867 research outputs found
Large enhancement of the photovoltaic effect in ferroelectric complex oxides through bandgap reduction
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Tuning the bandgap in ferroelectric complex oxides is a possible route for improving the photovoltaic activity of materials. Here, we report the realization of this effect in epitaxial thin films of the ferroelectric complex oxide Bi3.25La0.75Ti3O12 (BLT) suitably doped by Fe and Co. Our study shows that Co (BLCT) doping and combined Fe, Co (BLFCT) doping lead to a reduction of the bandgap by more than 1 eV compared to undoped BLT, accompanied by a surprisingly more efficient visible light absorption. Both BLCT and BLFCT films can absorb visible light with a wavelength of up to 500 nm while still exhibiting ferroelectricity, whereas undoped BLT only absorbs UV light with a wavelength of less than 350 nm. Correlated with its bandgap reduction, the BLFCT film shows a photocurrent density enhanced by 25 times compared to that of BLT films. Density functional theory calculations indicate that the bandgap contraction is caused by the formation of new energy states below the conduction bands due to intermixed transition metal dopants (Fe, Co) in BLT. This mechanism of tuning the bandgap by simple doping can be applied to other wide-bandgap complex oxides, thereby enabling their use in solar energy conversion or optoelectronic applications
f(R) theories
- Author
- A Balcerzak
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- Ă Cruz-Dombriz de la
- ĂĂ Flanagan
- ĂĂ Flanagan
- ĂĂ Flanagan
- Publication venue
- 'Living Reviews'
- Publication date
- 01/06/2010
- Field of study
Over the past decade, f(R) theories have been extensively studied as one of
the simplest modifications to General Relativity. In this article we review
various applications of f(R) theories to cosmology and gravity - such as
inflation, dark energy, local gravity constraints, cosmological perturbations,
and spherically symmetric solutions in weak and strong gravitational
backgrounds. We present a number of ways to distinguish those theories from
General Relativity observationally and experimentally. We also discuss the
extension to other modified gravity theories such as Brans-Dicke theory and
Gauss-Bonnet gravity, and address models that can satisfy both cosmological and
local gravity constraints.Comment: 156 pages, 14 figures, Invited review article in Living Reviews in
Relativity, Published version, Comments are welcom
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at â s = 8 TeV with the ATLAS detector
- Author
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- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
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- Acharya BS
- Achkar B
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- Adamczyk L
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- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
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- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
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- Colijn AP
- Collot J
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- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fbâ1 of â s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at sâ=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
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- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fbâ1 of protonâproton collision data at âs = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via tËâtÏË01 or tËâ bÏ˱1 âbW(â)ÏË01 , where ÏË01 (Ï˱1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of tË â tÏË01 . For a branching fraction of 100%, top squark masses in the range 270â645 GeV are excluded for ÏË01 masses below 30 GeV. For a branching fraction of 50% to either tË â tÏË01 or tË â bÏ˱1 , and assuming the Ï˱1 mass to be twice the ÏË01 mass, top squark masses in the range 250â550 GeV are excluded for ÏË01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at âs=8TeV
- Author
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- Yao W-M
- Yasu Y
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- Yildirim E
- Yildiz HD
- Yilmaz M
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- Yoshihara K
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- Youssef S
- Yu DR
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- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
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- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
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- Zhu H
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- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fbâ1of data collected in protonâproton collisions at âs=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc
- Author
- A Boom
- A Deshpande
- A Rozkalne
- A Sandberg
- A Sydow
- AI Bush
- AI Bush
- AS Yoo
- AY Hsia
- C Corona
- C Sindreu
- C Supnet
- CW Christine
- D Scheuner
- D Tampellini
- D Tampellini
- DM Walsh
- E Abramov
- E Stieren
- E Zampese
- EM Snyder
- F Kamenetz
- F Zheng
- FA Rassendren
- FG De Felice
- FM LaFerla
- G Lyubartseva
- G Rojas
- GE Stutzmann
- GE Stutzmann
- GL Collingridge
- GM Bishop
- GM Shankar
- H Hsieh
- H Martinez-Coria
- H Tu
- H Zempel
- HW Querfurth
- HY Wu
- I Veinbergs
- J Dong
- J Gotz
- J Gotz
- J Herms
- J Qian
- JC Diaz
- JD Buxbaum
- JJ Hwang
- JL Smith
- JR Cirrito
- JR Lopez
- JY Lee
- JY Lee
- K Garai
- K Hirzel
- K Ueda
- KH Cheung
- KN Green
- KN Green
- KV Kuchibhotla
- L Besser
- L Lannfelt
- L Mucke
- LM Billings
- LM Ittner
- M Hershfinkel
- M Ho
- M Jin
- MA Leissring
- MA Lovell
- MA Lovell
- MA Lovell
- MA Petryniak
- ME Harris
- ML Mayer
- MP Cuajungco
- MP Mattson
- MS Song
- N Arispe
- N Pierrot
- NG Faux
- NW Hu
- OA Shipton
- P Legendre
- PA Adlard
- PA Adlard
- PA Adlard
- RA Cherny
- RA Velazquez
- S Bakchine
- S Chakroborty
- S Garg
- S Melov
- SE Hoey
- SF Lichtenthaler
- SL Sensi
- SL Sensi
- SL Sensi
- SL Sensi
- ST DeKosky
- SW Pimplikar
- SW Suh
- SY Park
- U Dreses-Werringloer
- UV Nagerl
- V Nimmrich
- V Rybalchenko
- W Wei
- WQ Zhao
- X Huang
- Y Miller
- Y Miller
- Y Niu
- YZ Huang
- Z Molnar
- Z Wang
- ZS Khachaturian
- ZY Mo
- Publication venue
- Nature Publishing Group
- Publication date
- 01/06/2011
- Field of study
The molecular determinants of Alzheimer's (AD) disease are still not completely known; however, in the past two decades, a large body of evidence has indicated that an important contributing factor for the disease is the development of an unbalanced homeostasis of two signaling cations: calcium (Ca2+) and zinc (Zn2+). Both ions serve a critical role in the physiological functioning of the central nervous system, but their brain deregulation promotes amyloid-ÎČ dysmetabolism as well as tau phosphorylation. AD is also characterized by an altered glutamatergic activation, and glutamate can promote both Ca2+ and Zn2+ dyshomeostasis. The two cations can operate synergistically to promote the generation of free radicals that further intracellular Ca2+ and Zn2+ rises and set the stage for a self-perpetuating harmful loop. These phenomena can be the initial steps in the pathogenic cascade leading to AD, therefore, therapeutic interventions aiming at preventing Ca2+ and Zn2+ dyshomeostasis may offer a great opportunity for disease-modifying strategies
Transcriptome Analysis of the Desert Locust Central Nervous System: Production and Annotation of a Schistocerca gregaria EST Database
- Author
- A Conesa
- A Donini
- A Ichiyama
- A Macins
- A Tam
- AB Hummon
- AG Maule
- AJ Riveros
- AP West Jr
- AP Woodhead
- AR Mercer
- Arnold De Loof
- B Boerjan
- B Ewing
- B Ewing
- B Fournier
- B Hoste
- B Li
- B Querat
- B Uvarov
- B Uvarov
- BF Hagele
- C Durst
- C Kupprion
- C Wegener
- C Wegener
- CD Minth
- CG Kumar
- CL Corless
- CW Luo
- D Boureme
- D Filmore
- D Veelaert
- D Xu
- DA Cullen
- DA Wassarman
- DJ Brierley
- DJ Van der Horst
- DR Nassel
- E Clynen
- E Clynen
- E Clynen
- E Clynen
- E Lehmberg
- E Quevillon
- E Vanhems
- EF Kirkness
- Elisabeth Marchal
- EM Dewey
- EW Raines
- F Hauser
- F Hauser
- FM Mendive
- G Baggerman
- G Boyan
- G Fraenkel
- G Gade
- G Gade
- G Gade
- GE Pratt
- Gert Simonet
- GJ Goldsworthy
- GR Huesmann
- GS Withers
- H Hietter
- H Kataoka
- H Kataoka
- H Luan
- H Sage
- H Sage
- H Sage
- H Song
- H Song
- H Song
- H Verlinden
- H Verlinden
- HA Dierick
- Heleen Verlinden
- HF Kwok
- HW Honegger
- I Boime
- I Claeys
- I Claeys
- I Claeys
- I Claeys
- I Kay
- I Mertens
- J Axelrod
- J Girardie
- J Girardie
- J Girardie
- J Huybrechts
- J Marshall
- J Marshall
- J Meredith
- J Stangier
- J Stangier
- J Vanden Broeck
- J Vanden Broeck
- J Vanden Broeck
- J Vanden Broeck
- J Vanden Broeck
- J Vandesompele
- JA Veenstra
- JE Casida
- JE Murphy-Ullrich
- JE Phillips
- JG Christenson
- Jialin Zheng
- Jozef Vanden Broeck
- JR Hwang
- Jurgen Huybrechts
- JV Stone
- JW Johnson
- K Berthier
- K Erreger
- K Fujimura-Kamada
- K Hatsuzawa
- KJ Siegert
- KS Lee
- KS Lee
- L Badisco
- L Badisco
- L Kang
- L Paemen
- L Roller
- L Schoofs
- L Schoofs
- L Schoofs
- L Schoofs
- L Schoofs
- L Wang
- LE Macdonald
- Liesbeth Badisco
- Liliane Schoofs
- LR Lester
- M Ashburner
- M Lagueux
- M Ma
- M Mayford
- M Spehr
- MA Mena
- MA Riehle
- MB Morris
- MB Van Hiel
- ME Chen
- MF Bonaldo
- MF Schulz-Aellen
- ML Anstey
- MM Rahman
- MM Rahman
- MM Rahman
- MO Huising
- MP Pener
- MP Pener
- MR Brown
- N Audsley
- N Audsley
- N Geva
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- N Macours
- N Macours
- N Macours
- N Yamanaka
- NG Seidah
- NG Seidah
- NG Seidah
- NJ Tublitz
- NJ Tublitz
- NJ Tublitz
- NJ Tublitz
- NS Lamango
- P Corvol
- P Hasselaar
- P Kloppenburg
- P Towner
- P Verleyen
- PJ Wilmore
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- PS Leung
- Q Wu
- R Day
- R Dukas
- R Isaac
- R Moreau
- R Predel
- RA Brekken
- RE Isaac
- RJ Weaver
- Roger Huybrechts
- RX Wu
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- S Benjannet
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- S Dimitrova
- S Gotz
- S Hunter
- S Rosenblatt
- S Sudo
- SE Funk
- SF Altschul
- SF Garczynski
- SF Garczynski
- SF Garczynski
- SJ Simpson
- SJ Simpson
- SM Rajpara
- SM Rogers
- SM Rogers
- SP Smeekens
- SR Ott
- SR Schmid
- SY Hsu
- T Janssen
- T Kidd
- T Knopfel
- T Nagatsu
- T Van Loy
- TH Barker
- V Gongidi
- VA Skeberdis
- W Gronenberg
- W Lovenberg
- WA Golembieski
- WG Bendena
- WJ Curry
- WJ Van de Ven
- WK So
- WW Ja
- WW Ja
- X Zhu
- Y Molina
- Y Molina
- ZY Ma
- Publication venue
- Public Library of Science
- Publication date
- 21/03/2011
- Field of study
) displays a fascinating type of phenotypic plasticity, designated as âphase polyphenismâ. Depending on environmental conditions, one genome can be translated into two highly divergent phenotypes, termed the solitarious and gregarious (swarming) phase. Although many of the underlying molecular events remain elusive, the central nervous system (CNS) is expected to play a crucial role in the phase transition process. Locusts have also proven to be interesting model organisms in a physiological and neurobiological research context. However, molecular studies in locusts are hampered by the fact that genome/transcriptome sequence information available for this branch of insects is still limited. EST information is highly complementary to the existing orthopteran transcriptomic data. Since many novel transcripts encode neuronal signaling and signal transduction components, this paper includes an overview of these sequences. Furthermore, several transcripts being differentially represented in solitarious and gregarious locusts were retrieved from this EST database. The findings highlight the involvement of the CNS in the phase transition process and indicate that this novel annotated database may also add to the emerging knowledge of concomitant neuronal signaling and neuroplasticity events. EST data constitute an important new source of information that will be instrumental in further unraveling the molecular principles of phase polyphenism, in further establishing locusts as valuable research model organisms and in molecular evolutionary and comparative entomology
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A DĂĄvalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
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- A Nijnik
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- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
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- A Pradhan
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- A Rattner
- A Ravati
- A Rehman
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- A Richmond
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- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
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- TY Tsai
- U Alon
- U Bartels
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- U Cha'on
- U Eckstein-Ludwig
- U Heinz
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- U Schönbeck
- UN Das
- V Adam-Vizi
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- Y Wang
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- Y Wu
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- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
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- YF Chu
- YH Lee
- YH Suh
- YH Wei
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- YM Kim
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- Z Zhang
- ZD Liu
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- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
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- Abdallah RI
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- Henschel B
- Heras G
- Hernandis V
- HernĂĄndez A
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez G
- HernĂĄndez-Tejedor A
- Herpain A
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- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
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- Heunks LM
- Hewitt H
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- Hillier SD
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- Himpe D
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- Hirata A
- Hirayama T
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- Hodgson LE
- Hodgson LE
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- Houzé S
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- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
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- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
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- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
- Hung WT
- Hung WT
- Hung WT
- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
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- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
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- Jian Z
- Jiao LR
- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
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- Kang PL
- Kang PL
- Kang PL
- Kang Y
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- Kappler F
- Kara A
- Karachi F
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- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
- Katabami K
- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
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- Kawano S
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- Kayaaslan B
- Kayambu G
- Kazutoshi F
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- Khaliq W
- Khine H
- Kim DJ
- Kim HJ
- Kim JM
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- Kim JW
- Kim KS
- Kim KS
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- Kim KS
- Kim MH
- Kim MH
- Kim W
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- Kirakli C
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- Kirwan CJ
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- Kleinpell R
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- Knafelj R
- Knight LD
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- Ko SB
- Kobayashi A
- Koco E
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- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
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- Kosuk ME
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- Kou PS
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- Kox M
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- Krenn CG
- Krishna B
- Kristof J
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- Kruger A
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- Kuebler WM
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- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
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- Kwon HM
- Kwon WY
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- Kyle UG
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- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
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- Lagos R
- Lahmer T
- Lai CC
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- Latini R
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- Latini R
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- Leitao AL
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- Lichtenstein D
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- Limuti R
- Lin KC
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- Lischinsky A
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- Lukaszewicz AC
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- Muhammad JB
- Mukherjee DN
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Ălvarez JT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
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- Adolph TE
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- Agrewala JN
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- Alaoui-Jamali MA
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- Alessandri C
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- Alizadeh J
- Almacellas E
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- Alonso A
- Alonso GD
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- Ammanathan V
- An Z
- Andersen SU
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- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
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