Intrapericardial Giant Lipoma Displacing the Heart

Despite their benign character, intrapericardial lipomas can cause life-threatening complications by rapid growth. This paper presents a case of an intrapericardial lipoma in an almost asymptomatic 41-year-old female patient only suffering from mild dyspnoea on exertion. The tumour was found incidentally by chest X-ray. Echocardiographic examination and a CT scan of the thorax revealed a 16 × 14 × 12 cm lipomatous tumour mass highly suspective of a lipoma. Histological examination of excised tumour specimens confirmed the diagnosis of a lipoma. The patient is currently asymptomatic and has not presented with evidence of recurrence at the 6-month followup

On improving the iterative convergence properties of an implicit approximate-factorization finite difference algorithm

The iterative convergence properties of an approximate-factorization implicit finite-difference algorithm are analyzed both theoretically and numerically. Modifications to the base algorithm were made to remove the inconsistency in the original implementation of artificial dissipation. In this way, the steady-state solution became independent of the time-step, and much larger time-steps can be used stably. To accelerate the iterative convergence, large time-steps and a cyclic sequence of time-steps were used. For a model transonic flow problem governed by the Euler equations, convergence was achieved with 10 times fewer time-steps using the modified differencing scheme. A particular form of instability due to variable coefficients is also analyzed

On applications of chimera grid schemes to store separation

A finite difference scheme which uses multiple overset meshes to simulate the aerodynamics of aircraft/store interaction and store separation is described. In this chimera, or multiple mesh, scheme, a complex configuration is mapped using a major grid about the main component of the configuration, and minor overset meshes are used to map each additional component such as a store. As a first step in modeling the aerodynamics of store separation, two dimensional inviscid flow calculations were carried out in which one of the minor meshes is allowed to move with respect to the major grid. Solutions of calibrated two dimensional problems indicate that allowing one mesh to move with respect to another does not adversely affect the time accuracy of an unsteady solution. Steady, inviscid three dimensional computations demonstrate the capability to simulate complex configurations, including closely packed multiple bodies

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. Here we show that the Forkhead transcription factors FoxK1 and FoxK2 are also downstream targets of insulin action, but that following insulin stimulation, they translocate from the cytoplasm to nucleus, reciprocal to the translocation of FoxO1. FoxK1/FoxK2 translocation to the nucleus is dependent on the Akt-mTOR pathway, while its localization to the cytoplasm in the basal state is dependent on GSK3. Knockdown of FoxK1 and FoxK2 in liver cells results in upregulation of genes related to apoptosis and down-regulation of genes involved in cell cycle and lipid metabolism. This is associated with decreased cell proliferation and altered mitochondrial fatty acid metabolism. Thus, FoxK1/K2 are reciprocally regulated to FoxO1 following insulin stimulation and play a critical role in the control of apoptosis, metabolism and mitochondrial function

Exploring functional regression for dynamic modeling of shallow landslides in South Tyrol, Italy

Shallow landslides are ubiquitous hazards in mountainous regions worldwide that arise from an interplay of static predisposing factors and dynamic preparatory and triggering conditions. Modeling shallow landslides at regional scales has leveraged data-driven approaches to separately investigate purely spatial landslide susceptibility and temporally varying conditions. Yet, the joint assessment of shallow landslides in space and time using data-driven methods remains challenging. Furthermore, dynamic factors have been typically included in data-driven landslide models as scalar predictors by employing aggregated descriptors over time (e.g., mean, maximum, or total precipitation over a defined time window), where many choices are possible for the considered time scales and aggregation operators. Therefore, incorporating the time-varying behavior of dynamic factors remains difficult.This study addresses these challenges by exploring Functional Generalized Additive Models (FGAMs) to predict the occurrence of shallow landslides in space and time within the Italian province of South Tyrol (7,400 km²). In contrast to conventional techniques, we test the benefits of using functional predictors to describe dynamic factors (e.g., precipitation and temperature) leading to landslide events. In other words, we evaluate dynamic factors as collections of measurements over time (i.e., time series). To do so, our approach uses a binomial FGAM to analyze the statistical associations between the static factors (scalar predictors), the dynamic weather conditions prior to a potential landslide occurrence (functional predictors), and the occurrence of shallow landslides in space and time.Potential outcomes of this novel approach show an overview of the added value of using functional predictors for space and time shallow landslide modeling. These research findings are positioned within the context of the PROSLIDE project, which has received financial support from the Research Südtirol/Alto Adige 2019 research program of the Autonomous Province of Bozen/Bolzano – Südtirol/Alto Adige

Patient compliance with clinical follow-up after total joint arthroplasty

Patient compliance with clinical follow-up after total joint arthroplast

Ultrafast control of strong light-matter coupling

We dynamically modulate strong light–matter coupling in a GaAs/AlGaAs microcavity using intense ultrashort laser pulses tuned below the interband exciton energy, which induce a transient Stark shift of the cavity polaritons. For 225-fs pulses, shorter than the cavity Rabi cycle period of 1000 fs, this shift decouples excitons and cavity photons for the duration of the pulse, interrupting the periodic energy exchange between photonic and electronic states. For 1500-fs pulses, longer than the Rabi cycle period, however, the Stark shift does not affect the strong coupling. The two regimes are marked by distinctly different line shapes in ultrafast reflectivity measurements—regardless of the Stark field intensity. The crossover marks the transition from adiabatic to diabatic switching of strong light–matter coupling