Assessment of psycho-emotional state of student with Mitral regurgitation and possible ways of its pharmacological correction

The article presents the results of psycho-emotional state assessment a person with Mitral regurgitation when he lies using the device for the physiological parameter record, and the possible ways of its pharmacological correction are offere

Analysis of Involvement of Cytokine Genetic Polymorphisms in Development of Genital Endometriosis

The article outlines the role of cytokines in development of genital endometriosis. There were detected associations between genetic polymorphisms and their combinations and development of genital endometriosis among women in the Central region of Russi

Candidate genes and clinical-laboratory parameters in pregnant women with preeclampsia

They studied the associations of genetic polymorphisms with clinico-laboratory indicators among pregnant women with preeclampsia depending on hereditary complicatio

Polymorphisms of genes and the risk of preeclampsia

They studied the relations of genetic polymorphisms with the risk of preeclampsia occurrence depending on hereditary complicatio

Shock Breakout in Type II Plateau Supernovae: Prospects for High Redshift Supernova Surveys

Shock breakout is the brightest radiative phenomenon in a supernova (SN) but is difficult to be observed owing to the short duration and X-ray/ultraviolet (UV)-peaked spectra. After the first observation from the rising phase reported in 2008, its observability at high redshift is attracting enormous attention. We perform multigroup radiation hydrodynamics calculations of explosions for evolutionary presupernova models with various main-sequence masses $M_{\rm MS}$, metallicities $Z$, and explosion energies $E$. We present multicolor light curves of shock breakout in Type II plateau SNe, being the most frequent core-collapse SNe, and predict apparent multicolor light curves of shock breakout at various redshifts $z$. We derive the observable SN rate and reachable redshift as functions of filter $x$ and limiting magnitude $m_{x,{\rm lim}}$ by taking into account an initial mass function, cosmic star formation history, intergalactic absorption, and host galaxy extinction. We propose a realistic survey strategy optimized for shock breakout. For example, the $g'$-band observable SN rate for $m_{g',{\rm lim}}=27.5$ mag is 3.3 SNe degree$^{-2}$ day$^{-1}$ and a half of them locates at $z\geq1.2$. It is clear that the shock breakout is a beneficial clue to probe high-$z$ core-collapse SNe. We also establish ways to identify shock breakout and constrain SN properties from the observations of shock breakout, brightness, time scale, and color. We emphasize that the multicolor observations in blue optical bands with $\sim$ hour intervals, preferably over $\geq2$ continuous nights, are essential to efficiently detect, identify, and interpret shock breakout.Comment: 26 pages, 23 figures. Accepted for publication in the Astrophysical Journal Supplement Serie

Insilico test of functional role of rs8068318 polymorphism of arterial hypertension-associated TBX2 candidate gene

In the course of this study, the functional role of rs8068318 polymorphism of the TBX2 candidate gene associated with the development of arterial hypertension was studied. The selection of the polymorphic locus was based on the data of the catalog of genome-wide association study (GWAS) of the National Human Genome Research Institute. The functional role was evaluated using online software: HaploReg (v4.1), GTExportal, and PolyPhen-

Genetic factors of decreased kidney function in patients with chronic glomerulonephritis

The article presents the results of studying the interaction of polymorphic variants of vascular homeostasis genes (I/D ACE, 4а/4b eNOS, S311C PON2, (-6) A/G AGT, (-1166) A/С AGTR1, G/A GNB3 (rs.2301339), G460W ADD1, (+46) G/A ADRB2, K198N EDN1, (+6986) G/A CYP3A5) with the state of renal function at the onset of chronic glomerulonephriti

CURRENT ISSUES OF APPLICATION OF FOREIGN EXPERIENCE OF PREDICTING THE ECONOMIC NEEDS IN QUALIFIED PERSONS IN PRACTICE OF GOVERNMENT MANAGEMENT IN RUSSIAN FEDERATION

It is shown that in highly developed countries a balance models and general computable equilibrium models are used to predict the dynamics of labor and employment markets. It was noted that a holistic approach to forecasting the needs of the national economies in qualified personnel was developed abroad, based on the optimal combination of quantitative and qualitative methods. The necessity of revealing and analyzing the factors determining the current and prospective demand and supply of labor in the digital economy is substantiated. The expediency of creating an early warning system in the Russian Federation that allows timely detection of trends in the dynamics of demand and supply of skilled labor in order to develop strategic forecasts of the labor market and the formation of an effective state employment policy is argued

The pedagogical design technology in creation massive open online courses

The article describes the main features of application the pedagogical design technology in creation the education space of massive open online coursesВ статье раскрываются особенности применения технологии педагогического дизайна при организации образовательного пространства массовых открытых онлайн-курсо