156 research outputs found

    The puzzling reliability of the Force Concept Inventory

    Get PDF
    The Force Concept Inventory (FCI) has influenced the development of many research-based pedagogies. However, no data exists on the FCI’s internal consistency or test-retest reliability. The FCI was administered twice to one hundred students during the first week of classes in an electricity and magnetism course with no review of mechanics between test administrations. High Kuder–Richardson reliability coefficient values, which estimate the average correlation of scores obtained on all possible halves of the test, suggest strong internal consistency. However, 31% of the responses changed from test to retest, suggesting weak reliability for individual questions. A chi-square analysis shows that change in responses was neither consistent nor completely random. The puzzling conclusion is that although individual FCI responses are not reliable, the FCI total score is highly reliable

    Cooperative and Antagonistic Contributions of Two Heterochromatin Proteins to Transcriptional Regulation of the Drosophila Sex Determination Decision

    Get PDF
    Eukaryotic nuclei contain regions of differentially staining chromatin (heterochromatin), which remain condensed throughout the cell cycle and are largely transcriptionally silent. RNAi knockdown of the highly conserved heterochromatin protein HP1 in Drosophila was previously shown to preferentially reduce male viability. Here we report a similar phenotype for the telomeric partner of HP1, HOAP, and roles for both proteins in regulating the Drosophila sex determination pathway. Specifically, these proteins regulate the critical decision in this pathway, firing of the establishment promoter of the masterswitch gene, Sex-lethal (Sxl). Female-specific activation of this promoter, SxlPe, is essential to females, as it provides SXL protein to initiate the productive female-specific splicing of later Sxl transcripts, which are transcribed from the maintenance promoter (SxlPm) in both sexes. HOAP mutants show inappropriate SxlPe firing in males and the concomitant inappropriate splicing of SxlPm-derived transcripts, while females show premature firing of SxlPe. HP1 mutants, by contrast, display SxlPm splicing defects in both sexes. Chromatin immunoprecipitation assays show both proteins are associated with SxlPe sequences. In embryos from HP1 mutant mothers and Sxl mutant fathers, female viability and RNA polymerase II recruitment to SxlPe are severely compromised. Our genetic and biochemical assays indicate a repressing activity for HOAP and both activating and repressing roles for HP1 at SxlPe

    Cultures, colleges and the development of ideas about teaching in English Further Education

    Get PDF
    This article examines the development of new teachers’ practice and conceptions of teaching in English further education (FE). Drawing upon data from observations and interviews involving both trainee and serving teachers at a large FE college, it discusses and applies a restricted conceptualisation of culture to investigate the influence of local cultures on new teachers. The paper concludes that while experiences of sections of teachers within the institution may diverge, they share much greater commonality. Even in the few instances where distinctive and sustainable local cultures existed these did not necessarily lead to distinctive teaching practices, suggesting that the most powerful influences on teaching in FE may derive from dominant ideas in society, not from local workplace settings. The paper argues that research that concentrates on the local, such as the Transforming Learning Cultures in Further Education project, risks understating the significance of wider cultural influences on learning, in this case on learning to teach in FE

    Multinomial Sequence Based Estimation Using Contiguous Subsequences of Length Three

    No full text
    The Maximum Likelihood (ML) and Bayesian estimation paradigms work within the model that the data, from which the parameters are to be estimated, is treated as a set rather than as a sequence. The pioneering paper that dealt with the field of sequence-based estimation [2] involved utilizing both the information in the observations and in their sequence of appearance. The results of [2] introduced the concepts of Sequence Based Estimation (SBE) for the Binomial distribution, where the authors derived the corresponding MLE results when the samples are taken two-at-a-time, and then extended these for the cases when they are processed three-at-a-time, four-at-a-time etc. These results were generalized for the multinomial “two-at-a-time” scenario in [3]. This paper (This paper is dedicated to the memory of Dr. Mohamed Kamel, who was a close friend of the first author.) now further generalizes the results found in [3] for the multinomial case and for subsequences of length 3. The strategy used in [3] (and also here) involves a novel phenomenon called “Occlusion” that has not been reported in the field of estimation. The phenomenon can be described as follows: By occluding (hiding or concealing) certain observations, we map the estimation problem onto a lower-dimensional space, i.e., onto a binomial space. Once these occluded SBEs have been computed, the overall Multinomial SBE (MSBE) can be obtained by combining these lower-dimensional estimates. In each case, we formally prove and experimentally demonstrate the convergence of the corresponding estimates
    corecore