27 research outputs found

    Passive Processing of Active Nodal Seismic Data: Estimation of Vp∕Vs Ratios to Characterize Structure and Hydrology of an Alpine Valley Infill

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    The advent of cable-free nodal arrays for conventional seismic reflection and refraction experiments is changing the acquisition style for active-source surveys. Instead of triggering short recording windows for each shot, the nodes are continuously recording over the entire acquisition period from the first to the last shot. The main benefit is a significant increase in geometrical and logistical flexibility. As a by-product, a significant amount of continuous data might also be collected. These data can be analyzed with passive seismic methods and therefore offer the possibility to complement subsurface characterization at marginal additional cost. We present data and results from a 2.4 km long active-source profile, which have recently been acquired in western Colorado (US) to characterize the structure and sedimentary infill of an over-deepened alpine valley. We show how the “leftover” passive data from the active-source acquisition can be processed towards a shear wave velocity model with seismic interferometry. The shear wave velocity model supports the structural interpretation of the active P-wave data, and the P-to-S-wave velocity ratio provides new insights into the nature and hydrological properties of the sedimentary infill. We discuss the benefits and limitations of our workflow and conclude with recommendations for the acquisition and processing of similar datasets.This research has been partially supported by the National Science Foundation (NSF-EAR-1338331). Open Access fees paid for in whole or in part by the University of Oklahoma Libraries.Ye

    An Exhumed Late Paleozoic Canyon in the Rocky Mountains

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    Landscapes are thought to be youthful, particularly those of active orogenic belts. Unaweep Canyon in the Colorado Rocky Mountains, a large gorge drained by two opposite‐flowing creeks, is an exception. Its origin has long been enigmatic, but new data indicate that it is an exhumed late Paleozoic landform. Its survival within a region of profound late Paleozoic orogenesis demands a reassessment of tectonic models for the Ancestral Rocky Mountains, and its form and genesis have significant implications for understanding late Paleozoic equatorial climate. This discovery highlights the utility of paleogeomorphology as a tectonic and climatic indicator

    Coarse-Grained, Deep-Water Sedimentation Along a Border Fault Margin of Lake Malawi, Africa: Seismic Stratigraphic Analysis

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    Lake Malawi, Africa, serves as an important modern analog for understanding depositional processes in an active rift setting. This paper explores the depositional processes and stacking patterns of coarse-grained facies across a large fan delta and associated sub-lacustrine fan system offshore of the South Rukuru River using single-channel seismic data coupled with deep-water vibracores and gravity cores. A companion paper (Wells et al. 1999) discusses the details of the depositional processes of the system inferred from core data. Using 2900 km of single-channel seismic data, eight genetic facies were defined based on seismic reflection character, external geometry, accompanying core data, and location within the modern geomorphic system. Five sand-dominated facies include; (1) mouth-of-canyon-fan facies; (2) progradational-fan-delta facies; (3) channel-fill facies; (4) canyon-fill facies; and (5) basin-plain-fill facies. These facies occur as surficial deposits in water depths of more than 600 m, suggesting that coarse-grained sedimentation characterizes certain localities, in even the deepest parts of Lake Malawi. Climatically driven lake-level changes influenced the internal character of these facies, their thickness, and to some extent their location within the South Rukuru study area. However, climate was generally subordinate to tectonism in controlling the temporal and spatial distribution of the facies. Tectonic controls can be categorized as; (1) orientation of the first-order border fault and intrabasinal faults; (2) syndepositional footwall uplift and rotation; and (3) temporal changes in the rate and location of maximum subsidence. These controls affect the location and stacking of the mouth-of-canyon fans, and the presence and orientation of sub-lacustrine canyons and the zone of maximum sediment accumulation, and depositional gradients

    Climate, Vegetation, and Weathering across Space and Time in Lake Tanganyika (Tropical Eastern Africa)

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    Climate and vegetation influence weathering rates and processes; however, evaluating the effects of each and feedbacks between systems, has yet to be accomplished for many types of landscapes. A detailed understanding of how these processes interact to shape landscapes is particularly crucial for reconciling future scenarios of changing climate, where profound alterations to both the biosphere and geosphere are anticipated. In the tropics, ecosystem services, such as soil and water quality, are linked to both vegetation and weathering processes that form a strong control on natural resources that are the foundation of many communities’ daily subsistence. This understanding is further complicated by intensifying land-use within tropical watersheds, which decouples vegetation change from climate; it is yet unclear what the direct effects of vegetation change may be on erosion and weathering when operating independent of climate. Long term observational records tracking changes to the critical zone do not exist in tropical Africa, however, sedimentary paleo-records from lakes are often of sufficient length and resolution to record the impact of bioclimatic variability on surface processes. Here, we use a novel approach combining long (60ka) and intermediate-length (400yrs) lake sediment records along with historical repeat photography from Lake Tanganyika (Tanzania) to document changes and relationships among climate, vegetation, and weathering at multiple scales. These records illustrate that glacial-interglacial climate change did not significantly alter weathering intensity. Instead, we observe chemical and physical weathering responses only when the vegetation becomes more open beginning at the transition to the Holocene. Also, the largest change in chemical weathering intensity occurs only within the last ∼3ka. This is consistent with a major reorganization of vegetation and is directly attributable to Iron Age human activity, rather than climate. Furthermore, anthropogenic landscape alteration as early as ∼2.5ka, in addition to well-documented comparisons of historical land-use, suggest widespread responses of both chemical weathering intensity and enhanced soil erosion to human activity. This shows that changes in vegetation structure induced by anthropogenic activity, decoupled from climate change, generate a disproportionately large weathering response

    Report on ICDP Deep Dust workshops: probing continental climate of the late Paleozoic icehouse–greenhouse transition and beyond

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    Chamberlin and Salisbury's assessment of the Permian a century ago captured the essence of the period: it is an interval of extremes yet one sufficiently recent to have affected a biosphere with near-modern complexity. The events of the Permian - the orogenic episodes, massive biospheric turnovers, both icehouse and greenhouse antitheses, and Mars-analog lithofacies - boggle the imagination and present us with great opportunities to explore Earth system behavior. The ICDP-funded workshops dubbed "Deep Dust," held in Oklahoma (USA) in March 2019 (67 participants from nine countries) and Paris (France) in January 2020 (33 participants from eight countries), focused on clarifying the scientific drivers and key sites for coring continuous sections of Permian continental (loess, lacustrine, and associated) strata that preserve high-resolution records. Combined, the two workshops hosted a total of 91 participants representing 14 countries, with broad expertise. Discussions at Deep Dust 1.0 (USA) focused on the primary research questions of paleoclimate, paleoenvironments, and paleoecology of icehouse collapse and the run-up to the Great Dying and both the modern and Permian deep microbial biosphere. Auxiliary science topics included tectonics, induced seismicity, geothermal energy, and planetary science. Deep Dust 1.0 also addressed site selection as well as scientific approaches, logistical challenges, and broader impacts and included a mid-workshop field trip to view the Permian of Oklahoma. Deep Dust 2.0 focused specifically on honing the European target. The Anadarko Basin (Oklahoma) and Paris Basin (France) represent the most promising initial targets to capture complete or near-complete stratigraphic coverage through continental successions that serve as reference points for western and eastern equatorial Pangaea.This research has been supported by the ICDP (DeepDust2019 grant).Ye

    Heterologous Amyloid Seeding: Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease

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    Neurodegenerative diseases associated with abnormal protein folding and ordered aggregation require an initial trigger which may be infectious, inherited, post-inflammatory or idiopathic. Proteolytic cleavage to generate vulnerable precursors, such as amyloid-β peptide (Aβ) production via β and γ secretases in Alzheimer's Disease (AD), is one such trigger, but the proteolytic removal of these fragments is also aetiologically important. The levels of Aβ in the central nervous system are regulated by several catabolic proteases, including insulysin (IDE) and neprilysin (NEP). The known association of human acetylcholinesterase (hAChE) with pathological aggregates in AD together with its ability to increase Aβ fibrilization prompted us to search for proteolytic triggers that could enhance this process. The hAChE C-terminal domain (T40, AChE575-614) is an exposed amphiphilic α-helix involved in enzyme oligomerisation, but it also contains a conformational switch region (CSR) with high propensity for conversion to non-native (hidden) β-strand, a property associated with amyloidogenicity. A synthetic peptide (AChE586-599) encompassing the CSR region shares homology with Aβ and forms β-sheet amyloid fibrils. We investigated the influence of IDE and NEP proteolysis on the formation and degradation of relevant hAChE β-sheet species. By combining reverse-phase HPLC and mass spectrometry, we established that the enzyme digestion profiles on T40 versus AChE586-599, or versus Aβ, differed. Moreover, IDE digestion of T40 triggered the conformational switch from α- to β-structures, resulting in surfactant CSR species that self-assembled into amyloid fibril precursors (oligomers). Crucially, these CSR species significantly increased Aβ fibril formation both by seeding the energetically unfavorable formation of amyloid nuclei and by enhancing the rate of amyloid elongation. Hence, these results may offer an explanation for observations that implicate hAChE in the extent of Aβ deposition in the brain. Furthermore, this process of heterologous amyloid seeding by a proteolytic fragment from another protein may represent a previously underestimated pathological trigger, implying that the abundance of the major amyloidogenic species (Aβ in AD, for example) may not be the only important factor in neurodegeneration

    Structural Elements Regulating Amyloidogenesis: A Cholinesterase Model System

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    Polymerization into amyloid fibrils is a crucial step in the pathogenesis of neurodegenerative syndromes. Amyloid assembly is governed by properties of the sequence backbone and specific side-chain interactions, since fibrils from unrelated sequences possess similar structures and morphologies. Therefore, characterization of the structural determinants driving amyloid aggregation is of fundamental importance. We investigated the forces involved in the amyloid assembly of a model peptide derived from the oligomerization domain of acetylcholinesterase (AChE), AChE586-599, through the effect of single point mutations on β-sheet propensity, conformation, fibrilization, surfactant activity, oligomerization and fibril morphology. AChE586-599 was chosen due to its fibrilization tractability and AChE involvement in Alzheimer's disease. The results revealed how specific regions and residues can control AChE586-599 assembly. Hydrophobic and/or aromatic residues were crucial for maintaining a high β-strand propensity, for the conformational transition to β-sheet, and for the first stage of aggregation. We also demonstrated that positively charged side-chains might be involved in electrostatic interactions, which could control the transition to β-sheet, the oligomerization and assembly stability. Further interactions were also found to participate in the assembly. We showed that some residues were important for AChE586-599 surfactant activity and that amyloid assembly might preferentially occur at an air-water interface. Consistently with the experimental observations and assembly models for other amyloid systems, we propose a model for AChE586-599 assembly in which a steric-zipper formed through specific interactions (hydrophobic, electrostatic, cation-π, SH-aromatic, metal chelation and polar-polar) would maintain the β-sheets together. We also propose that the stacking between the strands in the β-sheets along the fiber axis could be stabilized through π-π interactions and metal chelation. The dissection of the specific molecular recognition driving AChE586-599 amyloid assembly has provided further knowledge on such poorly understood and complicated process, which could be applied to protein folding and the targeting of amyloid diseases

    ICDP workshop on the Lake Tanganyika Scientific Drilling Project: a late Miocene–present record of climate, rifting, and ecosystem evolution from the world's oldest tropical lake

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    The Neogene and Quaternary are characterized by enormous changes in global climate and environments, including global cooling and the establishment of northern high-latitude glaciers. These changes reshaped global ecosystems, including the emergence of tropical dry forests and savannahs that are found in Africa today, which in turn may have influenced the evolution of humans and their ancestors. However, despite decades of research we lack long, continuous, well-resolved records of tropical climate, ecosystem changes, and surface processes necessary to understand their interactions and influences on evolutionary processes. Lake Tanganyika, Africa, contains the most continuous, long continental climate record from the mid-Miocene (∼10 Ma) to the present anywhere in the tropics and has long been recognized as a top-priority site for scientific drilling. The lake is surrounded by the Miombo woodlands, part of the largest dry tropical biome on Earth. Lake Tanganyika also harbors incredibly diverse endemic biota and an entirely unexplored deep microbial biosphere, and it provides textbook examples of rift segmentation, fault behavior, and associated surface processes. To evaluate the interdisciplinary scientific opportunities that an ICDP drilling program at Lake Tanganyika could offer, more than 70 scientists representing 12 countries and a variety of scientific disciplines met in Dar es Salaam, Tanzania, in June 2019. The team developed key research objectives in basin evolution, source-to-sink sedimentology, organismal evolution, geomicrobiology, paleoclimatology, paleolimnology, terrestrial paleoecology, paleoanthropology, and geochronology to be addressed through scientific drilling on Lake Tanganyika. They also identified drilling targets and strategies, logistical challenges, and education and capacity building programs to be carried out through the project. Participants concluded that a drilling program at Lake Tanganyika would produce the first continuous Miocene–present record from the tropics, transforming our understanding of global environmental change, the environmental context of human origins in Africa, and providing a detailed window into the dynamics, tempo and mode of biological diversification and adaptive radiations.© Author(s) 2020. This open access article is distributed under the Creative Commons Attribution 4.0 License
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