INHALATION TOXICITY OF ZIRCONIUM COMPOUNDS. I. SHORT-TERM STUDIES

A total of 270 animals of 5 species was exposed by inhalation to compounds of zirconium for 6 hours per day, 5 days per week. One group of animals was exposed to ZrO{sub 2} at an atmospheric concentration of 75 mg. Zr/m{sup 3} for 30 days; another, to 11 mg. Zr/m{sup 3} for 60 days. A third group was exposed to a mist of ZrCl{sub 4} at a level of 6 mg. Zr/m{sup 3} for 60 days. Zirconium oxide produced no significant changes in mortality, growth rate, blood nonprotein nitrogen or fibrinogen, urinary protein, hematological values or histological structure. Zirconium tetrachloride at 6 mg. Zr/m{sup 3} gave questionable changes in blood hemoglobin concentration and red cell counts of dogs and a slight increase in mortality of rats and guinea pigs. Inhaled zirconium compounds deposited primarily in the lung and pulmonary lymph node, with a fraction of a per cent in the bone and considerably less in the soft tissues. (auth

The inhalation toxicity of indium sesquioxide in the rat /

"Date completed: 2/10/61; Date of issue: 5/10/61.""Contract W-7401-eng-49 between the U.S. Atomic Energy Commission and the University of Rochester, administered by the Department of Radiation Biology of the School of Medicine and Dentistry.""Unclassified.""Biology and Medicine, TID-4500 (15th ed.).""UR-590."Includes bibliographical references (page 30).Mode of access: Internet

Inhalation toxicity of zirconium compounds : I. Short term studies /

"Date Completed: 7/9/56; Date of Issue: 7/31/56."Account of work sponsored by a contract between the U.S. Atomic Energy Commission and the University of Rochester, and administered by the Department of Radiation Biology of the School of Medicine and Dentistry of the University."UR 460."Includes bibliographical references.Mode of access: Internet

Acute toxicity of inhaled beryllium.

"Health and Biology; Date of Report: 7/17/51."Includes bibliographical references (pages 38-39).Mode of access: Internet

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press