Synthese du squelette de mitomycines

SIGLEINIST T 74164 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

A SAAS business from scratch: The discovery, validation and launch of a citizen development SAAS platform within an incubator ecosystem

This report validates the business idea of Cloudr, a tool that converts spreadsheets into web applications. For this, the challenges of spreadsheets within organizations and their current solutions are portrayed, after which the feasibility of the proposed business concept is analyzed. Insights from literature review, qualitative research (interviews with business users, IT and potential partners) and quantitative research (a survey) are provided. Moreover, enlightenment is provided onto the technological, strategic and financial feasibility. Current literature reinforces the challenges of spreadsheets within organizations such as version control, data governance and the management of shadow IT. Current low-code platforms are not sucient to resolve these challenges, as many business users consider them to be either too complex, or too limited in functionality. The current competitors within the spreadsheet conversion landscape have not successfully exploited all opportunities at present, leaving room for a solution such as Cloudr. Furthermore, both the survey and interviews with business users confirm the diculty of creating web applications, whereas the IT department understands the risks of shadow IT practices and the need for data governance. Initial conversations with strategic partners have even highlighted their interest to collaborate. Therefore, we see an opportunity for the proposed business idea within the low-code market: a tool that converts a spreadsheet into a Microsoft Power App, both as an exact copy or through altering the layout using a layout builder. The technological feasibility of this concept has been validated successfully through the development of a functional proof of concept in which all core functionalities are included. This proof of concept is suciently sophisticated to be used as a demo pitch towards initial prospects. Technicalities that are not yet implemented, are validated through conversations with field experts. No major technological complications are expected, although it will be dicult to opt for a true SaaS approach as introducing customer stickiness is not evident when making use of third-party platforms as a conversion tool. A strategic analysis points out the achievability of the business idea from a strategic point of view. There is a reasonable amount of threats, some of which can be alleviated by leveraging the Cronos ecosystem. An example of a significant threat is the bargaining power that Microsoft has as a supplier of Power Platform. A market size analysis indicates that a sizeable market is available. Lastly, the financial forecasts are promising, with an estimated revenue of 2.3 million euro and a net profit of about 500,000 euro after-tax in year five. For this, a total investment of 200,000 euro besides the injected start-up capital is required within the first year. Given that the feasibility of the business concept has been validated successfully until now, our recommendation is to continue the development of Cloud and further investigate the interest of the market. This is why we have set up a meeting with a potential first customer after our project, during which we will pitch the business concept of Cloudr.Cronos Grou

OCT study of fellow eyes of macular holes

The aim of this study was to examine the vitreomacular interface in symptom-free fellow eyes of macular holes using optical coherence tomography (OCT) to add information to the pathogenesis of macular holes and to refine prognostic factors for bilateral involvement. Sixty-six patients with a full thickness macular hole in one eye and a symptom-free fellow eye were included in the study between 01/98-05/99. The finding on OCT that a perifoveal vitreous detachment can result in a foveal cyst and subsequently a macular hole confirms the theory of Gass of vitreous traction. Symptom-free fellow eyes with a foveal cyst on OCT represent an elevated risk (55%) for macular hole development. Vitreofoveal separation is probably a good prognostic sign.status: publishe

18 Years’ experience with high dose rate strontium-90 brachytherapy of small to medium sized posterior uveal melanoma

Aim: To analyse local tumour control, radiation related complications, visual acuity, enucleation rate, and survival after brachytherapy of small to medium sized choroidal melanoma (CM) with a high dose rate (HDR) strontium-90 (Sr-90) applicator. Methods: From 1983 until 2000, 98 eyes with CM were treated with Sr-90 brachytherapy. The main outcome measures were actuarial rates of the patients’ survival, ocular conservation rate, tumour regression, complication rates, and preservation of visual acuity. End point rates were estimated using Kaplan-Meier analysis. Results: The median follow up time was 6.7 years (0.5–18.8 years). Actuarial melanoma free patient survival rate was 85% (SE 4.8%) after 18 years. Actuarial rate of ocular conservation and complete tumour regression was 90% (SE 3.8%) after 15 years. In 93% local tumour control was achieved, 88% showed a stable scar. Recurrence of the tumour on the border caused enucleation of six eyes (7%). In three cases (4%) retinal detachment was the end point. No cases of optic atrophy or of sight impairing retinopathy outside the treated area were found. Actuarial rate of preservation of visual acuity of 1/10 was 65% at 5 years and 45% at 15 years of follow up (SE 5.9% and 8.8%). Conclusions: Sr-90 brachytherapy is as effective as iodine or ruthenium brachytherapy for small to medium sized CM but causes fewer complications. The preservation of vision is better than with all other described radioisotopes. HDR Sr-90 brachytherapy can therefore safely be recommended for small to medium sized CM