Effect of 2-N-mono- and 2-N-diethylaminoethanol on normal and choline-deficient rats

In rats, the acute oral LD50 value of neutralized 2-N-monoethylaminoethanol (MEAE) was found to be 1.0 (0.68-1.35) g/kg. The acute oral toxicity of MEAE, but not that of 2-N-diethylaminoethanol (DEAE) could be largely reversed by simultaneous or subsequent ingestion of choline. MEAE partially prevented the development of fatty liver in choline-deficient rats. No reversal of depressed growth rate was noted in choline-deficient animals whose diets were supplemented with either MEAE or DEAE.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33393/1/0000792.pd

Double‐blind placebo‐controlled multicenter phase II trial to evaluate D‐methionine in preventing/reducing oral mucositis induced by radiation and chemotherapy for head and neck cancer

BackgroundThe purpose of this study was to test if oral D‐methionine (D‐met) reduced mucositis during chemoradiotherapy.MethodsWe conducted a placebo‐controlled double‐blind randomized phase II trial of D‐met (100 mg/kg p.o. b.i.d.) testing the rate of severe (grades 3‐4) mucositis.ResultsSixty patients were randomized. Grade 2 + oral pain was higher with placebo (79% vs 45%; P = .0165), whereas grade 2 + body odor was greater with D‐met (3% vs 41%; P = .0015). Mucositis was decreased with D‐met by the physician (World Health Organization [WHO], P = .007; Radiation Therapy Oncology Group [RTOG], P = .009) and patient functional scales (RTOG, P = .0023). The primary end point of grades 3 to 4 mucositis on the composite scale demonstrated a decrease with D‐met (48% vs 24%; P = .058), which was borderline in significance. A planned secondary analysis of a semiquantitative scoring system noted decreased oral ulceration (2.2 vs 1.5; P = .023) and erythema (1.6 vs 1.1; P = .048) with D‐met.ConclusionAlthough not meeting the primary end point, results of multiple assessments suggest that D‐met decreased mucositis.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144699/1/hed25115.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144699/2/hed25115_am.pd

TWO NEW SPECIES OF CHIGGER MITES (ACARI: TROMBICULIDAE) CLOSE TO NEOTROMBICULA MINUTA, APPLICATION OF NONLINEAR MULTIVARIATE STATISTICS

Two new species of chigger mites, Neotrombicula urartensis sp. n. from rodents and birds and N. kubanensis sp. n. from rodents, are described from Caucasus. Morphological discontinuity of Neotrombicula urartensis and N. scrupulosa was demonstrated using logistic regression analysis

Metabolism of Isobarturic Acid in Adult Pregnant, Growing Dogs and Humans

Abstract not availabl