Memoria histórica y sistematización de experiencias de la comunidad muisca de Sesquilé

Trabajo de InvestigaciónEl objetivo de la investigación fue recuperar la memoria histórica de la Comunidad Mhuysqa de Sesquilé y sistematización de experiencias de la misma, a través de técnicas participativas como diarios de campo, entrevistas y etnografía para el reconocimiento social y político del Pueblo Originario.RECONSTRUCCION DE MEMORIA HISTORICA 1. CONTEXTO GEOGRAFICO 2. MEMORIA, ABUSOS DE LA MEMORIA, MEMORIA HOSTORICA EN COLOMBIA. 3. CONCLUSIONES 4. RECOMENDACIONES BIBLIOGRAFÍAPregradoPsicólog

Diseño de unidad de atención integral para la rehabilitación y de reinserción social de víctimas del conflicto armado

El presente trabajo tiene como objetivo el diseño de una Unidad de rehabilitación Integral de victimas de mina antipersona y reinsertados a la vida civil. Partiendo desde la modelación de la plataforma estratégica, el estudio de mercado, técnico y financiero para establecer la viabilidad utilizando simuladores y conceptos de formulación de proyectos y financieros incluyendo el análisis de indicadores y así poder determinar la sostenibilidad del negocio, sus alcances y la determinación de riesgos al decidir invertir en una propuesta como esta. Se persigue además, la aplicación de conceptos pilares adquiridos a lo largo de la Especialización en Administración en Salud con Énfasis en Seguridad Social para afianzar el conocimiento y culminar el proceso de formación de los programas establecidos.The current work’ objective is the design of an Integral rehabilitation unit of antipersonnel mine victims and reinserted into civil life. Starting from the modeling of the strategic platform, the market analysis, technical and financial study, to establish its viability using simulators and concepts of project and financial formulation including the analysis of indicators and thus determine the sustainability of the business, its scope and the identification of risks when deciding to invest in a proposal like this. It also pursues the application of strategic concepts acquired throughout the Specialization in Health Management with Emphasis on Social Security at the Pontificia Universidad Javeriana, to strengthen the knowledge and conclusion of the formation process of the established programs.Especialista en Administración de SaludEspecializació

Haliotrematoides spp. (Monogenoidea: Dactylogyridae) parasitizing Lutjanus guttatus (Lutjanidae) in two localities of the Pacific coast of Mexico, and their phylogenetic position within the Ancyrocephalinae through sequences of the 28S rRNA

AbstractSpecimens of wild populations of the spotted rose snapper, Lutjanus guttatus (Steindacher) were studied for monogenean parasites in 2 localities along the Mexican Pacific coast (Mazatlán, Sinaloa and Chamela Bay, Jalisco). Five species of dactylogyrids were found on the gills of their hosts: Haliotrematoides guttati (García-Vargas, Fajer-Ávila, & Lamothe-Argumedo, 2008), H. plectridium Kristky and Mendoza-Franco in Kritsky, Tingbao, & Yuan, 2009, H. spinatus Kristky and Mendoza-Franco in Kritsky et al. (2009), Euryhaliotrema perezponcei García-Vargas, Fajer-Ávila & Lamothe-Argumedo, 2008 and E. mehen (Soler-Jiménez, García-Gasca, & Fajer-Avila, 2012). Freshly collected specimens provided an opportunity to study and compare specimens from different localities in further detail and few morphological characters were added to the description of each species. Additionally, a fragment of 856bp of the 28S ribosomal RNA (D1–D3) was obtained for all the sampled monogeneans, and a phylogenetic analysis along with all available sequences of dactylogyrids was conducted to establish the systematic position of the species within the Ancyrocephalinae. Our results suggest that species of Haliotrema might be included in Haliotrematoides genus. In addition, the genetic divergence data suggest that H. guttati and H. spinatus may represent a species complex; however, this asseveration needs additional data

Criterios de implementación ISO 14000:2015 Caso estudio sector construcción de edificios y Obras de Ingeniería.

El presente trabajo consiste en aplicar los requisitos de la norma ISO 14001:2015 para VICTOR ROMERO & CIA una empresa Colombiana de sociedad limitada,con sede principal en Bogotà D.C, dedicada principalmente a otras actividades especializadas para la construcción de edicios y obras de ingeniería civiles tradición, calidad y responsabilidad cuando se trata de conceptos y análisis técnicos sobre el comportamiento de los suelos y soluciones de cimentación. PILOTES MEGAPRES es una marca y sistema patentado por la empresa para la cimentación de estructuras nuevas o reforzamientos de cimentaciones con deformaciones,ampliaciones y otras necesidades.The present work consists in applying the requirements of the ISO 14001: 2015 standard for VICTOR ROMERO & CIA a Colombian company of limited company, with headquarters in Bogotà DC, mainly dedicated to other specialized activities for the construction of buildings and building works. Civil engineering tradition, quality and responsibility when it comes to technical concepts and analysis on the behavior of soils and foundation solutions. PILOTES MEGAPRES is a brand and system patented by the company for the foundation of new structures or reinforcement of foundations with deformations, extensions and other needs

Genetic markers in clinical subtypes of juvenile idiopathic arthritis

Poster presentatationInternational audienc

Cognitive Reserve as a Protective Factor of Mental Health in Middle-Aged Adults Affected by Chronic Pain

Chronic pain is associated with worse mental health and cognitive impairment, which can be a cause or a consequence of brain structure and function alterations, e.g., maladaptive plasticity, antinociceptive system dysregulation. Cognitive reserve reflects the effectiveness of the internal connections of the brain and it has been shown to be a protective factor in brain damage, slowing cognitive aging or reducing the risk of mental health disorders. The current study explored the impact of chronic pain on psychosocial factors, mental health, and cognition. Furthermore, we aimed to examine the role of cognitive reserve in the relationship between mental health and chronic pain clinical characteristics in middle-aged adults. The study group consisted of 477 volunteers from the Barcelona Brain Health Initiative who completed online surveys on pain, mental health, cognitive reserve, and psychosocial factors (sleep and quality of life). We described the differences in sociodemographic data, psychosocial factors, mental health, and self-perceived cognitive impairment, and neuropsychological assessment, between participants reporting pain compared with those without pain, as well as the main characteristics of the chronic pain group. Finally, to study the role of cognitive reserve in the modulation of the relationship between chronic pain and mental health, we compared variables between subgroups of participants with high/low pain intensity and cognitive reserve. The results showed that chronic pain was reported by 45.5% of middle-aged adults. Our results revealed that participants with chronic pain were older and had worse health status than people without pain. The presence of chronic pain affected working memory, mental health, and daily life activities. Moreover, cognitive reserve moderated the influence of pain intensity on mental health, resulting in less mental health affection in people suffering from high pain intensity with high cognitive reserve. In conclusion, the construct of the cognitive reserve could explain differential susceptibility between chronic pain and its mental health association and be a powerful tool in chronic pain assessment and treatment, principally due to its modifiable nature

BCLXL PROTAC degrader DT2216 targets secondary plasma cell leukemia addicted to BCLXL for survival

Secondary plasma cell leukemia (sPCL) is a rare form of aggressive plasma cell malignancy arising mostly at end-stage refractory multiple myeloma and consequently presenting limited therapeutic options. We analyzed 13 sPCL for their sensitivity to BH3 mimetics targeting either BCL2 (venetoclax) or BCLXL (A1155463) and showed that 3 sPCL were efficiently killed by venetoclax and 3 sPCL by A1155463. Accordingly, BH3 profiling of 2 sPCL sensitive to BCLXL inhibition confirmed their high BCLXL primed profile. While targeting BCLXL using BH3 mimetics induces platelets on-target drug toxicity, the recent development of DT2216, a clinical-stage BCLXL proteolysis targeting chimera PROTAC compound, provides an alternative strategy to target BCLXL. Indeed, DT2216 specifically degrades BCLXL via VHL E3 ligase, without inducing thrombocytopenia. We demonstrated in human myeloma cell lines and sPCL that sensitivity to DT2216 strongly correlated with the sensitivity to A1155463. Interestingly, we showed that low doses of DT2216 (nM range) were sufficient to specifically degrade BCLXL after 48 hours of treatment, consistent with VHL expression, in all cell lines but irrespectively to DT2216 sensitivity. In myeloma cells, DT2216 induced apoptotic cell death and triggered BAX and BAK activation. In conclusion, our study demonstrated that patients with sPCL addicted to BCLXL, a small but a very challenging group, could potentially receive therapeutic benefit from DT2216. Clinical trials of DT2216 in this subset of sPCL patients are warranted

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline

Background: Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be defined. Objectives: We aimed to determine whether regions associated with cross-sectional lung function were also associated with longitudinal decline and to seek novel variants which influence decline. Methods: We analysed genome-wide data from 4167 individuals from the Busselton Health Study cohort, who had undergone spirometry (12 695 observations across eight time points). A mixed model was fitted and weighted risk scores were calculated for the joint effect of 26 known regions on baseline and longitudinal changes in FEV1 and FEV1/FVC. Potential additional regions of interest were identified and followed up in two independent cohorts. Results: The 26 regions previously associated with cross-sectional lung function jointly showed a strong effect on baseline lung function (p=4.44×10−16 for FEV1/FVC) but no effect on longitudinal decline (p=0.160 for FEV1/FVC). This was replicated in an independent cohort. 39 additional regions of interest (48 variants) were identified; these associations were not replicated in two further cohorts. Conclusions: Previously identified genetic variants jointly have a strong effect on cross-sectional lung function in adults but little or no effect on the rate of decline of lung function. It is possible that they influence COPD risk through lung development. Although no genetic variants have yet been associated with lung function decline at stringent genome-wide significance, longitudinal change in lung function is heritable suggesting that there is scope for future discoveries

A high-resolution map of the Nile tilapia genome: a resource for studying cichlids and other percomorphs

Background: The Nile tilapia (Oreochromis niloticus) is the second most farmed fish species worldwide. It is also an important model for studies of fish physiology, particularly because of its broad tolerance to an array of environments. It is a good model to study evolutionary mechanisms in vertebrates, because of its close relationship to haplochromine cichlids, which have undergone rapid speciation in East Africa. The existing genomic resources for Nile tilapia include a genetic map, BAC end sequences and ESTs, but comparative genome analysis and maps of quantitative trait loci (QTL) are still limited. Results: We have constructed a high-resolution radiation hybrid (RH) panel for the Nile tilapia and genotyped 1358 markers consisting of 850 genes, 82 markers corresponding to BAC end sequences, 154 microsatellites and 272 single nucleotide polymorphisms (SNPs). From these, 1296 markers could be associated in 81 RH groups, while 62 were not linked. The total size of the RH map is 34,084 cR3500 and 937,310 kb. It covers 88% of the entire genome with an estimated inter-marker distance of 742 Kb. Mapping of microsatellites enabled integration to the genetic map. We have merged LG8 and LG24 into a single linkage group, and confirmed that LG16-LG21 are also merged. The orientation and association of RH groups to each chromosome and LG was confirmed by chromosomal in situ hybridizations (FISH) of 55 BACs. Fifty RH groups were localized on the 22 chromosomes while 31 remained small orphan groups. Synteny relationships were determined between Nile tilapia, stickleback, medaka and pufferfish. Conclusion:The RH map and associated FISH map provide a valuable gene-ordered resource for gene mapping and QTL studies. All genetic linkage groups with their corresponding RH groups now have a corresponding chromosome which can be identified in the karyotype. Placement of conserved segments indicated that multiple inter-chromosomal rearrangements have occurred between Nile tilapia and the other model fishes. These maps represent a valuable resource for organizing the forthcoming genome sequence of Nile tilapia, and provide a foundation for evolutionary studies of East African cichlid fishes.Additional co-authors: Thomas D Kocher, Catherine Ozouf-Costaz, Jean Francois Baroiller and Francis Galiber