5,578 research outputs found
Strongly regular edge-transitive graphs
In this paper, we examine the structure of vertex- and edge-transitive
strongly regular graphs, using normal quotient reduction. We show that the
irreducible graphs in this family have quasiprimitive automorphism groups, and
prove (using the Classification of Finite Simple Groups) that no graph in this
family has a holomorphic simple automorphism group. We also find some
constraints on the parameters of the graphs in this family that reduce to
complete graphs.Comment: 23 page
Bounding the size of a vertex-stabiliser in a finite vertex-transitive graph
In this paper we discuss a method for bounding the size of the stabiliser of
a vertex in a -vertex-transitive graph . In the main result the
group is quasiprimitive or biquasiprimitive on the vertices of ,
and we obtain a genuine reduction to the case where is a nonabelian simple
group.
Using normal quotient techniques developed by the first author, the main
theorem applies to general -vertex-transitive graphs which are -locally
primitive (respectively, -locally quasiprimitive), that is, the stabiliser
of a vertex acts primitively (respectively
quasiprimitively) on the set of vertices adjacent to . We discuss how
our results may be used to investigate conjectures by Richard Weiss (in 1978)
and the first author (in 1998) that the order of is bounded above by
some function depending only on the valency of , when is
-locally primitive or -locally quasiprimitive, respectively
Twisted Permutation Codes
We introduce twisted permutation codes, which are frequency permutation
arrays analogous to repetition permutation codes, namely, codes obtained from
the repetition construction applied to a permutation code. In particular, we
show that a lower bound for the minimum distance of a twisted permutation code
is the minimum distance of a repetition permutation code. We give examples
where this bound is tight, but more importantly, we give examples of twisted
permutation codes with minimum distance strictly greater than this lower bound.Comment: 20 page
Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals
To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values. Insulin secretion was assessed using indexes derived from oral glucose tolerance test (OGTT). After adjusting for age, gender, and BMI, subjects in the highest (tertile 3) kisspeptin group exhibited significantly lower values of insulinogenic index, corrected insulin response (CIR30), and Stumvoll indexes for first-phase and second-phase insulin release as compared with low (tertile 1) or intermediate (tertile 2) kisspeptin groups. Univariate correlations between kisspeptin concentration and metabolic variables showed that kisspeptin concentration was significantly and positively correlated with age, blood pressure, and 2-h post-load glucose, and inversely correlated with BMI, and waist circumference. There was an inverse relationship between kisspeptin levels and OGTT-derived indexes of glucose-stimulated insulin secretion. A multivariable regression analysis in a model including all the variables significantly correlated with kisspeptin concentration showed thar age (β = -0.338, P<0.0001), BMI (β = 0.272, P<0.0001), 2-h post-load glucose (β = -0.229, P<0.0001), and kisspeptin (β = -0.105, P = 0.03) remained associated with insulinogenic index. These factors explained 34.6% of the variance of the insulinogenic index. In conclusion, kisspeptin concentrations are associated with insulin secretion independently of important determinants of glucose homeostasis such as gender, age, adiposity, 2-h post-load glucose, and insulin sensitivity
3D climate modeling of close-in land planets: Circulation patterns, climate moist bistability and habitability
The inner edge of the classical habitable zone is often defined by the
critical flux needed to trigger the runaway greenhouse instability. This 1D
notion of a critical flux, however, may not be so relevant for inhomogeneously
irradiated planets, or when the water content is limited (land planets).
Here, based on results from our 3D global climate model, we find that the
circulation pattern can shift from super-rotation to stellar/anti stellar
circulation when the equatorial Rossby deformation radius significantly exceeds
the planetary radius. Using analytical and numerical arguments, we also
demonstrate the presence of systematic biases between mean surface temperatures
or temperature profiles predicted from either 1D or 3D simulations.
Including a complete modeling of the water cycle, we further demonstrate that
for land planets closer than the inner edge of the classical habitable zone,
two stable climate regimes can exist. One is the classical runaway state, and
the other is a collapsed state where water is captured in permanent cold traps.
We identify this "moist" bistability as the result of a competition between the
greenhouse effect of water vapor and its condensation. We also present
synthetic spectra showing the observable signature of these two states.
Taking the example of two prototype planets in this regime, namely Gl581c and
HD85512b, we argue that they could accumulate a significant amount of water ice
at their surface. If such a thick ice cap is present, gravity driven ice flows
and geothermal flux should come into play to produce long-lived liquid water at
the edge and/or bottom of the ice cap. Consequently, the habitability of
planets at smaller orbital distance than the inner edge of the classical
habitable zone cannot be ruled out. Transiting planets in this regime represent
promising targets for upcoming observatories like EChO and JWST.Comment: Accepted for publication in Astronomy and Astrophysics, complete
abstract in the pdf, 18 pages, 18 figure
Insulin-like growth factor-1 is a negative modulator of glucagon secretion
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose. Insulin-like growth factor-I (IGF-1) has elevated homology with insulin, and regulates pancreatic β-cells insulin secretion. Insulin and IGF-1 receptors share considerable structure homology and function. We hypothesized the existence of a mechanism linking the inhibition of α-cells glucagon secretion to IGF-1. Herein, we evaluated the association between plasma IGF-1 and glucagon levels in 116 nondiabetic adults. After adjusting for age gender and BMI, fasting glucagon levels were positively correlated with 2-h post-load glycaemia, HOMA index and fasting insulin, and were negatively correlated with IGF-1 levels. In a multivariable regression, the variables independently associated to fasting glucagon were circulating IGF-1 levels, HOMA index and BMI, explaining 20.7% variation. To unravel the molecular mechanisms beneath IGF-1 and glucagon association, we investigated whether IGF-1 directly modulates glucagon expression and secretion in an in vitro model of α-cells. Our data showed that IGF-1 inhibits the ability of low glucose concentration to stimulate glucagon expression and secretion via activation of the phosphatidylinositol-3-kinase/Akt/FoxO1 pathway. Collectively, our results suggest a new regulatory role of IGF-1 on α-cells biological function
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Martian meso/micro-scale winds and surface energy budget
Regional, diurnal and seasonal variations of surface
temperature are particularly large on Mars. This is mostly due to the Martian surface remaining close to radiative equilibrium. Contrary to most terrestrial locations, contributions of sensible heat flux (i.e. conduction/convection exchanges between atmosphere and surface) to the surface energy budget [hereinafter SEB] are negligible on Mars owing to lowatmospheric density and heat capacity (e.g. Figure 2 in Savijärvi and Kauhanen, 2008). This radiative control of surface temperature is a key characteristic of the Martian environment and has crucial consequences on the the Martian geology, meteorology, exobiology, etc.
In order to identify the impact of this Martian peculiarity to near-surface regional-to-local atmospheric circulations,
we employ our recently-built Martian limited-area meteorological model (Spiga and Forget, 2009). We use horizontal resolutions adapted to the dynamical phenomena we aim to resolve: from several tens of kilometers to compute regional winds (mesoscale simulations) to several tens of meters to compute atmospheric boundary-layer winds (microscale or turbulent-resolving simulations, also called Large-Eddy Simulations, LES)
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