chandra observations have revealed high emissivity "stripes" associated with particles accelerated to the knee of the cosmic-ray spectrum. We do not find evidence of 44Ti, and we set limits on its presence and distribution within the SNR. These limits correspond to a upper-limit 44Ti mass of M44 < 2.4x10^-4 M_sun for a distance of 2.3 kpc. We perform spatially resolved spectroscopic analysis of sixty-six regions across Tycho. We map the best-fit rolloff frequency of the hard X-ray spectra, and we compare these results to measurements of the shock expansion and ambient density. We find that the highest energy electrons are accelerated at the lowest densities and in the fastest shocks, with a steep dependence of the roll-off frequency with shock velocity. Such a dependence is predicted by models where the maximum energy of accelerated electrons is limited by the age of the SNR rather than by synchrotron losses, but this scenario requires far lower magnetic field strengths than those derived from observations in Tycho. One way to reconcile these discrepant findings is through shock obliquity effects, and future observational work is necessary to explore the role of obliquity in the particle acceleration process.Comment: 12 pages, 12 figures, ApJ in pres

NuSTAR study of Hard X-Ray Morphology and Spectroscopy of PWN G21.5-0.9

We present NuSTAR high energy X-ray observations of the pulsar wind nebula (PWN)/supernova remnant G21.5-0.9. We detect integrated emission from the nebula up to ~40 keV, and resolve individual spatial features over a broad X-ray band for the first time. The morphology seen by NuSTAR agrees well with that seen by XMM-Newton and Chandra below 10 keV. At high energies NuSTAR clearly detects non-thermal emission up to ~20 keV that extends along the eastern and northern rim of the supernova shell. The broadband images clearly demonstrate that X-ray emission from the North Spur and Eastern Limb results predominantly from non-thermal processes. We detect a break in the spatially integrated X-ray spectrum at ~9 keV that cannot be reproduced by current SED models, implying either a more complex electron injection spectrum or an additional process such as diffusion compared to what has been considered in previous work. We use spatially resolved maps to derive an energy-dependent cooling length scale, $L(E) \propto E^{m}$ with $m = -0.21 \pm 0.01$. We find this to be inconsistent with the model for the morphological evolution with energy described by Kennel & Coroniti (1984). This value, along with the observed steepening in power-law index between radio and X-ray, can be quantitatively explained as an energy-loss spectral break in the simple scaling model of Reynolds (2009), assuming particle advection dominates over diffusion. This interpretation requires a substantial departure from spherical magnetohydrodynamic (MHD), magnetic-flux-conserving outflow, most plausibly in the form of turbulent magnetic-field amplification.Comment: 13 pages, 8 figures, 1 table, Accepted for publication in the Astrophysical Journa

Locating the most energetic electrons in Cassiopeia A

We present deep ($>$2.4 Ms) observations of the Cassiopeia A supernova remnant with {\it NuSTAR}, which operates in the 3--79 keV bandpass and is the first instrument capable of spatially resolving the remnant above 15 keV. We find that the emission is not entirely dominated by the forward shock nor by a smooth "bright ring" at the reverse shock. Instead we find that the $>$15 keV emission is dominated by knots near the center of the remnant and dimmer filaments near the remnant's outer rim. These regions are fit with unbroken power-laws in the 15--50 keV bandpass, though the central knots have a steeper ($\Gamma \sim -3.35$) spectrum than the outer filaments ($\Gamma \sim -3.06$). We argue this difference implies that the central knots are located in the 3-D interior of the remnant rather than at the outer rim of the remnant and seen in the center due to projection effects. The morphology of $>$15 keV emission does not follow that of the radio emission nor that of the low energy ($<$12 keV) X-rays, leaving the origin of the $>$15 keV emission as an open mystery. Even at the forward shock front we find less steepening of the spectrum than expected from an exponentially cut off electron distribution with a single cutoff energy. Finally, we find that the GeV emission is not associated with the bright features in the {\it NuSTAR} band while the TeV emission may be, suggesting that both hadronic and leptonic emission mechanisms may be at work.Comment: 12 pages, 11 figures, accepted for publication in Ap

Plans for the LIGO-TAMA Joint Search for Gravitational Wave Bursts

We describe the plans for a joint search for unmodelled gravitational wave bursts being carried out by the LIGO and TAMA collaborations using data collected during February-April 2003. We take a conservative approach to detection, requiring candidate gravitational wave bursts to be seen in coincidence by all four interferometers. We focus on some of the complications of performing this coincidence analysis, in particular the effects of the different alignments and noise spectra of the interferometers.Comment: Proceedings of the 8th Gravitational Wave Data Analysis Workshop, Milwaukee, WI, USA. 10 pages, 3 figures, documentclass ``iopart'