4 research outputs found
Development and In vitro Evaluation of Betahistine Adhesive-Type Transdermal Delivery System
Purpose: To develop a transdermal betahistine (BTH) delivery system using different pressure sensitive adhesives (PSAs) including acrylics, polyisobutylene and styrenic rubber solution.Methods: Formulations were prepared by solvent casting and adhesive transfer method. PSAs - acrylate vinylacetate (AVA), hydrophilic acrylate (HA), acrylic non-curing (ANC), polyisobutylene (PIB), and tackified styrenic rubber solution (TSR) - were evaluated for their suitability in terms of miscibility, maximum drug loading, effect on tack property and in vitro permeation through excised guinea pig skin. Furthermore, one of the PSAs was tested in relation to effect of penetration enhancers on tack property, in vitro permeation, in vivo patch adhesion performance and stability.Results: Only formulations prepared with AVA and HA were stable. Increased drug loading in these PSAs significantly reduced tack. In vitro permeation data across guinea pig skin demonstrated that BTH flux from from the formulation containing HA (F1) was significantly (p < 0.001) higher than that containing AVA (F2). Formulations containing 2 % enhancer showed good tack. Specifically, the formulation containing 2 % oleic acid as enhancer not only showed the highest permeation but also good tack property, non-irritancy for up to 36 h and stability under accelerated conditions.Conclusion: The formulation containing HA as the PSA and 2 % oleic acid as enhancer demonstrated a good potential for further development to an adhesive-type transdermal delivery system for BTH.Keywords: Meniere’s syndrome, Transdermal delivery, Betahistine, Pressure-sensitive adhesives, Penetration enhancersTropical Journal of Pharmaceutical Research December 2010; 9 (6): 516-52
Development and In vitro Evaluation of Betahistine Adhesive-Type Transdermal Delivery System
Purpose: To develop a transdermal betahistine (BTH) delivery system
using different pressure sensitive adhesives (PSAs) including acrylics,
polyisobutylene and styrenic rubber solution. Methods: Formulations
were prepared by solvent casting and adhesive transfer method. PSAs
acrylate vinylacetate (AVA), hydrophilic acrylate (HA), acrylic
non-curing (ANC), polyisobutylene (PIB), and tackified styrenic rubber
solution (TSR) -were evaluated for their suitability in terms of
miscibility, maximum drug loading, effect on tack property and in vitro
permeation through excised guinea pig skin. Furthermore, one of the
PSAs was tested in relation to effect of penetration enhancers on tack
property, in vitro permeation, in vivo patch adhesion performance and
stability. Results: Only formulations prepared with AVA and HA were
stable. Increased drug loading in these PSAs significantly reduced
tack. In vitro permeation data across guinea pig skin demonstrated that
BTH flux from from the formulation containing HA (F1) was significantly
(p < 0.001) higher than that containing AVA (F2). Formulations
containing 2 % enhancer showed good tack. Specifically, the formulation
containing 2 % oleic acid as enhancer not only showed the highest
permeation but also good tack property, non-irritancy for up to 36 h
and stability under accelerated conditions. Conclusion: The formulation
containing HA as the PSA and 2 % oleic acid as enhancer demonstrated a
good potential for further development to an adhesive-type transdermal
delivery system for BTH
Alkaliphiles : The Emerging Biological Tools Enhancing Concrete Durability
Concrete is one of the most commonly used building materials ever used. Despite it is a very important and common construction material, concrete is very sensitive to crack formation and requires repair. A variety of chemical-based techniques and materials have been developed to repair concrete cracks. Although the use of these chemical-based repair systems are the best commercially available choices, there have also been concerns related to their use. These repair agents suffer from inefficiency and unsustainability. Most of the products are expensive and susceptible to degradation, exhibit poor bonding to the cracked concrete surfaces, and are characterized by different physical properties such as thermal expansion coefficients which are different to that of concrete. Moreover, many of these repair agents contain chemicals that pose environmental and health hazards. Thus, there has been interest in developing concrete crack repair agents that are efficient, long lasting, safe, and benign to the environment and exhibit physical properties which resemble that of the concrete. The search initiated by these desires brought the use of biomineralization processes as tools in mending concrete cracks. Among biomineralization processes, microbially initiated calcite precipitation has emerged as an interesting alternative to the existing chemical-based concrete crack repairing system. Indeed, results of several studies on the use of microbial-based concrete repair agents revealed the remarkable potential of this approach in the fight against concrete deterioration. In addition to repairing existing concrete cracks, microorganisms have also been considered to make protective surface coating (biodeposition) on concrete structures and in making self-healing concrete. Even though a wide variety of microorganisms can precipitate calcite, the nature of concrete determines their applicability. One of the important factors that determine the applicability of microbes in concrete is pH. Concrete is highly alkaline in nature, and hence the microbes envisioned for this application are alkaliphilic or alkali-tolerant. This work reviews the available information on applications of microbes in concrete: repairing existing cracks, biodeposition, and self-healing. Moreover, an effort is made to discuss biomineralization processes that are relevant to extend the durability of concrete structures