621 research outputs found
Crop Insurance Purchase Decisions: A Study of Northern Illinois Farmers
When selecting crop insurance coverage, farmers must consider multiple factors. The importance associated with factors that are considered when making crop insurance decisions varies among individual farmers. As available crop insurance options increase, selecting the appropriate coverage becomes a more complicated process. The prevalence of crop insurance participation and the existence of multiple selection criteria also makes understanding participant decisions more difficult. This paper provides findings of a mail survey conducted among farmers in northern Illinois. Mainly, this paper examines factors influencing farmers’ crop insurance purchase decisions, types of coverage purchased, and farmers’ risk attitudes.Crop Production/Industries,
Induction of carcinoembryonic antigen expression in a three-dimensional culture system
MIP-101 is a poorly differentiated human colon carcinoma cell line established from ascites that produces minimal amounts of carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, and nonspecific cross-reacting antigen (NCA), a related protein that has 50 and 90 kDa isoforms, in vitro in monolayer culture. MIP-101 produces CEA when implanted into the peritoneum of nude mice but not when implanted into subcutaneous tissue. We tested whether MIP-101 cells may be induced to express CEA when cultured on microcarrier beads in three-dimensional cultures, either in static cultures as non-adherent aggregates or under dynamic conditions in a NASA-designed low shear stress bioreactor. MIP- 101 cells proliferated well under all three conditions and increased CEA and NCA production 3 - 4 fold when grown in three-dimensional cultures compared to MIP-101 cells growing logarithmically in monolayers. These results suggest that three-dimensional growth in vitro simulates tumor function in vivo and that three-dimensional growth by itself may enhance production of molecules that are associated with the metastatic process
Dimension reduction for systems with slow relaxation
We develop reduced, stochastic models for high dimensional, dissipative
dynamical systems that relax very slowly to equilibrium and can encode long
term memory. We present a variety of empirical and first principles approaches
for model reduction, and build a mathematical framework for analyzing the
reduced models. We introduce the notions of universal and asymptotic filters to
characterize `optimal' model reductions for sloppy linear models. We illustrate
our methods by applying them to the practically important problem of modeling
evaporation in oil spills.Comment: 48 Pages, 13 figures. Paper dedicated to the memory of Leo Kadanof
A relocatable ocean model in support of environmental emergencies
During the Costa Concordia emergency case, regional, subregional, and relocatable ocean models have been used together with the oil spill model, MEDSLIK-II, to provide ocean currents forecasts, possible oil spill scenarios, and drifters trajectories simulations. The models results together with the evaluation of their performances are presented in this paper. In particular, we focused this work on the implementation of the Interactive Relocatable Nested Ocean Model (IRENOM), based on the Harvard Ocean Prediction System (HOPS), for the Costa Concordia emergency and on its validation using drifters released in the area of the accident. It is shown that thanks to the capability of improving easily and quickly its configuration, the IRENOM results are of greater accuracy than the results achieved using regional or subregional model products. The model topography, and to the initialization procedures, and the horizontal resolution are the key model settings to be configured. Furthermore, the IRENOM currents and the MEDSLIK-II simulated trajectories showed to be sensitive to the spatial resolution of the meteorological fields used, providing higher prediction skills with higher resolution wind forcing.MEDESS4MS Project; TESSA Project; MyOcean2 Projectinfo:eu-repo/semantics/publishedVersio
Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys
ホンヤク シン ジツザイロン テツガク ニ オケル キョウドウ ケンキュウ ジョブン
その他、フォーラム報告等(翻訳原稿)原著:Edwin Bissell Holt, Walter Taylor Marvin, William Pepperell Montague, Ralph Barton Perry, Walter Boughton Pitkin, Edward Gleason Spaulding, (1912),The New Realism : Cöperative Studies in Philosophy, New York The Macmillan Company.翻訳:豊泉, 俊大 / 磯島, 浩
HAE therapies: past present and future
Advances in understanding the pathophysiology and mechanism of swelling in hereditary angioedema (HAE) has resulted in the development of multiple new drugs for the acute and prophylactic treatment of patients with HAE. This review will recap the past treatment options, review the new current treatment options, and discuss potential future treatment options for patients with HAE
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Article discussing research on L- and M-shell x-ray production cross sections of Nd, Gd, Ho, Yb, Au, and Pb by 25-MeV carbon and 32-MeV oxygen ions
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