160 research outputs found
Contagion at the interbank market with stochastic LGD
This paper investigates contagion at the German interbank market under the assumption of a stochastic loss given default (LGD). We combine a unique data set about the LGD of interbank loans with data about interbank exposures. We find that the frequency distribution of the LGD is u-shaped. Under the assumption of a stochastic LGD, simulation results show a more fragile banking system than under the assumption of a constant LGD. There are three types of banks concerning their tendency to trigger contagion: banks with strongly varying impact, banks whose impact is relatively constant, and banks with no direct impact. --interbank market,contagion,stochastic LGD
Multidisciplinary perspectives on living marine resources in the Arctic
Many areas in the Arctic are vulnerable to the impacts of climate change. We observe large-scale effects on physical, biological, economic and social parameters, including ice cover, species distributions, economic activity and regional governance frameworks. Arctic living marine resources are affected in various ways. A holistic understanding of these effects requires a multidisciplinary enterprise. We synthesize relevant research, from oceanography and ecology, via economics, to political science and international law. We find that multidisciplinary research can enhance our understanding and promote new questions and issues relating to impacts and outcomes of climate change in the Arctic. Such issues include recent insights on changing spawning migrations of the North-east Arctic cod stock that necessitates revisions of socioeconomic estimates of ecosystem wealth in the Barents Sea, better integrated prediction systems that require increased cooperation between experts on climate prediction and ecosystem modelling, and institutional complexities of Arctic governance that require enhanced coordination.publishedVersio
Association between TAS2R38 gene polymorphisms and colorectal cancer risk
Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (ORâ=â1.28, 95% CI 0.99-1.67; P(value)â=â0.058) and statistically significant in the German population (ORâ=â1.36, 95% CI 1.06-1.75; P(value)â=â0.016) and in the joint analysis (ORâ=â1.34, 95% CI 1.12-1.61; P(value)â=â0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin
Genetic polymorphisms in the cag pathogenicity island of Helicobacter pylori and risk of stomach cancer and highâgrade premalignant gastric lesions
AbstractHelicobacter pylori (Hp) infects the stomach of about half of the human population and is strongly associated with the risk of gastric cancer (GC) and its premalignant precursors. The cag pathogenicity island (cagPAI) is a region of the Hp genome encoding for key molecular machinery involved in the infection process. Following a sequencing study, we selected 50 genetic polymorphisms located in seven cagPAI genes and tested their associations with the risk of advanced gastric premalignant lesions and GC in 1220 subjects from various Latin American populations showing the whole spectrum of phenotypes from gastritis to GC. We found that three polymorphisms of cagA are associated with the risk of advanced gastric premalignant lesions (incomplete intestinal metaplasia [ie, Type 2 and 3] or dysplasia), and that six polymorphisms located in cagA, cagL and cagI were associated with risk of GC. When corrected for multiple testing none of the associations were statistically significant. However, scores built by integrating the individual polymorphisms were significantly associated with the risk of advanced gastric premalignant lesions and GC. These results have the potential of establishing markers for risk stratification in the general population, in view of targeting Hp eradication to highârisk population groups
Risk assessment on import of Australian redclaw crayfish to Norway. Opinion of the Panel on Animal Health and Welfare of the Norwegian Scientific Committee for Food Safety
Source at https://vkm.no/english/riskassessments/allpublications/assessmentofriskstoanimalhealthandbiodiversityfromimportandfarmingofaustralianredclawcrayfish.4.2375207615dac0245aee2789.html.Main message: It seems unlikely that the Australian red claw clayfish will establish reproductive populations under Norwegian climate conditions, but hitchhiker organisms and infectious agents could potentially follow the import, and unless managed, may pose risks to biodiversity and aquatic animal health. This is the conclusion in a risk assessment from the Norwegian Scientific Committee for Food Safety (VKM)
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